DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Npr3

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_032754.2	Gene:	Npr3 / 18162	MGIID:	97373	Length:	536	Species:	Mus musculus

Alignment Length:	158	Identity:	36/158 - (22%)
Similarity:	63/158 - (39%)	Gaps:	44/158 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1103 HESYSCVAVMFASIPNYKEFYDE--TDVNKQGLECLRLLNEIICDF-DKLLLKPKFSGIEKIKTI 1164
            :.|...|.::....|.:::|..|  :.|.||||.....:|..:..| |.:||
Mouse   311 YSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILL------------- 362

  Fly  1165 ASTYMCA--SGLRPG--KEDGAT------SRSF----------ADEKRTEEHNVVILVEFAIALM 1209
               |:.|  ..||.|  |:||..      :|:|          |:..|..:.:||.:.:......
Mouse   363 ---YVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQ 424

  Fly  1210 SIL-DSINRESFQRFRLRIGLNH--GPV 1234
            .:: |...:|.  ||::|..:.:  ||:
Mouse   425 EVIGDYFGKEG--RFQMRSNVKYPWGPL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	36/158 (23%)
		Guanylate_cyc	1101..1305	CDD:278633	36/158 (23%)
Npr3	NP_032754.2	PBP1_NPR_C_like	49..440	CDD:107381	33/146 (23%)
		ANF_receptor	66..419	CDD:279440	29/123 (24%)
		TM_EphA1	471..502	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900