Protein Alignment Ac76E and Adcy1

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 1168
• Identity: 375/1168 - (32%)
• Similarity: 550/1168 - (47%)
• Gaps: 278/1168 - (23%)

  Fly   159 GDELAPLPMYALFLCI---HSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFG-EIV 219
            |..:|...::.|.|..   :::||:...:::...|.:.|.|::......|...|.|....| ..:
  Rat     2 GSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANAL 66

  Fly   220 MLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIM 284
            :....::.|::.||:::.:..:.....|..||.|::||.|.|:||:||:|::|..:|.|:|.. .
  Rat    67 LFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED-F 130

  Fly   285 LKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRF 349
            ||..:..             ||::::|||.||:|||||||.||.|:|..||.:|||.||:|||:|
  Rat   131 LKPPERI-------------FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKF 182

  Fly   350 DQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIH 414
            |::|.||.|.|||||||||||||||...:..||..||.|||.|||.|..|.|||.::::||:|:|
  Rat   183 DELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLH 247

  Fly   415 TGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAY 479
            ||.||||||||||||:||||:||||||.||:.|:.|:|||||.||..|...:|||.|.|..|:.:
  Rat   248 TGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTF 312

  Fly   480 LADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTV 544
            |..|.:|::.|||                                    ||.
  Rat   313 LRTHNIETFFIVP------------------------------------SHR------------- 328

  Fly   545 APPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKND 609
                    .|:.|..|.|...|       |..|..|.:          ..:...|||
  Rat   329 --------RKIFPGLILSDIKP-------AKRMKFKTV----------CYLLVQLMH-------- 360

  Fly   610 KEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAA 674
                                ..|.....:|
  Rat   361 --------------------CRKMFKAEIP----------------------------------- 370

  Fly   675 PAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRN 739
                 .||.:|..:..:|...:.:.:.|     |.||                ||.::..:.|
  Rat   371 -----FSNVMTCEDDDKRRALRTASEKL-----RNRS----------------SFSTNVVYTT-- 407

  Fly   740 RPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPF 804
             |.:::.:|:.                         .::|:.....|....||           |
  Rat   408 -PGTRVNRYIS-------------------------RLLEARQTELEMADLNF-----------F 435

  Fly   805 TMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS---FVSLAL 866
            |:.|::..||..|....|.:|...::.|.:|.....::.|:||..::|:|..|:.|   .|:..|
  Rat   436 TLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTL 500

  Fly   867 FLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEP 931
            :|:::.:..           .||.:...   :|.|:.|.:.:||.|.|...|:: .:|...|...
  Rat   501 YLHITRVQC-----------FPGCLTIQ---IRTALCVFIVVLIYSVAQGCVVS-CLPWAWSSHS 550

  Fly   932 SSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPV-----FLYCCAISLAAISAFLRSGFILK 991
            :|:..:|.:.....                .:|..|.     .|.||.:....::.|||...:.|
  Rat   551 NSSLVVLAAGGRRT----------------VLPALPCESAHHGLLCCLVGTLPLAIFLRVSSLPK 599

  Fly   992 LIAMLVAVIAQVTVL---GYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVAR 1053
            :|.:.....:.:.||   ||:.:     ......|...|....:||....|.||.  ||.:...|
  Rat   600 MILLSGLTTSYILVLELSGYTKV-----GGGALSGRSYEPIMAILLFSCTLALHA--RQVDVRLR 657

  Fly  1054 TDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIP 1117
            .|:||.|:.:.|::::|.::..||.:|.|:||||||.|||... |:.:||::|||.|.|||||||
  Rat   658 LDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIP 722

  Fly  1118 NYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGA 1182
            |:.:||.|.|.|..|:||||||||||.|||:|:.|..:..:||||||.||||.|.||.|    .|
  Rat   723 NFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAP----TA 783

  Fly  1183 TSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYD 1247
            .:|:    |::...::..|.:|||.:..:||.||.:|:..|.||:|:|.|||:||||||::||||
  Rat   784 GTRA----KKSISSHLSTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYD 844

  Fly  1248 IWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            ||.|||||||||||.||.||:|.||...::|....|:..|||...|||||.::|||::...||
  Rat   845 IWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDG 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	35/133 (26%)
		CYCc	259..467	CDD:214485	117/207 (57%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	15/156 (10%)
		CYCc	1079..1283	CDD:214485	112/204 (55%)
		Guanylate_cyc	1101..1305	CDD:278633	112/203 (55%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:292831	34/146 (23%)
		CYCc	105..300	CDD:214485	117/208 (56%)
		Guanylate_cyc	141..323	CDD:278633	111/181 (61%)
		CYCc	673..884	CDD:214485	116/218 (53%)
		Guanylate_cyc	706..903	CDD:278633	112/204 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810