DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-25

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	341	Identity:	80/341 - (23%)
Similarity:	146/341 - (42%)	Gaps:	61/341 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 ITGDELAPLPMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVML 221
            :.||      :|.|.:||:.:|....|.:..........|::....|:|.: |.:|......:.|
Worm   663 VEGD------IYQLAMCIYQILFYMRPFAERQESIKELAHLLSSQSTAPLH-PKVPEGNSFTMRL 720

  Fly   222 ASASVSGLYYR--------IMSDAAH---NRTVDGT------------RTGIEQRV-----KLEC 258
            .|.......|:        .::||.:   .:.|.||            ...:||.|     :||.
Worm   721 LSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRELEQ 785

  Fly   259 EREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADI 323
            :....|.||..::|..:|..:             |:|          ..:..::|::||:|..|:
Worm   786 DMSVTENLLYQLLPKSVADSI-------------RSG----------KTVVPEQHSSVTLLVVDV 827

  Fly   324 VNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLP-ISRPQHATN-C- 385
            ..||....:.....:::||.:|:..||.|.|:|:..:::.:||.|...||:| :|..:|... |
Worm   828 CQFTKFCEAFIPVHILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICK 892

  Fly   386 VNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAG 450
            :::.||.......||......:.:::||.:|.|..|:||....:|.::.|.|.:|..|.|.|..|
Worm   893 ISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPG 957

  Fly   451 RVHITKQTLDFLGDKF 466
            .:.:::.|.:.|.:||
Worm   958 SIQLSELTANTLMEKF 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	31/159 (19%)
		CYCc	259..467	CDD:214485	54/211 (26%)
		Guanylate_cyc	311..469	CDD:278633	47/159 (30%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346
		PKc_like	473..746	CDD:304357	18/89 (20%)
		SPS1	474..>736	CDD:223589	16/79 (20%)
		HNOBA	<764..805	CDD:285003	10/40 (25%)
		CYCc	790..976	CDD:214485	54/207 (26%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	47/162 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810