DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	377	Identity:	82/377 - (21%)
Similarity:	139/377 - (36%)	Gaps:	139/377 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 TRTGIEQRVK--------LECEREQQ------------------EQLLLSVIPAYIAAEV--KRS 282
            |.||...|::        :.||::.:                  .:||.||:|..:|.|:  ||.
Human   390 TDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRP 454

  Fly   283 IMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASD----LVKTLN 343
            :..|                         |:.||||||:.||.|....|...:.:    :|..||
Human   455 VPAK-------------------------RYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLN 494

  Fly   344 DLFGRFDQIAQENQ---CLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGI 405
            ||:.|||.:....:   ..:::.:||.|..|||||.....||.:..::.|.|::....| :..|.
Human   495 DLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGE 558

  Fly   406 NVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQ 470
            :|.:.||||||.|:.||:|.|..::.::.:.|.|.:..|:.|..|::::::
Human   559 SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSE-------------- 609

  Fly   471 GEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDV 535
                                      |||   |.:...|.:||              |.|.
Human   610 --------------------------YTY---RCLMSPENSDP--------------QFHL---- 627

  Fly   536 ADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEED 587
                             |...|.|:..::.|:.....|..:...:|..:::|
Human   628 -----------------EHRGPVSMKGKKEPMQVWFLSRKNTGTEETKQDDD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	16/70 (23%)
		CYCc	259..467	CDD:214485	61/234 (26%)
		Guanylate_cyc	311..469	CDD:278633	50/164 (30%)
		BASP1	510..667	CDD:283191	11/78 (14%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	12/58 (21%)
		Guanylate_cyc	455..648	CDD:306677	64/296 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810