DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	88/390 - (22%)
Similarity:	164/390 - (42%)	Gaps:	112/390 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 VYRIGTSPDYAPNLPMLF--------GEIVMLAS--------------------ASVSGLYYRIM 234
            ::|:..|....|..|.||        .|:.:|..                    |.:.||::...
  Rat   691 IFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQK 755

  Fly   235 SDA----------AHNRTVDGTRTGIEQRVKL-ECEREQQEQLLLSVIPAYIAAEVKRSIMLKMA 288
            :::          .::|.::..   :|:|.:| :.||::.:.|...::|..:...:|...:::
  Rat   756 NESYMDTLIRRLQLYSRNLEHL---VEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVE-- 815

  Fly   289 DACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIA 353
                             .||:.:    |||.|:|||.||.:....|..::|..|||::..||||.
  Rat   816 -----------------PELYEE----VTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIV 859

  Fly   354 QENQCLRIKILGDCYYCVSGLPI-SRPQHATNCVNMGLQMID-----AIRHVREATGINVDMRIG 412
            ..:...:::.:||.|...||||: :..:||.:...|.|.::.     .:.|:   .|:.|.:|||
  Rat   860 DHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHL---PGLPVWIRIG 921

  Fly   413 IHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTL--------DFLGDKFEVE 469
            :|:|....||:|::..::.::.|.|..|:.|||.|:..|:|::..|:        .||   :||.
  Rat   922 VHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFL---YEVR 983

  Fly   470 -----QGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQS 529
                 :|.|.....:|...|.:.|                      |.|:|.|.|.::..:|:.|
  Rat   984 GETYLKGRGTETTYWLTGMKDQEY----------------------NLPTPPTVENQQRLQTEFS 1026

Fly 530 529
Rat 1027 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	20/129 (16%)
		CYCc	259..467	CDD:214485	59/221 (27%)
		Guanylate_cyc	311..469	CDD:278633	53/171 (31%)
		BASP1	510..667	CDD:283191	7/20 (35%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141
		PKc_like	479..749	CDD:304357	9/57 (16%)
		STYKc	501..744	CDD:214568	8/52 (15%)
		CYCc	787..978	CDD:214485	57/216 (26%)
		Guanylate_cyc	814..1001	CDD:278633	59/215 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810