DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and gcy-21

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	1013	Identity:	219/1013 - (21%)
Similarity:	368/1013 - (36%)	Gaps:	258/1013 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 WSDDVTL----------ANHMESGGVAGRVHITKQT-LDFL----GDKFEVEQGEGGNRDAYLAD 482
            ||.:..|          .|.|:||......:|:..| ..:|    ||:..|..|.....|..|.:
Worm   235 WSSNANLLRNYLFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLTE 299

  Fly   483 ---HKVESYLIV---PPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLL- 540
               |:|...:::   .|.||               :|:.|.|:.|              :.||:
Worm   300 NDLHEVYKNVVILSDGPPPA---------------EPNSTWEDIK--------------SQVLMK 335

  Fly   541 -PVTVAPP--PAIVDEKMSP---------TSINSQEAPLHAPLASAASMSIKELSEE---EDEAD 590
             |..:.||  ...|.||::|         .||.......:..|...|::...::..|   ..:.|
Worm   336 KPAKMCPPYCNTTVSEKITPRWDRIKLLFDSIQYLADATNDALNIGANIYQSDIFYEYLISRKID 400

  Fly   591 EATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPA--DDLLSMSGSESGI 653
            ..|.|||.:     ||...........:..|..|..|.|:...|.|:..:  :.:.|::....|:
Worm   401 SVTGVTEFI-----DGYGAIVGSIQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGL 460

  Fly   654 S----NSGAQAQS----------SNPASVTPTAAAPAGGAASNSLTVAEA--PERSRRKLSVQGL 702
            |    |..|...:          ..||:.|.......|.|....|.:|.|  .:|.|.:..:..|
Worm   461 SIDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSL 525

  Fly   703 MSFADRRRSSGAFIEGRKLSIHSGESFRS----HAGHVTRNRPSSKMTKYVECWGADRPFANIAE 763
            ....||.:    .|..:..::.|.:|.||    |...|..::.......::|    |...|:...
Worm   526 FFMIDRNQ----IILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIE----DYNNASSIN 582

  Fly   764 SKLVKNIGLASIAMIESNLLPPERKCFNFNFFGP------PTELKPFTMWY------------RN 810
            :..:.|.|..:.|                ..|||      .|.......|:            |.
Worm   583 ASSIFNTGSTARA----------------GPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRT 631

  Fly   811 TPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS---FV--------SL 864
            ...:.:||:  |..|...      :.|.:|.:|..|....:..:|.::.|   ||        ||
Worm   632 VALKRIYRS--DVEFTRS------IRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSL 688

  Fly   865 ALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSK 929
            ...|...:|.:.||..|...::    ::|...||                      ::.|.|...
Worm   689 KDILDNDDMPLDDVFRSQMTKD----IIAGLEYL----------------------HSSPIGCHG 727

  Fly   930 EPSSNQTILESNFS---SVFVNSTLEDVQLWEIDYAIP-------IAPVFLYC------CAISLA 978
            ...|...::::.:.   |.|....|...:.|:.:..:.       .:|..|..      |.:.|.
Worm   728 RLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLV 792

  Fly   979 AISAFLRSGFIL-KLIAML-------------VAVIAQVTVLGYS----DLFEMYNDANITHGL- 1024
            ..|.......:| :|...|             |:::.:..:.|..    |:..:.....|....
Worm   793 QKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETV 857

  Fly  1025 -------PL------EIKGFLLLLVIILVLHTLDRQGEYVAR-TDFLWKAKLKVEQEEVETMRGI 1075
                   ||      :||..|..|.|.|....:|.....:.: ||.|.| .:....||:|..:..
Worm   858 VAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEK-DIAERNEELEGEKAK 921

  Fly  1076 NKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLN 1140
            ::.||:.:||..||.   .|:..:.:..||:....|.|:..|.:.|.    ....:.::.::.||
Worm   922 SEALLKMMLPEVVAD---SLKLGSNVSAESFENCTVFFSDCPGFVEM----SATSKPIDIVQFLN 979

  Fly  1141 EIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFA 1205
            ::...||:::  .:|. :.|::|||..||.||||               ......|:...:....
Worm   980 DLYTVFDRII--DQFD-VYKVETIADAYMVASGL---------------PVPNGNHHAGEIASLG 1026

  Fly  1206 IALMSILDS--INRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRL 1268
            :||:..::|  |.....::.|||||:|.||.:|||:|.:.|:|.::.:|||.||||:|.|:..|:
Worm  1027 LALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRI 1091

  Fly  1269 QTTENTAKIL-MTAGYECECRGLTYVKGKGNLVTYFVK 1305
            ..:....:|| ...|||.|.||:..:||||..:||||:
Worm  1092 NCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVR 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485	12/48 (25%)
		Guanylate_cyc	311..469	CDD:278633	12/50 (24%)
		BASP1	510..667	CDD:283191	37/188 (20%)
		CYCc	1079..1283	CDD:214485	59/206 (29%)
		Guanylate_cyc	1101..1305	CDD:278633	65/206 (32%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822	46/220 (21%)
		PK_GC	612..881	CDD:270894	48/302 (16%)
		HNOBA	<890..938	CDD:400168	14/51 (27%)
		Guanylate_cyc	944..1130	CDD:306677	66/208 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810