DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and ADCY4

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	1304	Identity:	429/1304 - (32%)
Similarity:	621/1304 - (47%)	Gaps:	355/1304 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LLTSLLACVVSIIIGIVY--GQHLVQT---MLLVLAALISGSILTAL----QFPAVLSSPAAALA 142
            ||..::.|.::.::.:.:  |:.|...   :..||.||...|:|..|    |.....:.|.:.|.
Human    32 LLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLV 96

  Fly   143 FAIVTTFSLGTIAAITGDELAPLPMYALFLCI----HSMLPISWPVSVVLALFMTAIHIV---YR 200
            :  |...:||.....||..::.....:.||.:    ::|||:....:.|..|..:..|::   ..
Human    97 W--VALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLY 159

  Fly   201 IGTSPDYAPN-LPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQE 264
            :|..||..|. ||.|....|:....:|:|:|::.:.:.|...|.....:.:..|.:|:.|::.||
Human   160 LGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQE 224

  Fly   265 QLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPL 329
            .||||::|||:|.|:|..||.::    |...|....|...||.|:|:||..|::|:||||.||.|
Human   225 HLLLSILPAYLAREMKAEIMARL----QAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRL 285

  Fly   330 SSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMID 394
            :|..:..:||..||:|||:|||||:|::|:||||||||||||||||:|.|.||.|||.|||.|..
Human   286 ASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCR 350

  Fly   395 AIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTL 459
            |||.:|.|||::::||:|:|:|:|||||:||:|||:||||.|||||||||:|||.||||||..||
Human   351 AIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATL 415

  Fly   460 DFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIK 524
            ..|...:.||.....:||.||.:....:||::.|:
Human   416 ALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPR------------------------------ 450

  Fly   525 ETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEA 589
                                                                      :|||||
Human   451 ----------------------------------------------------------AEEEDE- 456

  Fly   590 DEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGIS 654
                                         :|:
Human   457 -----------------------------KGT--------------------------------- 459

  Fly   655 NSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGR 719
                                 |||..|:                                 :||.
Human   460 ---------------------AGGLLSS---------------------------------LEGL 470

  Fly   720 KLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLP 784
            |:                  |||..||:|:|.|||.:|||:::...          :.:.::...
Human   471 KM------------------RPSLLMTRYLESWGAAKPFAHLSHGD----------SPVSTSTPL 507

  Fly   785 PERKCFNFN------------------------FFGPPTEL------------KPFTMWYRNTPR 813
            ||:...:|:                        ||....:|            .|.|:::|....
Human   508 PEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEM 572

  Fly   814 EAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIV--------IELNLALLGSLLASFVSLALFLYL 870
            |..||......|::...|.|::|||..::|::|        |..::..|..||..||..:..|..
Human   573 EKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMR 637

  Fly   871 SNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQ 935
            ..:..|.:.......:|   :||:...||:|:.....:|:.:.|:.|:..:         |:|:.
Human   638 CVLKGPKMLHWLPALSG---LVATRPGLRIALGTATILLVFAMAITSLFFF---------PTSSD 690

  Fly   936 TILES-NFSSVFVNSTLEDVQLWEIDYAIPI--APVFLYCCAISLAAISAFLRSGFILKLIAMLV 997
            ...:: |.||:..|.:      ||:..::|:  .|..::||.:...:.|.||...|.|||:.:|:
Human   691 CPFQAPNVSSMISNLS------WELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLL 749

  Fly   998 AVIAQVTVLGYSDLFEMYNDANITHGL-------PLE----------IKGFLLLLVIILVLHTLD 1045
            .:.|..::.       :::.|.::..|       ||:          :.|.:...:....|..|.
Human   750 WLAASCSLF-------LHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLA 807

  Fly  1046 RQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTE-LYHESYSCV 1109
            ||.||..|.|||||.||:.|:||.|||..:.::||||:||||||..|:...|..| |||:||.||
Human   808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECV 872

  Fly  1110 AVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGL 1174
            .|:|||:|::||||.|:::|.:||||||||||||.|||:||.||||||:||||||.||||.|:||
Human   873 CVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGL 937

  Fly  1175 RPGKEDGATSRSFA--DEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAG 1237
                  .|||...|  |.:|:..| :..:||||:||.|.||.||:.||..||||:|||||||:||
Human   938 ------NATSGQDAQQDAERSCSH-LGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAG 995

  Fly  1238 VIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTY 1302
            ||||||||||||.|||||||||:|.||:|::|.||.||..|.:.||.|..||:..|||||.|.||
Human   996 VIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTY 1060

  Fly  1303 FVKT 1306
            |:.|
Human  1061 FLNT 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/218 (27%)
		CYCc	259..467	CDD:214485	122/207 (59%)
		Guanylate_cyc	311..469	CDD:278633	100/157 (64%)
		BASP1	510..667	CDD:283191	6/156 (4%)
		CYCc	1079..1283	CDD:214485	131/206 (64%)
		Guanylate_cyc	1101..1305	CDD:278633	132/205 (64%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	38/130 (29%)
		CYCc	219..422	CDD:214485	122/206 (59%)
		Guanylate_cyc	264..418	CDD:278633	101/153 (66%)
		DUF1053	479..583	CDD:283888	21/113 (19%)
		CYCc	827..1042	CDD:214485	138/221 (62%)
		Guanylate_cyc	864..1063	CDD:278633	132/205 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1788
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	733	1.000	Inparanoid score	I607
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4464
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870