DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	908	Identity:	192/908 - (21%)
Similarity:	322/908 - (35%)	Gaps:	316/908 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   552 DEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDE------------ADEAT--AVTEPLMHR 602
            ::::||.|     |.||..|...| .:::|:.:.|.:            ||:.|  .:|.|:: .
  Rat   344 EDQVSPYS-----AYLHDALLLYA-QTVEEMMKAEKDFRDGRQLISTLRADQVTLQGITGPVL-L 401

  Fly   603 DQDGKNDKE------PKANGGHRGSGDSAASESVAKSAALSLP--------------ADDLLSMS 647
            |..||...:      .|:..|.|                 .||              .|||
  Rat   402 DAQGKRHMDYSVYALQKSGNGSR-----------------FLPFLHYDSFQKVIRPWRDDL---- 445

  Fly   648 GSESGISNSGAQ-----------AQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQG 701
             :.||...|..:           .::..|.....||:..|.......|.||.|       .::.|
  Rat   446 -NASGPHGSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVASA-------AAITG 502

  Fly   702 LMSFADRRRSSGAFIEGRKLSIHSGES-FRSHAGHVT---RNRPSSKMTKYVECWGADRPFANI- 761
            ||.:    |..|      |:..|.|:: ::.|...:|   :::||.:.|....|..::.....|
  Rat   503 LMLW----RLRG------KVQNHPGDTWWQIHYDSITLLPQHKPSHRGTPMSRCNVSNASTVKIS 557

  Fly   762 ------------------------------------AESKLVKNIGLASIAMI----ESNLLPPE 786
                                                ||:::.|...|..:.::    ..|::|
  Rat   558 ADCGSFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAEARIKKPTVLREVWLMCELKHENIVP-- 620

  Fly   787 RKCFNFNFFG----PPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVI 847
                   |||    ||..........:.:.::.:..:..:..:.|.|
  Rat   621 -------FFGVCTEPPNICIVTQCCKKGSLKDVLRNSDHEMDWIFKL------------------ 660

  Fly   848 ELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNG---PGQ-VVASSRYLRLAMFVVVNI 908
                    |.:...|:..|||          |.|....:|   |.. :|.|...|:||.|.:...
  Rat   661 --------SFVYDIVNGMLFL----------HGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEF 707

  Fly   909 LI-SSCAVF-------SVINYTVPD----------GVSKEPSSNQTILESNFSSVFVNSTLEDVQ 955
            .. |:|.::       |.:.:|.|:          |..:....:..||..:......:...||::
  Rat   708 KHGSTCRIYNQEATDHSELYWTAPELLRLRELPWSGTPQGDVYSFAILLRDLIHQQAHGPFEDLE 772

  Fly   956 ---------LWEIDYAIPIAPVFL-------------YCCAIS------LAAISAFLRSGFILKL 992
                     :.:....:|:.|..|             .|.|.|      ..:|...||.......
  Rat   773 AAPEEIISCIKDSRAPVPLRPSLLEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGR 837

  Fly   993 IAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYV-ARTDF 1056
            :::|.:::.::         |||    .:|   ||                     |.| .||..
  Rat   838 VSILDSMMGKL---------EMY----ASH---LE---------------------EVVEERTCQ 865

  Fly  1057 LWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKE 1121
            |...|.|||:            ||..:||:.|....: ..:|.|..|  :..|.:.|:.|..:.:
  Rat   866 LVAEKRKVEK------------LLSTMLPSFVGEQLI-AGKSVEPEH--FESVTIFFSDIVGFTK 915

  Fly  1122 FYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGL--RPGKEDGATS 1184
            ....:    ..|:.::|||::...||..:   :...:.|::||...||.||||  |.|.:
  Rat   916 LCSLS----SPLQVVKLLNDLYSLFDHTI---QTHDVYKVETIGDAYMVASGLPIRNGAQ----- 968

  Fly  1185 RSFADEKRTEE-HNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDI 1248
              .|||..|.. |.:.:...|.|..|         ..:|.:|||||:.|||:|||:|...|:|.:
  Rat   969 --HADEIATMSLHLLSVTTNFQIGHM---------PEERLKLRIGLHTGPVVAGVVGITMPRYCL 1022

  Fly  1249 WSNTVNVASRMDSCGVMGRLQTTENTAKILMTA-GYECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            :.:|||:||||:|..:..|:..:::||:.|:.| ||..:.||...|||||...|::: |..||
  Rat  1023 FGDTVNMASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWL-TGKDG 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191	30/159 (19%)
		CYCc	1079..1283	CDD:214485	64/207 (31%)
		Guanylate_cyc	1101..1305	CDD:278633	67/207 (32%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	23/118 (19%)
		ANF_receptor	66..417	CDD:279440	18/79 (23%)
		PK_GC	558..832	CDD:270894	47/318 (15%)
		CYCc	868..1058	CDD:214485	68/227 (30%)
		Guanylate_cyc	895..1081	CDD:278633	68/211 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810