Protein Alignment Ac76E and Ac13E

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Alignment Length: 1620
• Identity: 412/1620 - (25%)
• Similarity: 650/1620 - (40%)
• Gaps: 453/1620 - (27%)

  Fly    47 SASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIG---------- 101
            :|:.:.|..:.:....|:.:...::...|.|.|.:|... ||.||:.|:..::.|
  Fly    64 AAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYI-LLCSLMWCLYFVVDGGSEDFWRPIS 127

  Fly   102 -------------------IVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVT 147
                               .:|.:|...|. .|.|.|:.|                |:|||
  Fly   128 SSFSMLSLVTIMALCFTHWDLYREHRTVTS-AVTALLLCG----------------ASLAF---- 171

  Fly   148 TFSLGTIAAITGDELAPLPMYA----LFLCIHSMLPI------SWPVSVVLALFMTAIHIVYRIG 202
                   ...||...:||..:|    :.|.|::.||:      |..:|..:|..|.: |:|  ||
  Fly   172 -------LTYTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVS-HMV--IG 226

  Fly   203 TSPDYA--------------------PNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTR 247
            .|..:.                    |:..:|...|:...|..:.|::..||:......|.....
  Fly   227 CSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVG 291

  Fly   248 TGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSA---------- 302
            ..:..|.:||.|::.:|:::.||:|.            |:||.....||.:...|
  Fly   292 QNLLVRRQLEMEKQLKEKMIHSVMPP------------KVADMLLNEGGPSGLDAGGLPPESHYM 344

  Fly   303 ---------TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358
                     :.|...|:....||:|||||||.||.:||:.||..||:.|||||.|||.:...:.|
  Fly   345 RPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGC 409

  Fly   359 LRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVL 423
            .:|..||||||||||.|..|..||..||.|||.||||:|.........|.||:|:|||.||||::
  Fly   410 EKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIV 474

  Fly   424 GLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEG--GNRDAYLADHKVE 486
            |.|:.:|||||:||:|||.|||.|...:|||:::|..||||.:.:|:||.  |:|..::...:.:
  Fly   475 GTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRD 539

  Fly   487 -----------------SYLIVPPKPAYTYSVPRV-VECIEQN--------------DPSPT--- 516
                             |.|::|.....:.|.... |..::.|              :|||.
  Fly   540 FTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604

  Fly   517 ----TEETKEIKETDQSHEATDVADVLLPVTVAPPPAIV---------DEKMSPTSINSQE-APL 567
                |..:.::::..||.:......::.|.....||.||         ..|..|.|::|.| .|:
  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669

  Fly   568 HAPLASAASMSIKE---------------LSEEEDEADEAT-AVTEPLMHRDQDGKNDKEPK--- 613
            ..||...|:....|               |...||..:.:: ..:....|.|::.:.::|.:
  Fly   670 SPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEE 734

  Fly   614 --------------------ANGG-----------------------------HRGSGDSAASES 629
                                .||.                             |..:..:|.:.|
  Fly   735 LHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHAATSTALASS 799

  Fly   630 VAKSAALSLPA-------------DDLLS----MSGSESGIS---NSGA-QAQSSNPASVTPTAA 673
            |.:|....:..             ||::.    :|.|.|.||   .||: ::|....::.....|
  Fly   800 VLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGA 864

  Fly   674 APAG-GAASNSLTVAEAPERSRRKL-----------------------------------SVQG- 701
            .||| ||...:.|...||...:..|                                   ||.|
  Fly   865 GPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGG 929

  Fly   702 ------------LMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGA 754
                        :...|..|:.||.....|:.||.. :.:..:...::::|.|...|      .:
  Fly   930 GIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQ-QIYALNQTAISQHRVSGYFT------SS 987

  Fly   755 DRPFANIAESKLVKNIGLASIAMIESNLLPPE----------------RK--------CFNFN-- 793
            ....:|:.|   |:.:||.........||.|.                ||        |...|
  Fly   988 TSSISNLGE---VQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNAR 1049

  Fly   794 -----FFGPPTELKPFTMWYRNTPREAMYR------------------AQPDTHFRFDLICAFVL 835
                 ...||  |:.|::::::...|..:|                  |.|..:...|:.....:
  Fly  1050 SQRSYLVKPP--LRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFVGIAV 1112

  Fly   836 FLSLAVVQLIV----IELNLALLGSLLASFVSL---ALFLYL---------SNMSVPDVHASTT- 883
            :|.::|...::    :..:..|..:|.:.|..:   ||||:.         ||:|......|||
  Fly  1113 YLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTS 1177

  Fly   884 ---ERNGPGQVVASSRYLRLAMFVVVNILISSCA--VFSVINYTVPDGVSKEPSSNQTIL--ESN 941
               ||:..|.......:            ..|||  :|..|:...|..:.........:|  .:|
  Fly  1178 EDLERDERGAAPGGRPH------------FESCADRIFEAISSWYPWHICLAVLMAMPVLLIIAN 1230

  Fly   942 FSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAV---IAQV 1003
            |..:    .||.::.:|..|...|....::.|  :...::.::|:  :|..:|.|..:   ::|:
  Fly  1231 FLLL----DLEQLEAFEYHYGFLIFVCIVHFC--NFTQLNCWVRN--VLAFLAALCFIGIAVSQL 1287

  Fly  1004 TVLGY--SDLFEMYNDANITHGLPLEIKGF--------LLLLVIILVLHTLDRQGEYVARTDFLW 1058
            .|..:  ||..:....:|...    |||.|        |.||:|::::..|:|:.|...|..|..
  Fly  1288 MVYSHNRSDQQQDQEASNFIQ----EIKWFQDYHVEIYLDLLLILVLVWFLNREFEIGYRLTFYG 1348

  Fly  1059 KAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFY 1123
            .|....::..|:.|:....:||.||:|.|||.|.    ::|..|.|::..:|::||||.|:.|.|
  Fly  1349 NAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHL----KNTAKYSENHHNIAIIFASIVNFNEMY 1409

  Fly  1124 DETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFA 1188
            ||:.:.  |.|.||:|||:|.|||:||.:|:|..:||||||.||:|.||||.|
  Fly  1410 DESYLG--GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGLDP------------ 1460

  Fly  1189 DEKRTEEHNVVILVEFAIALMSILDSINRESFQ-RFRLRIGLNHGPVIAGVIGAQKPQYDIWSNT 1252
            ..:.|.:.::..|:||:||:..::|:.|::..: ...||||:|.|.|.|||||..|..||||.:.
  Fly  1461 SHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDA 1525

  Fly  1253 VNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL 1312
            |||||||||.|:..|:|..::....| |..||.|.||..|||||.::..:...|..|..|
  Fly  1526 VNVASRMDSTGLPNRIQVGKDCLPFL-TNRYEFEPRGSVYVKGKDHMEVFLYTTRRDNPL 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	149/475 (31%)
		Guanylate_cyc	310..469	CDD:425528	86/158 (54%)
		Guanylate_cyc	1101..1305	CDD:425528	90/204 (44%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	99/227 (44%)
		PHA03307	836..>1015	CDD:223039	37/188 (20%)
		Guanylate_cyc	1388..1575	CDD:425528	90/201 (45%)