DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and gcy-11

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	106/400 - (26%)
Similarity:	175/400 - (43%)	Gaps:	92/400 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SSPAAALAFA--IVTTFSLGTIAAITGD----ELAPLPMYALFLCIHSMLPISWPVSVVL----- 188
            |.|...|.||  |:..:      |:..|    |||...:|:|.:.::.:.....|....|
Worm   773 SKPDDLLWFAPEIIRRY------AVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDE 831

  Fly   189 -----------ALFMTAIHIV----YRIGT--------SPDYAPNLPMLFGEIVMLASASVSGLY 230
                       ||....||::    |.:.:        .|...|::..: .|::...|..:.|
Worm   832 IIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIKKV-RELLKPLSKGLKG-- 893

  Fly   231 YRIMSDAAHN--RTVDGTRTGIEQRVK-----LECEREQQEQLLLSVIPAYIAAEVKRSIMLKMA 288
                 :.|.|  ..:|..|..:|..:|     ||.||::.|.|||.::|..:|..:|
Worm   894 -----NIADNIMNLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLLPKSVANSLK-------- 945

  Fly   289 DACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIA 353
                  .||         .:..:.:.:|:|.|:|||.||.|||..|...:|..||:|:..||.|.
Worm   946 ------NGQ---------PVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTII 995

  Fly   354 QENQCLRIKILGDCYYCVSGLP-ISRPQHATNCVNMGLQMIDAIR--HVREATGINVDMRIGIHT 415
            .:..|.:::.:||.|..||||| ::...||....:..|:::|:|:  .|.......:.:|||.||
Worm   996 DKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHT 1060

  Fly   416 GNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGG----NR 476
            |.|:.||:|:|..::.::.|.|.:||.|||.|...|:.|:       .|.:|:....||    .|
Worm  1061 GPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQIS-------SDAYELILKCGGYVTEQR 1118

  Fly   477 DAYLADHKVE 486
            :..:..:|:|
Worm  1119 EKIVLKNKLE 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	42/194 (22%)
		CYCc	259..467	CDD:214485	67/210 (32%)
		Guanylate_cyc	311..469	CDD:278633	57/160 (36%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	24/123 (20%)
		CYCc	923..1116	CDD:214485	70/222 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900