DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-37

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_500171.2	Gene:	gcy-37 / 191658	WormBaseID:	WBGene00001557	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	97/442 - (21%)
Similarity:	185/442 - (41%)	Gaps:	86/442 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 MLPISWPVSVVLALFMTAIHIVYRIGTSPD------YAPNLPM--LFGEIVMLASASVSGLYYRI 233
            |:||:...|::   |:.:.|:.    |..|      |..::||  ...::|||..:.:..:..
Worm   323 MMPINDGNSII---FICSPHVT----TVRDILNLKLYISDMPMHDATRDLVMLNQSRICQMEL-- 378

  Fly   234 MSDAAHNRTVDGTRTGIEQRV-KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQ 297
                  |:.::.|...:::.. :||.::.|.::||...:|..||..::                .
Worm   379 ------NKKLEETMKKMKKMTEELEVKKSQTDRLLFEFVPPVIAEALR----------------A 421

  Fly   298 ASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIK 362
            |.|       :..|..::.:::|.||.:|..:|.:.:.::::..:.|||.|||:|.::::..::.
Worm   422 AKT-------VPAQEFSDCSVIFTDIPDFFTISVNCSPTEIITVVTDLFHRFDRIIEKHKGYKVL 479

  Fly   363 ILGDCYYCVSGLPISRPQHATNCVNMGLQMI-DAIRHVREATGINVDMRIGIHTGNVLCGVLGLR 426
            .|.|.|..|.|:|.:...|..:.:|:.|.:: :|.:.|......:|.:|||:|.|.|:.|::..:
Worm   480 SLMDSYLIVGGVPNANQYHCEDSLNLALGLLFEAKQVVVPKLERSVRLRIGVHCGPVVAGIVSQQ 544

  Fly   427 KWQFDVWSDDV----TLANHMESGGV----AGRVHITKQTLDFLGDKFEVEQGEGGNRDAY--LA 481
            |.:|.|..:.|    ::.:|...|.|    |.|..:||.    |...|..      |.:.|  |.
Worm   545 KPRFCVLGNTVNVTKSICSHSSPGKVLVSNAVRTMVTKH----LKSIFVF------NANGYLELQ 599

  Fly   482 DHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAP 546
            ..||.::.:...:....:.:  |......||......|......|::..|||..|..::.|..|
Worm   600 SGKVLTHFLEKNEKCSVWDI--VDRDKATNDSIDGYRELHSDNGTEEWQEATVAAYRVISVVDA- 661

  Fly   547 PPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEP 598
                ::.|.|.|.           .|.....|:|.........|...:|:||
Worm   662 ----LENKQSRTR-----------KALTRLRSVKRKFRTIQSNDSGVSVSEP 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	24/120 (20%)
		CYCc	259..467	CDD:214485	52/216 (24%)
		Guanylate_cyc	311..469	CDD:278633	45/166 (27%)
		BASP1	510..667	CDD:283191	20/89 (22%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-37	NP_500171.2	HNOB	3..165	CDD:285002
		HNOBA	223..419	CDD:285003	24/110 (22%)
		CYCc	400..577	CDD:214485	48/199 (24%)
		Nucleotidyl_cyc_III	425..609	CDD:299850	50/193 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810