DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	971	Identity:	203/971 - (20%)
Similarity:	313/971 - (32%)	Gaps:	304/971 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLR 79
            |..|.|:    :||    |.:|....|.|......|:.|      .:.|.:|..      |.:||
Mouse   461 TVITENM----EGN----KHITHMDLRDNQLTDLDLSSL------CSLEQLHCE------RNQLR 505

  Fly    80 KSLFRSGLLTSLLAC-----------VVSIIIGIVYGQHLVQTM---------LLVLAALISGSI 124
            :.......|.:|.|.           |.|::..:...|:|::.:         |.:|.  ||.::
Mouse   506 ELTLSGFSLRTLYASWNRLTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLEILD--ISHNL 568

  Fly   125 LTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVLA 189
            ||.:.. .:|||  .:|...:|....:..:.|:.  |..||.:..:.....|.||.:
Mouse   569 LTEVPM-RILSS--LSLRKLMVGHNHIHVLPALV--EHIPLEVLDIQHNTLSRLPDT-------- 620

  Fly   190 LFMTAIHIVYRIGTSPDYAPNLP-MLFGEIVMLASASVSGLYY---RIMSDAA--------HNRT 242
            ||..|:::.| :..|.:...:|| ...||    .|.||..|.|   .:::|..        |.|.
Mouse   621 LFSKALNLRY-LNASANSLESLPSACAGE----ESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRV 680

  Fly   243 VDGTRTGIE--QRVKLECEREQQEQLLLS-----VIPAYIAAEVKRSIMLKMADACQRAGGQAST 300
            :......::  ...||. :.||.|:|.||     .||..||
Mouse   681 LHLANNQLQTFPASKLN-KLEQLEELNLSGNKLTAIPTTIA------------------------ 720

  Fly   301 SATRFHELHVQRHTNVTILFADI-----VNFTPLSSS-----LTASDLVKTLNDLFGRFDQIAQE 355
            :..|.|.|  ..|.|...:|.:|     :.|..||.:     |....|..||.||    |.....
Mouse   721 NCKRLHTL--VAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDL----DLTGNT 779

  Fly   356 NQCLRIKILGDCYYCVSGLPI-SRPQHATNCV------NMGLQMIDAIRHVREATGINVDMRIGI 413
            |..|..|.| |.:..::.|.| .:|..||:..      :.||..:...|:....:.:.:|
Mouse   780 NLVLEHKTL-DMFSHITALKIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMD----- 838

  Fly   414 HTGNVLCGVLGLRKWQFDVWSD--------------DVTLANHMESGGVAGRVHITKQTLDFLGD 464
               |...|| |.....||  .|              ||.|....         |.|..|: |:.:
Mouse   839 ---NFAEGV-GAVYGMFD--GDRNEELPRLLQCTMADVLLEEVQ---------HSTNDTV-FMTN 887

  Fly   465 KFEVEQGEGGNRDAYLADHKVESYL---IVPPKPAYTYSVPRVVEC----IEQNDPSPTT----- 517
            .|.|...:.|.....|....:..|:   ...|..:::.:|..|..|    .....|.|.:
Mouse   888 TFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGMCQAVLCRGGKPVPLSKVFSL 952

  Fly   518 ----EETKEIKETDQSHEATDVADV--------LLPVT-----VAPPPAIVDEKMSPTSINSQ-- 563
                ||.:.:|  ||....|:...|        ||..|     :.|.|.|..   :|.:|..:
Mouse   953 EHDPEEAQRVK--DQKAIITEDNKVNGVTCCTRLLGCTYLYPWILPKPHIAS---TPLTIQDELL 1012

  Fly   564 -----------------EAPLHA--PLASAASMSIKELS----------------EEEDEADEAT 593
                             .|..|.  |||:|..:.....|                .||....|..
Mouse  1013 ILGNKALWEHLSYLEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMN 1077

  Fly   594 AVTEP----------LMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSG 648
            .:|.|          |    :|......|.::.|......|..|.|...|...|..:|:..:: |
Mouse  1078 GLTLPGPVGFASTAAL----KDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTV-G 1137

  Fly   649 SESGISNSGAQAQSSNPASVT------PTAAA----------------PAGGAASNSLTV----- 686
            .|:.:.....:..|.:|||..      |:.|.                |..|..:|...|
Mouse  1138 LEASLLPRPERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVD 1202

  Fly   687 -----AEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMT 746
                 ...||.|.............:|.|.:|..|. |:.|::||..       :..||...::.
Mouse  1203 IHCCRGREPESSPPLPKNSSNACSEERARGAGFGIR-RQNSVNSGIL-------LPANRDKMELQ 1259

  Fly   747 KYVECWGADRPFANIAESKLVKNIGLA----SIAMIESNLLPPERKCFNFNFFGPPTELKP 803
            |        .|..:....|.:.|..:.    |:.:||.....|:||.   .:|..||:|:|
Mouse  1260 K--------SPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKT---GYFAAPTQLEP 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	57/260 (22%)
		CYCc	259..467	CDD:214485	55/243 (23%)
		Guanylate_cyc	311..469	CDD:278633	43/188 (23%)
		BASP1	510..667	CDD:283191	43/225 (19%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131
		leucine-rich repeat	285..305	CDD:275380
		leucine-rich repeat	306..332	CDD:275380
		LRR_RI	309..548	CDD:238064	23/106 (22%)
		LRR_8	354..412	CDD:290566
		leucine-rich repeat	356..378	CDD:275380
		leucine-rich repeat	379..401	CDD:275380
		leucine-rich repeat	402..424	CDD:275380
		LRR_8	425..483	CDD:290566	9/29 (31%)
		leucine-rich repeat	425..448	CDD:275380
		LRR_RI	447..714	CDD:238064	66/293 (23%)
		leucine-rich repeat	449..472	CDD:275380	5/18 (28%)
		leucine-rich repeat	474..493	CDD:275380	5/24 (21%)
		leucine-rich repeat	494..513	CDD:275380	5/24 (21%)
		leucine-rich repeat	514..535	CDD:275380	4/20 (20%)
		LRR_8	536..592	CDD:290566	13/60 (22%)
		leucine-rich repeat	536..558	CDD:275380	2/21 (10%)
		leucine-rich repeat	559..581	CDD:275380	9/26 (35%)
		leucine-rich repeat	582..597	CDD:275380	2/14 (14%)
		LRR_8	604..664	CDD:290566	18/72 (25%)
		leucine-rich repeat	604..627	CDD:275380	7/30 (23%)
		leucine-rich repeat	628..653	CDD:275380	7/29 (24%)
		leucine-rich repeat	654..677	CDD:275380	3/22 (14%)
		LRR_8	676..735	CDD:290566	19/85 (22%)
		leucine-rich repeat	678..701	CDD:275380	3/23 (13%)
		leucine-rich repeat	702..724	CDD:275380	8/45 (18%)
		leucine-rich repeat	747..768	CDD:275380	5/20 (25%)
		PP2Cc	816..1065	CDD:238083	51/274 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900