DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	276	Identity:	78/276 - (28%)
Similarity:	127/276 - (46%)	Gaps:	55/276 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 IVMLASASVS--------GLYYRIMSD-AAHNRTVD--------GTRTGIEQRV-KLECEREQQE 264
            |:.|.|..|.        |||   :|| ..||...|        ..:.|:::|: ||:...||..
Human   379 ILFLGSPCVDRLEDFTGRGLY---LSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAH 440

  Fly   265 Q-----------LLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
            |           ||.|:.|..:|.::.:              ||.         :..::.:|||:
Human   441 QALEEEKKKTVDLLCSIFPCEVAQQLWQ--------------GQV---------VQAKKFSNVTM 482

  Fly   319 LFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHAT 383
            ||:|||.||.:.|..:...::..||.|:.||||...|....:::.:||.|....||......||.
Human   483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

  Fly   384 NCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGV 448
            ....|.|:|::....|....|..:.||||:|:|:|..||:|::..::.::.::|||||..||..|
Human   548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSV 612

  Fly   449 AGRVHITKQTLDFLGD 464
            ..:::::..|...|.|
Human   613 PRKINVSPTTYRLLKD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	24/99 (24%)
		CYCc	259..467	CDD:214485	62/217 (29%)
		Guanylate_cyc	311..469	CDD:278633	52/154 (34%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	24/89 (27%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	52/157 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810