DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and gcy-9

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	675	Identity:	150/675 - (22%)
Similarity:	261/675 - (38%)	Gaps:	183/675 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   710 RSSGAFIEGRKLSIHS----GESFRSHAGHVTRNRPSSKMTKYVECWGADRPFAN-----IAESK 765
            |.|...:||:..|.||    .:|..|.:|.:     :||....:   .|.:..:|     |...:
Worm   505 RESIKMLEGKSKSEHSLASKSQSSGSFSGSM-----NSKQNGLI---AAKQAVSNGVKLAIKRYQ 561

  Fly   766 LVKNIGLASIAMIESNLLPPERKCFNFNF-------FGPPTELKPFTMWY---RNTPREAMYRAQ 820
            .|:||   :....|..||...:.|.|.|.       |....|.  ..||.   |.:..:.::..:
Worm   562 QVRNI---TFPKSELRLLKELKICENDNLNKFYGISFNQQNEF--IVMWVLCSRGSLEDILFNDE 621

  Fly   821 P------DTHFRFDLICAF-------VLFLSLAVVQLIVIELNLALLGSLLASFVSLAL------ 866
            .      ...|..|::...       :|...:..:|..:::.|..:   .|.:|.:.|:
Worm   622 LKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTV---KLTNFATEAVIFEKLD 683

  Fly   867 ------FLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPD 925
                  |:...:.|..||       :.|.:..|..:||:.|..::..|         |...|:|:
Worm   684 HNELRPFINTDSESADDV-------SDPTKDFARKKYLQQAPEIIREI---------VTTKTIPE 732

  Fly   926 GVSK-----------------EPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCC 973
            |...                 ||     ..|.|.|   :|..:|.:.:...|..: |.|.|
Worm   733 GSQSADIYALGMVLYQILFRVEP-----FHERNKS---INKLMETLAMANDDDQL-IRPTF---- 784

  Fly   974 AISLAAISAFLRSGFILKLIAMLVAVIAQVTVL--GYSDLFEMYNDANI-THGLPLEIKGFLLLL 1035
                  .|:....|:.|:|::.:.|...::..:  ....:..|.| ||: :.|     ||
Worm   785 ------PSSNTGEGYNLQLLSCIEACWLEIPEMRPPIKKVRTMVN-ANLKSTG-----KG----- 832

  Fly  1036 VIILVLHTLDRQGEYVARTDFLWK---AKLKVEQEEVETMRGINKILLENILPAHVATHFLHLER 1097
              .||...:....||.|..:.:.:   |.|:..|::.:.       ||.::||..:|.   .|:.
Worm   833 --SLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQADR-------LLNSMLPKSIAE---DLKI 885

  Fly  1098 STELYHESYSCVAVMFASIPNYKEFYDETDVNKQG--LECLRLLNEIICDFDKLLLKPKFSGIEK 1160
            ...:..:.|||..|:|:.|..:      |.::...  |:.:..||::...||.::.|   ....|
Worm   886 GKPVLPQLYSCATVLFSDIRGF------TRISSTSTPLQVVTFLNDMFSGFDAIIAK---HDAYK 941

  Fly  1161 IKTIASTYMCASGLRPGKEDGATSRSFAD---EKRTEEHNVVILVEFAIA-----LMSILDSINR 1217
            ::||...||..||: |.:...:.:::.||   :.|      ..:..|.:|     ||.:
Worm   942 VETIGDAYMIVSGV-PTENGNSHAQNIADVALKMR------AFICNFKLAHRPEELMMV------ 993

  Fly  1218 ESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKIL--MT 1280
                    |||.:.|||.|||:|...|:|.::.:|||.||||:|.||..::|.:|....:|  ..
Worm   994 --------RIGFHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFF 1050

  Fly  1281 AGYECECRGLTYVKGKGNLVTYFVK 1305
            ..::...||...|||||..:||:::
Worm  1051 PQFQMVERGKIEVKGKGECLTYYLE 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	59/215 (27%)
		Guanylate_cyc	1101..1305	CDD:278633	62/215 (29%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141
		ANF_receptor	69..404	CDD:279440
		PKc_like	550..820	CDD:304357	54/312 (17%)
		HNOBA	<837..883	CDD:285003	11/55 (20%)
		CYCc	862..1054	CDD:214485	60/231 (26%)
		Guanylate_cyc	889..1076	CDD:278633	62/217 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810