DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	152/669 - (22%)
Similarity:	260/669 - (38%)	Gaps:	193/669 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNHNAETAKTGNGTNATANLIVKA-----DGNATQPKAMTSSAARMNDALSASLADLSE----- 55
            :::.|.|..:||...:....::.||     ...|::|:....|.|. .:||..:|..:.|
  Rat   163 ILDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQAD-QEALQGTLLRMKERYLNI 226

  Fly    56 -----QENGTTAEDIHLNDLYTRYRQRLRKS-LFRSGLLTSLLACVVSIIIGI-------VYGQH 107
                 :::.:||               :|.| ||..|.|......|....:.:       .:..|
  Rat   227 PVCPGEKSHSTA---------------VRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFH 276

  Fly   108 LV-QTMLLVLAALISGSILTALQ--FPAVLSSP-AAALAFAIV---TTFSLGTIAAI-------- 157
            :| ...|.|..|.::      :|  .|.:|:.. |....|:|:   .||::.:|...
  Rat   277 IVFDEALRVKQAGVN------IQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLK 335

  Fly   158 TGDELAP-----LPMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGE 217
            |..|:.|     .||..|      ...:.|..|:...:||          .||           :
  Rat   336 TRKEMMPKARKSQPMLKL------RGQMIWMESLRCMIFM----------CSP-----------K 373

  Fly   218 IVMLASASVSGLYYRIMSDAAHNRTVDGTRTGI---EQR---VKLEC------------------ 258
            :..|.....|.::   :||.|.:   |.||..|   :||   ::|.|
  Rat   374 LRSLQELEESKMH---LSDIAPH---DTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAI 432

  Fly   259 EREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADI 323
            |:::.|.||.:::|.::|.::|        :..:.|.|:..|               .||||:|:
  Rat   433 EKKKTETLLYAMLPEHVANQLK--------EGRKVAAGEFET---------------CTILFSDV 474

  Fly   324 VNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNM 388
            |.||.:.::.....:|..||.::.:||::...:...:::.:||.|..|.|:|:....||....|.
  Rat   475 VTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANF 539

  Fly   389 GLQM-IDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRV 452
            .|.| |.|...:...||..:.:|:|||||.||.||:|.:..::.::.|.|..|:.|||.|:..:|
  Rat   540 ALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKV 604

  Fly   453 HITKQTLDFLGDK-FEV-------EQGEGGNRDAYLADHKVESYLIV-------------PPKPA 496
            |::......|.:| ||:       .:|:|          |:.:|.::             |..||
  Rat   605 HLSPTAHRALKNKGFEIVRRGEIEVKGKG----------KMTTYFLIQNLNATEDEIMGRPSAPA 659

  Fly   497 YTYSVPRVVECIEQND--PSPTTEETKEIKETDQSHEA--TDVADVLLPVTVAPPPAIVDEKMSP 557
            ....|     |...|.  .||...     :.||...:.  .|.||....||:|..|  |..:.|.
  Rat   660 DGKEV-----CTPGNQVRKSPAVP-----RNTDHQQQVYKGDPADASNEVTLAGSP--VAGRNST 712

  Fly   558 TSINSQEAPLHAPLASAAS 576
            .::|:|.:|.....:..||
  Rat   713 DAVNNQPSPDETKTSVVAS 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	53/273 (19%)
		CYCc	259..467	CDD:214485	60/209 (29%)
		Guanylate_cyc	311..469	CDD:278633	52/166 (31%)
		BASP1	510..667	CDD:283191	19/71 (27%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	152/669 (23%)
		HNOBA	267..453	CDD:285003	45/224 (20%)
		CYCc	432..622	CDD:214485	62/212 (29%)
		Guanylate_cyc	459..642	CDD:278633	59/207 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810