DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	339	Identity:	88/339 - (25%)
Similarity:	149/339 - (43%)	Gaps:	50/339 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 PDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRT---GIEQRVK-LECEREQQEQ 265
            |:..|....:..::..|.|...:.|     .|...|...:.|.|   .||:|.| |..|:::.:.
Worm   810 PEDRPTAENICSQMKGLVSKQKTNL-----MDHVFNMLEEYTSTLEEEIEERTKELTLEKKKADI 869

  Fly   266 LLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLS 330
            ||..::|..:|..:|              .||.         :..:...:||:.|:|:|.||.|:
Worm   870 LLSRMLPKQVAERLK--------------AGQT---------VEPEGFDSVTVFFSDVVKFTILA 911

  Fly   331 SSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRP-QHATNCVNMGLQMID 394
            |..:....|..||||:..||.|.:::...:::.:||.|.||||||.... .|....|:|.|:.::
Worm   912 SKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFME 976

  Fly   395 -----AIRHV-REATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVH 453
                 .|.|: ||    ||::|||:::|..:.||:||...::.::.|.|..|:.|||.|....:|
Worm   977 YCKSFNIPHLPRE----NVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIH 1037

  Fly   454 ITKQTLDFLGDKFEVEQGEGGNRDAYLADHK--VESYLIVPPKPAYTYSVPRVVECIEQNDPSPT 516
            :|......|...:. .|.|..:|...:...|  :|::.:   ...:....|..:..|......|.
Worm  1038 LTNDAHSLLTTHYP-NQYETSSRGEVIIKGKGVMETFWV---HGRFGEMEPTELRSISNRSTPPV 1098

  Fly   517 TEETKEIKETDQSH 530
            |.: :.|.....||
Worm  1099 TND-RWIPNPSSSH 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	20/87 (23%)
		CYCc	259..467	CDD:214485	62/214 (29%)
		Guanylate_cyc	311..469	CDD:278633	54/164 (33%)
		BASP1	510..667	CDD:283191	5/21 (24%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347
		ANF_receptor	53..432	CDD:279440
		PKc_like	555..821	CDD:304357	2/10 (20%)
		HNOBA	<840..883	CDD:285003	13/42 (31%)
		CYCc	862..1051	CDD:214485	62/215 (29%)
		Guanylate_cyc	889..1077	CDD:278633	59/195 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810