DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-4

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	343	Identity:	79/343 - (23%)
Similarity:	147/343 - (42%)	Gaps:	74/343 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTN 315
            |:..:|..|:::.:.||..::|..:|..:|              .|||         :..:....
Worm   848 ERTKELTLEKKKSDILLGRMLPKQVAERLK--------------AGQA---------VEPESFDL 889

  Fly   316 VTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLP-ISRP 379
            ||:.|:|:|.||.|:|..:...:|..|||:|..||.|.:::...:::.:||.:.|||||| .:..
Worm   890 VTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHDVYKVESIGDGFLCVSGLPNRNGM 954

  Fly   380 QHATNCVNMGLQMIDAIRHVR--EATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANH 442
            :|....|.|.|..::..|:.|  ......|::|:||::|..:.||:||...::.::.|.|..|:.
Worm   955 EHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVNTASR 1019

  Fly   443 MESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHK--VESYLIVPPKPAYTYSVPRVV 505
            |||.|....:|:::.....|.:.:.. |.|..:|...:...|  :|:|.::........|.|.:
Worm  1020 MESNGKPSMIHMSEAAHSLLVNNYPY-QFETNSRGEVIIKGKGVMETYWLLGKMSLSNQSTPPI- 1082

  Fly   506 ECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAP 570
                                |..:|:...:|            :..|.:::..|..|
Worm  1083 --------------------TKVNHKPRKIA------------SFTDSELTNYSFRS-------- 1107

  Fly   571 LASAASMSIKELSEEEDE 588
                .|..::.||:.:||
Worm  1108 ----VSPYVENLSDNDDE 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	8/37 (22%)
		CYCc	259..467	CDD:214485	58/210 (28%)
		Guanylate_cyc	311..469	CDD:278633	49/160 (31%)
		BASP1	510..667	CDD:283191	11/79 (14%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347
		ANF_receptor	49..423	CDD:279440
		PKc_like	558..819	CDD:304357
		HNOBA	<834..876	CDD:285003	7/27 (26%)
		CYCc	855..1047	CDD:214485	58/215 (27%)
		Guanylate_cyc	882..1070	CDD:278633	55/188 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810