Protein Alignment Ac76E and GUCY1A2

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001243353.1
• Gene: GUCY1A2 / 2977
• HGNCID: 4684
• Length: 763
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 95/431 - (22%)
• Similarity: 161/431 - (37%)
• Gaps: 164/431 - (38%)

  Fly   218 IVMLASASVS--------GLYYRIMSD-AAHNRTVD--------GTRTGIEQRV----------- 254
            |:.|.|..|.        ||:   :|| ..|:.|.|        ..:.|:::|:
Human   419 ILFLGSPCVDKLDELMGRGLH---LSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH 480

  Fly   255 -KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
             .||.|:::...||.|:.|..:|.::.:              ||         ::..::..:||:
Human   481 QALEEEKKKTVDLLYSIFPGDVAQQLWQ--------------GQ---------QVQARKFDDVTM 522

  Fly   319 LFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC-----LRIKILGDCYYCVSGLPISR 378
            ||:|||.||.:.:..|...::..||:|:.|||     :||     .:::.:||.|...:||....
Human   523 LFSDIVGFTAICAQCTPMQVISMLNELYTRFD-----HQCGFLDIYKVETIGDAYCVAAGLHRKS 582

  Fly   379 PQHATNCVNMGLQMIDAIRHVREATGINVD-------------------------------MRIG 412
            ..||.....|.|:|::....|....|..:.                               ||||
Human   583 LCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIG 647

  Fly   413 IHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRD 477
            ||:|:||.||:|:|..::.::.::||||:..|||....|::::..|
Human   648 IHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT------------------- 693

  Fly   478 AYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPV 542
                      |.::..:.::|: :||..|.:..|.|       |||..          ....|.|
Human   694 ----------YQLLKREESFTF-IPRSREELPDNFP-------KEIPG----------ICYFLEV 730

  Fly   543 TVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELS 583
            ...|.|                     |..|.:|..||::|
Human   731 RTGPKP---------------------PKPSLSSSRIKKVS 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	21/99 (21%)
		CYCc	259..467	CDD:214485	60/243 (25%)
		Guanylate_cyc	311..469	CDD:278633	52/193 (27%)
		BASP1	510..667	CDD:283191	15/74 (20%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002
		HNOBA	316..503	CDD:285003	20/86 (23%)
		CYCc	485..705	CDD:214485	61/276 (22%)
		Guanylate_cyc	514..729	CDD:278633	62/266 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810