DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Phlpp

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	159/879 - (18%)
Similarity:	262/879 - (29%)	Gaps:	383/879 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 QFPAVLSS-----------PAAALAFAIVTTFSLGTIAAITGDELAPLPMY-------------- 168
            |||...||           |:....|..||...|.|: .::.::|:.||.|
  Fly   199 QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETL-NVSCNKLSTLPRYEQNNHAALVNLSLA 262

  Fly   169 ------ALFLCIHSMLPISWPVSVVLALFMTAIHIVY-RIGTSPDYA----PNLPML-------- 214
                  ::|..:|:            |..:..:|:.| |||..|...    |.|.:|
  Fly   263 GNHLNDSIFEPLHN------------AAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQ 315

  Fly   215 --------FGEI--------VMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQ 263
                    .|::        ::|.:..::.|....:.|.:||..         .||.
  Fly   316 QLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHL---------DRVN-------- 363

  Fly   264 EQLLLSVIPA----YIAAEVKRSIMLKMAD----ACQ------------RAGGQASTSATRFHEL 308
               ||:::|:    |:  ::..::.|::.:    .||            ....:|:...|:..::
  Fly   364 ---LLALVPSRNLKYL--DLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQV 423

  Fly   309 HVQRHTNV-----TILFADIVNFTPLSS--------SLTASDLVKTLNDLFGRFDQI------AQ 354
            ..||:.|.     |:.||:    ||.|.        .|.|::...:...|:|.|:.:      ||
  Fly   424 SAQRNQNKTSGPWTMGFAE----TPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQ 484

  Fly   355 ENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMI--DAIRHVREATGINVDMRIGIHTGN 417
            |...|              :|....|.         ||:  .|:|...:.|
  Fly   485 EMSHL--------------VPDLMKQE---------QMVKDSAVRDYMKFT-------------- 512

  Fly   418 VLCGVLGLRKWQFDVWSDDVTLANHMESGGV--AGRVHITK-----QTLDFLGDKFEVEQGEGGN 475
                                .||...:.|.|  |...|:|:     :.......::.:.....|.
  Fly   513 --------------------LLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGG 557

  Fly   476 RDAYLADHKVESYL----IVPPKPAYTYSVPRVVECIEQNDPS-------------PTTEETKEI 523
            .||||.....:..|    ::.....::...|.|:|.|..||..             ......:||
  Fly   558 LDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREI 622

  Fly   524 KETDQS----------------------------HEATDVADVL--LPVTVAPPPAIVDEKMSPT 558
            ::.:.|                            |..|||..::  |..:|...|..|...:|..
  Fly   623 RKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSG 687

  Fly   559 SI------NSQEAPLH-----APLASAASMS--------------------IKELSEEE--DEAD 590
            |:      :...|..|     .|||..:|.|                    .:.|.||:  :..|
  Fly   688 SVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLD 752

  Fly   591 EATAVTEPLMHRDQD-------GKN-----DKEPKANGGHRGSGDSAASESVAKS--------AA 635
            |..:|:|.::..:|.       .:|     |||.           :..|:|..|.        ||
  Fly   753 ETESVSESVLSEEQFKCWEYMLEQNTQLLFDKEL-----------NTISKSFTKQRTVPNAIMAA 806

  Fly   636 LSLP-ADDL---LSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPE-RSRR 695
            ..|| .:|.   |..:.:...||.|..|.    |..:  |.:.|.|....    |.:||. ....
  Fly   807 TVLPERNDFTSNLMRTVTNKFISTSTPQL----PQPI--TTSVPLGSYHQ----VKQAPPGHFGS 861

  Fly   696 KLSVQGLMSFADR---------------RRSSG---------------------AFIEGRKLSI- 723
            .||.|...|:...               :||:|                     |..:.|:.:|
  Fly   862 ALSFQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQERERNIL 926

  Fly   724 ----HSGESFRSHAGHVTRNRPSSKMTKYVECWG 753
                |..:.|..|         .|:|.||   ||
  Fly   927 DEEEHDDDDFNEH---------ESRMRKY---WG 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	40/223 (18%)
		CYCc	259..467	CDD:214485	41/255 (16%)
		Guanylate_cyc	311..469	CDD:278633	32/185 (17%)
		BASP1	510..667	CDD:283191	48/256 (19%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380	5/9 (56%)
		LRR_8	205..266	CDD:290566	12/61 (20%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	6/23 (26%)
		LRR_RI	<256..410	CDD:238064	27/187 (14%)
		leucine-rich repeat	256..276	CDD:275380	1/19 (5%)
		LRR_8	279..359	CDD:290566	15/79 (19%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	5/43 (12%)
		leucine-rich repeat	349..372	CDD:275380	8/42 (19%)
		PP2Cc	461..655	CDD:294085	36/250 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900