DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-5

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	449	Identity:	103/449 - (22%)
Similarity:	185/449 - (41%)	Gaps:	112/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 VTTFSLGTIAAITGDELAPLPMYALF---------LCIHSMLPIS--WPVSVVLALFMT------ 193
            :|.|.||.:.    :|..|.....|:         |.||.|.|.:  :..:::.:..:|
Worm   691 LTDFGLGALL----EEHTPSKKRLLWAAPEVLRGSLTIHQMDPSADVYSFAIIASEILTKREAWD 751

  Fly   194 -------AIHIVYRI--GTSPDYAPNLPM-------------------------------LFGEI 218
                   |..|:|.:  |.:....|.|.:                               |..|:
Worm   752 ISNRKEGADEILYMVKKGGNRTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLSEM 816

  Fly   219 VMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVK-LECEREQQEQLLLSVIPAYIAAEVKRS 282
            ....:.::....:.::.:......||     ||:|.| |..|:::.:.||..::|..:|..:|
Worm   817 TPRGNTNLMDHVFNMLEEYTSTLEVD-----IEERTKELTLEKKKADILLSRMLPKQVAERLK-- 874

  Fly   283 IMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFG 347
                        .||.         :..:....||:||:|:|.||.|::..:...:|..||||:.
Worm   875 ------------AGQT---------VEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYS 918

  Fly   348 RFDQIAQENQCLRIKILGDCYYCVSGLPISRP-QHATNCVNMGLQMID-----AIRHV-REATGI 405
            .||.|.:|:...:::.:||.|.||||||.... .|....|:|.|:.:|     .:.|: ||
Worm   919 NFDTIIEEHGVYKVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPRE---- 979

  Fly   406 NVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQ 470
            .|::||||::|..:.||:||...::.::.|.|..|:.|||.|....:|:::.....|.|.:. .|
Worm   980 KVELRIGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYP-HQ 1043

  Fly   471 GEGGNRDAYLADHK--VESYLIV-----PPKPAYTYSVPRVVECIEQNDPSPTTEETKE 522
            .|..:|...:...|  :|::.::     ..|...|.:.|.:.   ::|.|....|:.|:
Worm  1044 YETSSRGEVIIKGKGVMETFWVLGKTDSDTKSLSTRTTPPIT---DENWPPQMKEDLKK 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	34/200 (17%)
		CYCc	259..467	CDD:214485	63/214 (29%)
		Guanylate_cyc	311..469	CDD:278633	55/164 (34%)
		BASP1	510..667	CDD:283191	4/13 (31%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347
		ANF_receptor	49..426	CDD:279440
		PK_GC	546..816	CDD:270894	20/128 (16%)
		HNOBA	<830..873	CDD:285003	12/47 (26%)
		CYCc	852..1042	CDD:214485	63/217 (29%)
		Guanylate_cyc	879..1067	CDD:278633	60/192 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810