DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-32

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	115/511 - (22%)
Similarity:	213/511 - (41%)	Gaps:	143/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   866 LFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPD--GVS 928
            :|| ::|:|.|       .|:..|.              .|::|.|:.|.|..|   |.|  |:|
Worm   188 VFL-INNLSEP-------RRDSEGS--------------EVSLLTSTNANFPTI---VDDTLGIS 227

  Fly   929 KEPSSN----QTILESNFSSVFVNSTLED-------------VQLWEIDYAIPIAPVFLYCCAIS 976
            .:..|.    ..:::.:...|...|.|.:             ::::||:.  |..|       :.
Worm   228 LDDFSKALPYHFVIDESCKLVQCGSELHNHIPNELLQPGTPILRIFEINR--PQIP-------LD 283

  Fly   977 LAAISAFLRSGFILK----------LIAMLVAVIAQVTVLGYSDLFEMYNDA--NITHGLPLEIK 1029
            ...|..|:.:.|:|:          :.||....:.|       ::..:..||  .:|.|..|::|
Worm   284 FENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQ-------EMETLDEDATNELTQGHHLKLK 341

  Fly  1030 GFLLLL-----VIIL---VLHTLDRQGEYVAR---------------------TDFLWKAKLKVE 1065
            |.::||     :|.|   .:.:::...:|..|                     :|.....:|:..
Worm   342 GQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEAN 406

  Fly  1066 QEEVETM-------RGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFY 1123
            .|::|||       |.....:|:::||..:|...|..|......||:    .|||..:|.:::..
Worm   407 NEQLETMTRELELERQKTDSILKDMLPRRIAQQLLSGEHIEACEHEA----TVMFCDLPAFQQAI 467

  Fly  1124 DETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFA 1188
            .:....    :.:.:||||....|::::   ..|:.|::|::.:||..||:
Worm   468 PQCSPK----DIVNMLNEIFRKLDRIVV---IRGVYKVETVSDSYMAVSGI-------------- 511

  Fly  1189 DEKRTEEHNVVILVEFAIALM----SILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIW 1249
             ...|.|| ...:...|:.:|    |::|.:::..   |.||||::.|.:.|||:|...|:|.::
Worm   512 -PDYTPEH-AENMCHVALGMMWEARSVIDPVSKTP---FLLRIGIHSGTITAGVVGTVHPKYCLF 571

  Fly  1250 SNTVNVASRMDSCGVMGRLQTTE-NTAKILMTAGYECECRGLTYVKGKGNLVTYFV 1304
            ..||.:||:|:|.|:.|::|.:: ...|.:.|..:|...||...||.:|...|||:
Worm   572 GETVTLASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	54/208 (26%)
		Guanylate_cyc	1101..1305	CDD:278633	57/209 (27%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002
		HNOBA	226..440	CDD:285003	40/229 (17%)
		CYCc	419..608	CDD:214485	55/218 (25%)
		Guanylate_cyc	452..627	CDD:278633	55/204 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810