DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy10

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	1188	Identity:	212/1188 - (17%)
Similarity:	379/1188 - (31%)	Gaps:	386/1188 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 VKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
            ::|.|..|...:|.|| :..|:     ..|:||..|..|..|             ::.....|||
Mouse   249 LRLACMLESDPELELS-LQKYV-----MEIILKQIDDKQLRG-------------YLSELRPVTI 294

  Fly   319 LFADIV-----NFTPLSSSLTAS--DLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI 376
            :|.:::     ....:.|::.|:  .:...|....|:.:::...::       |..:.||.|.|.
Mouse   295 VFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFRGQINKVFMFDK-------GCSFLCVFGFPG 352

  Fly   377 SR-PQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLG-LRKWQFDVWSDDVTL 439
            .: |...|:.:...:.:.|....|.:...::    ||:.:|.|.||::| ..:.::.|....|.:
Mouse   353 EKAPDEITHALESAVDIFDFCSQVHKIRTVS----IGVASGIVFCGIVGHTVRHEYTVIGQKVNI 413

  Fly   440 ANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYL--IVPPKPAYTYSVP 502
            |..|.. ...|.|.....|.|            |.|..||......:..:  :..|.|.|
Mouse   414 AARMMM-YYPGIVSCDSVTYD------------GSNLPAYFFKELPKKVMKGVADPGPVY----- 460

  Fly   503 RVVECIEQNDP---------------SPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVD 552
               :|:..|:.               .|.....:||     .:..:.:.|.|:
Mouse   461 ---QCLGLNEKVMFGMAYLICNRYEGYPLLGRVREI-----DYFMSTMKDFLM------------ 505

  Fly   553 EKMSPTSINSQEAPLHAPL----ASAASMSIKEL-SEEEDEADEATAVTEPLMHRD--------- 603
                   .|.....::..|    .|...|.|:.| |:.|:....|.|:|:...|::
Mouse   506 -------TNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMA 563

  Fly   604 -----QDGKNDKEPKANGGHR----------------------GSGDSAASESVAKSAALSLPAD 641
                 ...|:.||.:.|..:|                      .|.:.:....:.|...|.....
Mouse   564 NVLGLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFM 628

  Fly   642 DLLSMSGSESGISNSGAQAQ-----------------------SSNPASVTPTAAAPAGGAASNS 683
            .:|:.:..|..|.....:||                       |..|.|..|.|||.|.....|:
Mouse   629 KILAQTVREERIIFIIDEAQFVDGTSWAFIEKLIRSMPIFIVMSLAPFSEVPCAAANAIMKNRNT 693

  Fly   684 LTV---AEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKM 745
            ..:   ...|:..|.|:.|...:|...|...| ..:||                       |..:
Mouse   694 TYITLGTMQPQEIRDKVCVDLSVSSIPRELDS-YLVEG-----------------------SCGI 734

  Fly   746 TKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRN 810
            ..|.|              :|:||:....:.:.:.                ..||.|....|  |
Mouse   735 PYYCE--------------ELLKNLDHHRVLLFQQ----------------AETEQKTNVTW--N 767

  Fly   811 TPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSV 875
            ...:...|...|..          ||.|::..|..|         ..|.|.|.      |:|:|.
Mouse   768 NMFKHSVRPTDDMQ----------LFTSISEGQKEV---------CYLVSGVR------LNNLSP 807

  Fly   876 PDVHASTTERNGPGQVVASSRYLRLAMFVVVNI---LISSCAVFSVINYTVPDGVSKEPSSNQ-- 935
            |                ||.:.:.|.....:::   ::..||....:.:|........|..|.
Mouse   808 P----------------ASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKM 856

  Fly   936 ------TILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIA 994
                  |::|||..:.|.:|  :|:|| .:...:|...|.....|:.       |:.|
Mouse   857 MIKALATLVESNVFNCFRSS--KDLQL-ALKQNVPTFEVHYRSLALK-------LKEG------- 904

  Fly   995 MLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWK 1059
                       |.|.:..|:           .|::|.::...|:.....:.::..|.     ||
Mouse   905 -----------LTYGEEEEL-----------REMEGEVVECRILRFCRPIMQKTAYE-----LW- 941

  Fly  1060 AKLKVEQEEV----------ETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFA 1114
              || :|::|          |:....|.....:.:|.|   ||:...|...|   ....|..|..
Mouse   942 --LK-DQKKVLHLKCARFLEESAHRCNHCRNVDFIPYH---HFIVDIRLNTL---DMDTVKRMVT 997

  Fly  1115 S----IPNYKEFYDETDVNK-----QGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMC 1170
            |    |...:..:.::::.:     :.|....:..:|:..||.::||.|.|..:.|.  ..:..|
Mouse   998 SQGFKIDEEEAIFSKSELPRKYKFPENLSITEIREKILHFFDNVILKMKSSPNDIIP--LESCQC 1060

  Fly  1171 ASGLR----PGKEDGATSRSFADEKRTEEHNVVI--LVEFAIALMSILDSINRESFQRFRLRIGL 1229
            ...|:    |      .::.|.   ..||:|..:  .:|.|.|.:.:.|:.|...:        |
Mouse  1061 KELLQIVILP------LAQHFV---ALEENNKALYYFLELASAYLILGDNYNAYMY--------L 1108

  Fly  1230 NHGPVIAGVIGAQKPQYDIWSNTVNVAS----RMDSCGVMGRLQTTE---NTAKILMTAGYECEC 1287
            ..|..:...:..:    |.||.|...|:    :.:.|..||::...:   ..|..|:...:.|..
Mouse  1109 GEGERLLKSLTNE----DSWSQTFEYATFYSLKAEVCFNMGQMVLAKKMLRKALKLLNRMFPCNL 1169

  Fly  1288 RGLTY-VKGKGNLVTYFV 1304
            ..||: :..:.|.:::|:
Mouse  1170 LTLTFQMHVEKNRLSHFM 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	10/34 (29%)
		CYCc	259..467	CDD:214485	43/216 (20%)
		Guanylate_cyc	311..469	CDD:278633	32/166 (19%)
		BASP1	510..667	CDD:283191	33/235 (14%)
		CYCc	1079..1283	CDD:214485	43/225 (19%)
		Guanylate_cyc	1101..1305	CDD:278633	43/227 (19%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	39/200 (20%)
		COG3899	485..>959	CDD:226415	108/642 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900