DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-34

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	87/326 - (26%)
Similarity:	153/326 - (46%)	Gaps:	71/326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1020 ITHGLPLEIKGFLLLL-----VIILV---------------------LHTLDRQGEYVAR---TD 1055
            :|.|..|::||.:::|     :|.|.                     ||...|....:.:   :|
Worm   333 LTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQRLSD 397

  Fly  1056 FLWKAKLKVEQEEVETM-------RGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMF 1113
            .....:|:...|::|||       |.....:|:::||..:|...|..|......:|:    .|||
Worm   398 VEVNLQLEANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEHLEPCEYEA----TVMF 458

  Fly  1114 ASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGK 1178
            ..:|.:::.....    |....::||||:....|::::   ..|:.|::|::.:||..||:
Worm   459 CDLPAFQQIIPVC----QPKNIVKLLNEVFFKLDRIVV---LRGVYKVETVSDSYMTVSGI---- 512

  Fly  1179 EDGATSRSFADEKRTEEHNVVILVEFAIALM----SILDSINRESFQRFRLRIGLNHGPVIAGVI 1239
                       ...|.|| ...:...|:.:|    |::|.:|:..   |.|||||:.|.:||||:
Worm   513 -----------PDYTSEH-AENMCHVALGMMWEARSVMDPVNKTP---FLLRIGLHSGTIIAGVV 562

  Fly  1240 GAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENT-AKILMTAGYECECRGLTYVKGKGNLVTYF 1303
            |.:.|:|.::..||.:||:|:|.||.|::|.:..| :|.:.|..:|...||...|||:|::.|||
Worm   563 GTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYF 627

  Fly  1304 V 1304
            :
Worm   628 L 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	59/208 (28%)
		Guanylate_cyc	1101..1305	CDD:278633	63/209 (30%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002
		HNOBA	224..441	CDD:285003	22/107 (21%)
		CYCc	421..609	CDD:214485	60/217 (28%)
		Guanylate_cyc	453..629	CDD:278633	63/206 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810