DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_036901.2	Gene:	Gucy1b1 / 25202	RGDID:	2769	Length:	619	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	94/408 - (23%)
Similarity:	154/408 - (37%)	Gaps:	145/408 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 IVMLASASV--------SGLYYRIMSD-AAHNRTVDGTRTGIEQRVK------------------ 255
            |:.|.|.||        .|||   :|| ..|:.|.|....|.:.|.:
  Rat   319 ILFLCSPSVMNLDDLTRRGLY---LSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTL 380

  Fly   256 --LECEREQQEQLLLSVIPAYIAAEV--KRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNV 316
              ||.|:::.:.||.||:|..:|.|:  ||.:..|                         |:.||
  Rat   381 RALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAK-------------------------RYDNV 420

  Fly   317 TILFADIVNFTPLSSSLTASD----LVKTLNDLFGRFDQIAQENQ---CLRIKILGDCYYCVSGL 374
            ||||:.||.|....|...:.:    :|..||||:.|||.:....:   ..:::.:||.|..||||
  Rat   421 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGL 485

  Fly   375 PISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
            |.....||.:..::.|.|::....| :..|.:|.:.||||||.|:.||:|.|..::.::.:.|.|
  Rat   486 PEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNL 549

  Fly   440 ANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRV 504
            .:..|:.|..|::::::                                        |||   |.
  Rat   550 TSRTETTGEKGKINVSE----------------------------------------YTY---RC 571

  Fly   505 VECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHA 569
            :...|.:||              |.|.                     |...|.|:..::.|:..
  Rat   572 LMSPENSDP--------------QFHL---------------------EHRGPVSMKGKKEPMQV 601

  Fly   570 PLASAASMSIKELSEEED 587
            ...|..:...:|.:::|:
  Rat   602 WFLSRKNTGTEETNQDEN 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	28/101 (28%)
		CYCc	259..467	CDD:214485	61/216 (28%)
		Guanylate_cyc	311..469	CDD:278633	50/164 (30%)
		BASP1	510..667	CDD:283191	11/78 (14%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	24/89 (27%)
		CYCc	385..584	CDD:214485	69/281 (25%)
		Guanylate_cyc	412..605	CDD:278633	64/296 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810