DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Npr3

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_006232107.1	Gene:	Npr3 / 25339	RGDID:	3196	Length:	652	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	55/271 - (20%)
Similarity:	89/271 - (32%)	Gaps:	63/271 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 IAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTG 416
            ||:|:..|....|....:|..|.|            .|.|.....:...|...:....|.....|
  Rat    57 IAEESSSLSFGALLKGVFCFLGAP------------KGAQGQRKEKSREERGRVGGGQRASRWPG 109

  Fly   417 NVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGG---NRDA 478
            ..|.| ..:|......:|..|.||..:.:||.:...          ||     .|.|.   .|:|
  Rat   110 RALAG-NRMRSLLLFTFSACVLLARALLAGGASSGG----------GD-----TGPGNRRREREA 158

  Fly   479 YLADHKVESYLIVPPKPAYTYSVPRV-------VECIEQNDPS-----PTTEETKEIKETDQSHE 531
             ||..|:|..:::|...:|.:|:.||       :..:|.|...     |.|......:::|..:.
  Rat   159 -LAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNR 222

  Fly   532 AT-DVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEED-EADEATA 594
            |. .:.|.:.....|.|..|:                 .|:...|:..:..|:...| ....|.|
  Rat   223 ALFSLVDRVAAARGAKPDLIL-----------------GPVCEYAAAPVARLASHWDLPMLSAGA 270

  Fly   595 VTEPLMHRDQD 605
            :.....|:|.:
  Rat   271 LAAGFQHKDTE 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485	24/114 (21%)
		Guanylate_cyc	311..469	CDD:278633	24/116 (21%)
		BASP1	510..667	CDD:283191	17/103 (17%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Npr3	XP_006232107.1	PBP1_NPR_C_like	165..556	CDD:107381	24/134 (18%)
		ANF_receptor	182..535	CDD:279440	20/117 (17%)
		TM_EphA1	587..618	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900