DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and acy-2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_504553.1	Gene:	acy-2 / 191607	WormBaseID:	WBGene00000069	Length:	1080	Species:	Caenorhabditis elegans

Alignment Length:	1302	Identity:	399/1302 - (30%)
Similarity:	567/1302 - (43%)	Gaps:	438/1302 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IHLNDLYTRYRQRLRKSLF-RSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTAL 128
            :||..:....|:|:..:.. .|.|.|||  |:.|:|...:..:|  :.:..|:|  :|.
Worm   129 LHLPVVIFVSRERIHTNEHDHSALYTSL--CIASVIQFFILPRH--RRIFFVVA--VSW------ 181

  Fly   129 QFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVLALFMT 193
                            ||..|.|  |.||..|   .|.:..||:|            ..|:||
Worm   182 ----------------IVANFLL--IVAINWD---ALNVNTLFMC------------SCLSLF-- 211

  Fly   194 AIH--IVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTR--TGIEQRV 254
             :|  ::..:|...|                            |:.|.||.....:  ..:.:|.
Worm   212 -LHQGVIALVGVVAD----------------------------SNEAGNRAEIARKLTEAVYRRT 247

  Fly   255 KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADA----CQRAGGQASTSATRFHELHVQRHTN 315
            :||..:::||||||||||||:|.:|.:||:...:..    ..|.|...:.:...||:||||.|.|
Worm   248 ELETLKDRQEQLLLSVIPAYLADQVSKSIIQSSSTGSTVEVPRTGKNNTKNHKLFHDLHVQVHDN 312

  Fly   316 VTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQ 380
            |:||||||||||.|::.|||.|||:|||:|:.:||:.||..||:|||.||||||||||:|::||.
Worm   313 VSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVSGMPVNRPN 377

  Fly   381 HATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMES 445
            ||..||.|||:||:.|:.||.|||::|:||||:|||:||||::||||||||:|||||||||||||
Worm   378 HADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMES 442

  Fly   446 GGVAGRVHITKQTLD-FLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIE 509
            .||.|.|||||.|.| .|||...|        ||...|..|.||    .:|.|
Worm   443 AGVPGAVHITKSTKDMLLGDYCIV--------DANTDDPHVVSY----GQPTY------------ 483

  Fly   510 QNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASA 574
                                |        :||
Worm   484 --------------------H--------ILP--------------------------------- 487

  Fly   575 ASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLP 639
                      ::..|.|.||                                  |:.:::.|
Worm   488 ----------DKTSAIERTA----------------------------------SIYRNSRL--- 505

  Fly   640 ADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMS 704
                                  |::||                                :|..||
Worm   506 ----------------------STSPA--------------------------------LQSRMS 516

  Fly   705 FADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESK---- 765
            .                                    .:|::|.||.|||:.||||..:.|
Worm   517 M------------------------------------KAKVSKMVEFWGAETPFANFTKKKFSAS 545

  Fly   766 -----LVKNIG--------LASIAMIESNLLPPERKCFNFNFFG-------PPTELKPFTMWYRN 810
                 :...|.        :.|:.:||:||..     |:||...       |.....|..:|
Worm   546 HDPALITDEIARRPTYINTIPSMTLIENNLTN-----FSFNNINSMFNCELPTIPASPKLLW--- 602

  Fly   811 TP--REAMYRAQPDTHFRFDLICAFVLFLSL--AVVQLIVIELNLALLGSLLASFVSLALFLYLS 871
             |  |:::.....|        |..:.|:.:  |...|::..|   ...|.:...:||..|..:.
Worm   603 -PFSRKSITCNLSD--------CVLLTFVCIPSAFANLLLCSL---YCPSDVLQQISLQQFFTII 655

  Fly   872 NMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDG--VSKEPSSN 934
            .:::..:........||             :..:|..|:|||         :|.|  :..:.|..
Worm   656 GLAMLSLLGRVCSYAGP-------------LITMVAFLLSSC---------IPIGPHIIIKKSKL 698

  Fly   935 QTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAV 999
            :.::..| |.:|:.|.:..:....|.|.:|    :.:.|.:..|....|      ..|:::..|.
Worm   699 EGVMAFN-SLIFLPSCVSHLVSVFILYRLP----YSHRCFLFFADFVIF------QVLLSLFPAY 752

  Fly  1000 IAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKV 1064
            .|:|.| ||.             |..|.:....|.|:::| |..:|....|..:.:.......:.
Worm   753 GAEVYV-GYM-------------GYHLSVVSISLSLLVVL-LFFIDWITNYERKRESACHVSFQN 802

  Fly  1065 EQEEVETMRGINKILLENILPAHVATHFLHLERS-TELYHESYSCVAVMFASIPNYKEFYDETDV 1128
            |:.:||||:.|||||:|||||:.||..||..:|: .|||...:..|.||||||||:|:|:.|.|.
Worm   803 EERDVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDT 867

  Fly  1129 NKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFAD---E 1190
            |:: ||||||||||:|:|||||.|||||.:|||||:.||||.|:||...:.|      :.|   |
Worm   868 NRK-LECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEAD------YDDIYLE 925

  Fly  1191 KRTE-------EH------NVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQ 1242
            |:..       .|      |..:::|||:|:..|||::||:|||.|.||||::.||::|||||||
Worm   926 KQNSGKYNNNIRHGNMAFRNANLMIEFALAMSQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQ 990

  Fly  1243 KPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTP 1307
            |||||||.||||:|||||:.|...::..|.:..::|.|.||..:.||...|||        ||.|
Worm   991 KPQYDIWGNTVNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKG--------VKEP 1047

  Fly  1308 FD 1309
            .:
Worm  1048 ME 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	56/226 (25%)
		CYCc	259..467	CDD:214485	131/212 (62%)
		Guanylate_cyc	311..469	CDD:278633	108/158 (68%)
		BASP1	510..667	CDD:283191	11/156 (7%)
		CYCc	1079..1283	CDD:214485	113/220 (51%)
		Guanylate_cyc	1101..1305	CDD:278633	108/219 (49%)
acy-2	NP_504553.1	CYCc	253..463	CDD:214485	130/209 (62%)
		Guanylate_cyc	308..459	CDD:278633	105/150 (70%)
		CYCc	817..1034	CDD:214485	115/223 (52%)
		Guanylate_cyc	840..1054	CDD:278633	111/225 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157569
Domainoid	1	1.000	233	1.000	Domainoid score	I1361
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I656
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4464
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790