DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy5

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1320	Identity:	418/1320 - (31%)
Similarity:	598/1320 - (45%)	Gaps:	373/1320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQ-----TMLLVLAALISGSILT 126
            |..||.||..||.:|     .||.|:|.:|.:.: ::...|..:     ..|.||||.: |.||
Mouse   227 LERLYQRYFFRLNQS-----SLTMLMAVLVLVCL-VMLAFHAARPPLQIAYLAVLAAAV-GVIL- 283

  Fly   127 ALQFPAVLSSPAA------ALA-FAIVTTFSLGTIAAITGDELAPLPMYA---------LFLCIH 175
               ..|||.:.||      .|| :|::.......:..:    |.|.|..|         ....|:
Mouse   284 ---IMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGL----LLPQPRSASEGIWWTVFFIYTIY 341

  Fly   176 SMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHN 240
            ::||:....:|:..:.::|:|:...:.|:......|..|...:::.:..::.|:.....::.:..
Mouse   342 TLLPVRMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQR 406

  Fly   241 RTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRF 305
            :....||..|:.|:..:.|.:|||:|||||:|.::|.|:|..|..|..|             ..|
Mouse   407 QAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQED-------------MMF 458

  Fly   306 HELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYC 370
            |::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.|||||||||||||
Mouse   459 HKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYC 523

  Fly   371 VSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSD 435
            |||||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:
Mouse   524 VSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN 588

  Fly   436 DVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYS 500
            |||||||||:||.|||:||||.||::|...:|||.|.||:|:|||.:|.:|::||
Mouse   589 DVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDRNAYLKEHSIETFLI---------- 643

  Fly   501 VPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEA 565
                :.|         |::.||                              ||.....:|.|.
Mouse   644 ----LSC---------TQKRKE------------------------------EKAMIAKMNRQR- 664

  Fly   566 PLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESV 630
                                          |..:.|         .|...|..|...:......|
Mouse   665 ------------------------------TNSIGH---------NPPHWGAERPFYNHLGGNQV 690

  Fly   631 AKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRR 695
            :|.          :...|.|.. .:..|| :|:||..                    |..|...|
Mouse   691 SKE----------MKRMGFEDP-KDKNAQ-ESANPED--------------------EVDEFLGR 723

  Fly   696 KLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFAN 760
            .:..:.:    ||.||.                      ||
Mouse   724 AIDARSI----DRLRSE----------------------HV------------------------ 738

  Fly   761 IAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHF 825
                                                     :.|.:.:|....|..|..|.|..|
Mouse   739 -----------------------------------------RKFLLTFREPDLEKKYSKQVDDRF 762

  Fly   826 RFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLS------------------- 871
            ...:.||.::||.:..||:.::..:|.:|...|:.|:.|||.:::|
Mouse   763 GAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFVSVIYACVKLFPTPLQTLSRK 827

  Fly   872 ------NMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNIL-------------ISSCAVF- 916
                  |.::..|...|        :|..|.::.:.|....|::             :::|.|.
Mouse   828 IVRSKKNSTLVGVFTIT--------LVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVME 884

  Fly   917 SVINYTVPD--GVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAA 979
            |..||::.|  |....|..|     .||...|..|.|                       :||.|
Mouse   885 SAFNYSLGDEQGFCGSPQPN-----CNFPEYFTYSVL-----------------------LSLLA 921

  Fly   980 ISAFLRSGFILKLIAM--------LVAVIAQVTVLGYSDLFEMYNDANITHG-----------LP 1025
            .|.||:...|.||:.|        |:..:..||:...:||....|..:.::.           :.
Mouse   922 CSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVA 986

  Fly  1026 LEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAT 1090
            |::...:::.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.
Mouse   987 LKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAA 1051

  Fly  1091 HFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPK 1154
            |||..| |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:
Mouse  1052 HFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDR 1116

  Fly  1155 FSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRES 1219
            |..:||||||.||||.||||.....|          |..:.| :..:.:||:.||..:..||..|
Mouse  1117 FRQLEKIKTIGSTYMAASGLNDSTYD----------KAGKTH-IKAIADFAMKLMDQMKYINEHS 1170

  Fly  1220 FQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYE 1284
            |..|:::||||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|....|:
Mouse  1171 FNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQ 1235

  Fly  1285 CECRGLTYVKGKGNLVTYFV 1304
            .||||:..|||||.::|||:
Mouse  1236 LECRGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	63/242 (26%)
		CYCc	259..467	CDD:214485	126/207 (61%)
		Guanylate_cyc	311..469	CDD:278633	109/157 (69%)
		BASP1	510..667	CDD:283191	21/156 (13%)
		CYCc	1079..1283	CDD:214485	110/204 (54%)
		Guanylate_cyc	1101..1305	CDD:278633	109/204 (53%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	64/259 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	126/207 (61%)
		Guanylate_cyc	461..622	CDD:278633	109/160 (68%)
		DUF1053	669..761	CDD:283888	28/223 (13%)
		CYCc	1037..1238	CDD:214485	112/211 (53%)
		Guanylate_cyc	1063..1257	CDD:278633	109/204 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810