Protein Alignment Ac76E and Adcy6

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1357
• Identity: 416/1357 - (30%)
• Similarity: 609/1357 - (44%)
• Gaps: 366/1357 - (26%)

  Fly    26 DGNATQP----KAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKS----- 81
            |...|.|    :....::.|...:....||.:.:.:...:|:   |..||.||..::.:|
  Rat   106 DTEVTTPMGTAEVAPDTSPRSGPSCWHRLAQVFQSKQFRSAK---LERLYQRYFFQMNQSSLTLL 167

  Fly    82 -----LFRSGLLT-------------SLLAC--VVSIIIGIVYGQH-LVQTMLLVLAALISGSIL 125
                 |..:.|||             :||.|  |:.:::.:|..:| ..|..:.|::.::.| ||
  Rat   168 MAVLVLLMAVLLTFHAAPALPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLG-IL 231

  Fly   126 TALQFPAVLS----SPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSV 186
            .|:|....|:    ||:|.|.                      .|::.::: .:::|||....:|
  Rat   232 AAVQVGGALAANPRSPSAGLW----------------------CPVFFVYI-TYTLLPIRMRAAV 273

  Fly   187 VLALFMTAIHIV--YRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTG 249
            :..|.::.:|::  :.:.....:.  ...|...:|:....:..|:.....::.:..:....||..
  Rat   274 LSGLGLSTLHLILAWHLNNGDPFL--WKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGY 336

  Fly   250 IEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHT 314
            |:.|:.|:.|..|||:|||||:|.::|.|:|..|..|..|             ..||::::|:|.
  Rat   337 IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKED-------------MMFHKIYIQKHD 388

  Fly   315 NVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRP 379
            ||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||||||||||||||||||.:|.
  Rat   389 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARA 453

  Fly   380 QHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 444
            .||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:|||||||||
  Rat   454 DHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHME 518

  Fly   445 SGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIE 509
            :||.|||:|||:.||.:|...:|||.|.||.|:|||.:..:|::||:
  Rat   519 AGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLIL------------------ 565

  Fly   510 QNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEA--PLHAPLA 572
                 ..:::.||.|.            :|:             |:..|..||.|.  |...|
  Rat   566 -----GASQKRKEEKA------------MLV-------------KLQRTRANSMEGLMPRWVP-- 598

  Fly   573 SAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALS 637
                                                              |.|.|.:....|...
  Rat   599 --------------------------------------------------DRAFSRTKDSKAFRQ 613

  Fly   638 LPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGL 702
            :..||        |...|.||| .:.||..                    |..|
  Rat   614 MGIDD--------SSKENRGAQ-DALNPED--------------------EVDE----------- 638

  Fly   703 MSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLV 767
                        |: ||.:...|.:..|.  .||.|
  Rat   639 ------------FL-GRAIDARSIDQLRK--DHVRR----------------------------- 659

  Fly   768 KNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICA 832
                                                |.:.::....|..|..:.|..|...:.||
  Rat   660 ------------------------------------FLLTFQREDLEKKYSRKVDPRFGAYVACA 688

  Fly   833 FVLFLSLAVVQLIVIELNLALLGSLLASFVSLAL-FLYLSNMSVPDVHASTTERNGPGQVVASSR 896
            .::|..:..:|.:|...:..:||.....|:.|.: .|..:..|......:..:|.....|.:...
  Rat   689 LLVFCFICFIQFLVFPHSALILGIYAGIFLLLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVH 753

  Fly   897 YLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDV---QLWE 958
            ...:.:|.|:.:.||:.|.....::|        |.       ...::..:|.|..||   .|.:
  Rat   754 STAVGVFSVLLVFISAIANMFTCSHT--------PL-------RTCAARMLNLTPSDVTACHLRQ 803

  Fly   959 IDYAIPI-APV-------------FLYCCAISLAAISAFLRSGFILKLIAMLVA--VIAQVTVLG 1007
            ::|::.: ||:             |:....:||.|.|.||....|.||:...|.  :...:.:||
  Rat   804 LNYSLGLEAPLCEGTAPTCSFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLG 868

  Fly  1008 -YSDLFEMYNDANITHGLPLEIKGF------------------LLLLVIILVLHTLDRQGEYVAR 1053
             .:.:|:.|:.....|||....:.|                  ::|||..|.|:...:|.|..||
  Rat   869 PPATIFDNYDLLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTAR 933

  Fly  1054 TDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIP 1117
            .|||||.:...|:||:|.::..|:.||.||||..||.|||..| |:.|||::|..|||||||||.
  Rat   934 LDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 998

  Fly  1118 NYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGA 1182
            |:.|||.|.:.|.:|:||||||||||.|||:::.:.:|..:||||||.||||.||||.....| .
  Rat   999 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYD-Q 1062

  Fly  1183 TSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYD 1247
            ..||          ::..|.::|:.||..:..||..||..|:::||||.|||:||||||:|||||
  Rat  1063 VGRS----------HITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYD 1117

  Fly  1248 IWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFV 1304
            ||.|||||:|||||.||..|:|.|.:..::|...||:.||||:..|||||.:.|||:
  Rat  1118 IWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	167/429 (39%)
		Guanylate_cyc	310..469	CDD:425528	108/158 (68%)
		Guanylate_cyc	1101..1305	CDD:425528	109/204 (53%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	66/315 (21%)
		Guanylate_cyc	382..566	CDD:425528	120/206 (58%)
		Adcy_cons_dom	594..681	CDD:461877	29/258 (11%)
		Guanylate_cyc	982..1176	CDD:425528	109/204 (53%)