DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-20

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	96/380 - (25%)
Similarity:	166/380 - (43%)	Gaps:	85/380 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 IVYRIGTSPDYAPNLPML-FGEIVMLASASVSGLYYRIMSDA---------------AH-NRTVD 244
            |:|:: ....:.|..|.| .||.|::..|.:     .::.|.               :| |...|
Worm   748 IIYQV-KKGGHNPTRPSLDTGETVVINPALL-----HLVRDCWTERPSERPSIEQVRSHLNGMKD 806

  Fly   245 GTRTGIEQRV--------------------KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMAD 289
            |.:|.:...|                    :|..|:::.:.||..::|..:|.::|.
Worm   807 GRKTNLMDHVFNMLETYASTLEEEVSDRTKELTEEKKKSDVLLYRMLPRMVADKLKL-------- 863

  Fly   290 ACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQ 354
                  ||.....| |.:        |||.|:|:|.||.|:...|...:|..||||:..||.|.:
Worm   864 ------GQTVEPET-FEQ--------VTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIE 913

  Fly   355 ENQCLRIKILGDCYYCVSGLP-ISRPQHATNCVNMGLQMIDAIR--HVREATGINVDMRIGIHTG 416
            :|...:::.:||.|.|||||| .:...|..:...|.|..:.::.  .|:......:::||||:.|
Worm   914 QNDVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFRVQHLPAERINLRIGINCG 978

  Fly   417 NVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGG----NRD 477
            :|:.||:||...::.::.|.|..|:.|||.|..|::|:|.:....|      .|..||    :|.
Worm   979 SVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRML------TQVVGGFRTESRG 1037

  Fly   478 AYLADHK--VESYLIVPPKPAYT---YSVPRVVECIEQ-NDPSPTTEETKEIKET 526
            ..:...|  :|::.::..:..||   .:.|:|::..:. ...||..|:..|..||
Worm  1038 EVIIKGKGVMETFWLLGEESGYTAPSKAAPKVIQHRQSIRSISPILEKNAEGSET 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	23/128 (18%)
		CYCc	259..467	CDD:214485	63/210 (30%)
		Guanylate_cyc	311..469	CDD:278633	53/160 (33%)
		BASP1	510..667	CDD:283191	6/18 (33%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347
		ANF_receptor	44..418	CDD:279440
		PKc_like	536..801	CDD:304357	10/58 (17%)
		STYKc	562..801	CDD:214568	10/58 (17%)
		HNOBA	<818..861	CDD:285003	6/42 (14%)
		CYCc	840..1032	CDD:214485	66/220 (30%)
		Guanylate_cyc	867..1054	CDD:278633	61/201 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810