DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-14

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	89/360 - (24%)
Similarity:	157/360 - (43%)	Gaps:	73/360 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 IHIVYRIGTS-PDYAPNLPMLFGEIVMLASASVSGLYYRIM------SDAAHNRTVDGTRTGIEQ 252
            :|::....|. |...|::..:.|.:..:.....|.|...:.      :........|.|:..:|
Worm   776 LHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDRTKELVE- 839

  Fly   253 RVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVT 317
                  |:::.:.||..::|..:|.::|.              ||.....| |.:        ||
Worm   840 ------EKKKSDVLLYRMLPKMVADKLKL--------------GQTVEPET-FEQ--------VT 875

  Fly   318 ILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLP-ISRPQH 381
            |.|:|:|.||.|:...|...:|..||||:..||.|.::|...:::.:||.|.|||||| .:..:|
Worm   876 IFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEH 940

  Fly   382 ATNCVNMGLQMIDAIR--HVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 444
            ..:...|.|..:.::.  .|:......:::||||:.|:|:.||:||...::.::.|.|..|:.||
Worm   941 IRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRME 1005

  Fly   445 SGGVAGRVHITKQTLDFLGDKFEVEQGEGG----NRDAYLADHK--VESYLIV------------ 491
            |.|..|::|:|.:....|      .|..||    :|...:...|  :|:|.::
Worm  1006 SNGKPGKIHVTAEANQML------TQVVGGFRTESRGEVIIKGKGVMETYWLLGEQSRISVSAQA 1064

  Fly   492 ----PPKPAYTYSVPRVVECIEQNDPSPTTEETKE 522
                .|:|....||..:...||:     .:|||::
Worm  1065 PREKTPEPPRRQSVRSISPIIEK-----MSEETQK 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	16/100 (16%)
		CYCc	259..467	CDD:214485	63/210 (30%)
		Guanylate_cyc	311..469	CDD:278633	53/160 (33%)
		BASP1	510..667	CDD:283191	3/13 (23%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347
		ANF_receptor	43..418	CDD:279440
		PKc_like	535..800	CDD:304357	5/23 (22%)
		HNOBA	<817..860	CDD:285003	8/49 (16%)
		CYCc	839..1031	CDD:214485	67/227 (30%)
		Guanylate_cyc	866..1053	CDD:278633	62/201 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810