DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-15

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	1014	Identity:	218/1014 - (21%)
Similarity:	369/1014 - (36%)	Gaps:	260/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 WSDDVTL----------ANHMESGGVAGRVHITKQT-LDFL----GDKFEVEQGEGGNRDAYLAD 482
            ||.:..|          .|.|:||......:|:..| ..:|    ||:..|..|.....|..|.:
Worm   176 WSSNANLLRNYIFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLTE 240

  Fly   483 ---HKVESYLIV---PPKPAYTYSVPRVVECIEQNDPSPTTEE--TKEIKETDQSHEATDVADVL 539
               |:|...:::   .|.||               :|:.|.|:  |:.:|:.
Worm   241 NDLHEVYKNVVILSDGPPPA---------------EPNSTWEDIKTQVLKKK------------- 277

  Fly   540 LPVTVAPP--PAIVDEKMSP---------TSINSQEAPLHAPLASAASMSIKELSEE---EDEAD 590
             |..:.||  ...:.||::|         .||.......:..|...|::...::..|   ..:.|
Worm   278 -PAKMCPPYCNTTISEKITPRWDRIKLLFDSIQYLADATNDALNIGANIYQSDIFYEHLISRKVD 341

  Fly   591 EATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPA--DDLLSMSGSESGI 653
            ..|.|||.:     ||...........:..|..|..|.|:...|.|:..:  :.:.|::....|:
Worm   342 SVTGVTEYI-----DGYGAIVGSMQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGL 401

  Fly   654 S----NSGAQAQS----------SNPASVTPTAAAPAGGAASNSLTVAEA--PERSRRKLSVQGL 702
            |    |..|...:          ..||:.|.......|.|....|.:|.|  .:|.|.:..:..|
Worm   402 SIDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSL 466

  Fly   703 MSFADRRRSSGAFIEGRKLSIHSGESFRS----HAGHVTRNRPSSKMTKYVECWGADRPFANIAE 763
            ....||.:    .|..:..::.|.:|.||    |...|..::.......::|    |...|:...
Worm   467 FFMIDRNQ----IILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIE----DYNNASSIN 523

  Fly   764 SKLVKNIGLASIAMIESNLLPPERKCFNFNFFGP------PTELKPFTMWY------------RN 810
            :..:.|.|..:.|                ..|||      .|.......|:            |.
Worm   524 ASSIFNTGSTARA----------------GPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRT 572

  Fly   811 TPREAMYRAQPDTHF-RFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS---FV--------S 863
            ...:.:||:  |..| |.:.       |.:|.:|..|....:..:|.::.|   ||        |
Worm   573 VALKRIYRS--DVEFTRSNR-------LEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGS 628

  Fly   864 LALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVS 928
            |...|...:|.:.||..|...::    ::|...||                      ::.|.|..
Worm   629 LKDILDNDDMPLDDVFRSQMTKD----IIAGLEYL----------------------HSSPVGCH 667

  Fly   929 KEPSSNQTILESNFS---SVFVNSTLEDVQLWEIDYAIP-------IAPVFLYC------CAISL 977
            ....|...::::.:.   |.|....|...:.|:.:..:.       .:|..|..      |.:.|
Worm   668 GRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLL 732

  Fly   978 AAISAFLRSGFIL-KLIAML-------------VAVIAQVTVLGYS----DLFEMYNDANITHGL 1024
            ...|.......:| :|...|             |:::.:..:.|..    |:..:.....|....
Worm   733 VQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQET 797

  Fly  1025 --------PL------EIKGFLLLLVIILVLHTLDRQGEYVAR-TDFLWKAKLKVEQEEVETMRG 1074
                    ||      :||..|..|.|.|....:|.....:.: ||.|.| .:....||:|..:.
Worm   798 VVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEK-DIAERNEELEAEKA 861

  Fly  1075 INKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLL 1139
            .::.||:.:||..||.   .|:..:.:..||:....|.|:..|.:.|.    ....:.::.::.|
Worm   862 KSEALLKMMLPEVVAD---SLKLGSNVSAESFENCTVFFSDCPGFVEM----SATSKPIDIVQFL 919

  Fly  1140 NEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEF 1204
            |::...||:::  .:|. :.|::|||..||.||||               ......|:...:...
Worm   920 NDLYTVFDRII--DQFD-VYKVETIADAYMVASGL---------------PVPNGNHHAGEIASL 966

  Fly  1205 AIALMSILDS--INRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGR 1267
            .:||:..::|  |.....::.|||||:|.||.:|||:|.:.|:|.::.:|||.||||:|.|:..|
Worm   967 GLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLR 1031

  Fly  1268 LQTTENTAKIL-MTAGYECECRGLTYVKGKGNLVTYFVK 1305
            :..:....:|| ...|||.|.||:..:||||..:||||:
Worm  1032 INCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVR 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485	12/48 (25%)
		Guanylate_cyc	311..469	CDD:278633	12/50 (24%)
		BASP1	510..667	CDD:283191	35/188 (19%)
		CYCc	1079..1283	CDD:214485	59/206 (29%)
		Guanylate_cyc	1101..1305	CDD:278633	65/206 (32%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	44/220 (20%)
		PK_GC	553..822	CDD:270894	49/303 (16%)
		HNOBA	<831..879	CDD:400168	14/51 (27%)
		Guanylate_cyc	885..1071	CDD:306677	66/208 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810