DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	383	Identity:	83/383 - (21%)
Similarity:	159/383 - (41%)	Gaps:	112/383 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 VYRIGTSPDYAPNLPMLF--------GEIVMLAS--------------------ASVSGLYYRIM 234
            ::|:..|....|..|.||        .|:.:|..                    |.:.||::...
Human   692 IFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQK 756

  Fly   235 SDA----------AHNRTVDGTRTGIEQRVKL-ECEREQQEQLLLSVIPAYIAAEVKRSIMLKMA 288
            :::          .::|.::..   :|:|.:| :.||::.::|...::|..:...:|....::
Human   757 NESYMDTLIRRLQLYSRNLEHL---VEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVE-- 816

  Fly   289 DACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIA 353
                             .||:.:    |||.|:|||.||.:....|..::|..|||::..||.|.
Human   817 -----------------PELYEE----VTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIV 860

  Fly   354 QENQCLRIKILGDCYYCVSGLP-ISRPQHATNCVNMGLQMID-----AIRHVREATGINVDMRIG 412
            ..:...:::.:||.|...|||| .:..:||.:...|.|:::.     .:.|:   .|:.:.:|||
Human   861 DHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHL---PGLPIWIRIG 922

  Fly   413 IHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTL--------DFLGDKFEVE 469
            :|:|....||:|::..::.::.|.|..|:.|||.|:..|:|::..|:        .||   :||.
Human   923 VHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFL---YEVR 984

  Fly   470 -----QGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKE 522
                 :|.|.....:|...|.:.:                      |.|:|.|.|.::
Human   985 GETYLKGRGNETTYWLTGMKDQKF----------------------NLPTPPTVENQQ 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	20/129 (16%)
		CYCc	259..467	CDD:214485	57/221 (26%)
		Guanylate_cyc	311..469	CDD:278633	51/171 (30%)
		BASP1	510..667	CDD:283191	5/13 (38%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946	9/57 (16%)
		Pkinase_Tyr	502..745	CDD:285015	8/52 (15%)
		CYCc	788..979	CDD:214485	55/216 (25%)
		Guanylate_cyc	815..1002	CDD:278633	57/215 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810