Protein Alignment Ac76E and acy-1

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_497970.1
• Gene: acy-1 / 175622
• WormBaseID: WBGene00000068
• Length: 1253
• Species: Caenorhabditis elegans
• Alignment Length: 1446
• Identity: 383/1446 - (26%)
• Similarity: 590/1446 - (40%)
• Gaps: 393/1446 - (27%)

  Fly    27 GNATQP--KAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLL- 88
            |.:..|  :|.:||..|:.....||....:.|....|.|..:....:::.|.|     |||||:
 Worm    13 GGSCGPSVRAHSSSPRRVPLFERASARWWNPQFRSATLEAQYWKCSFSQLRDR-----FRSGLIY 72

  Fly    89 --------TSLLA--------------CVVSIIIGIV--------YGQHLVQTMLL--VLAALIS 121
                    |..||              |:.:||..:.        |.:..:.|..|  .|..|::
 Worm    73 IAVVIAAWTLYLALFDRTFIQHWIVSLCLCAIIFAMFAFTACAAQYQRFYMPTSFLCTFLICLVT 137

  Fly   122 GSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSV 186
            ..|.:| :..|...:|.|:||.:......:.|:        .|||:|   |||
 Worm   138 LLIFSA-ENQAAFMTPVASLATSFQVVLLIYTV--------IPLPLY---LCI------------ 178

  Fly   187 VLALFMTAIHIVYRIGTSPDYAPNLPMLFG---------------EIVMLASASVSGLYYRIMSD 236
                   .|.|:|.|            ||.               ::|:.|...:.|::..|::.
 Worm   179 -------LIGIIYSI------------LFEILNKNKIGLEEAGYIKLVLHAGVHLLGVHLFILTQ 224

  Fly   237 AAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQ---- 297
            ....:|.......:..|..||.|.:.::.::.||:|..:|.|     :||.|...:|....
 Worm   225 VRQRKTFLKVGQSMLARKDLELETQFKDHMIQSVMPKKVADE-----LLKDASELRRPSASNDSN 284

  Fly   298 -ASTSAT--------------RFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFG 347
             .:::||              :|....:...|||:||||||..||.:||:.:|.:||..||||||
 Worm   285 CRTSNATQVDQPLAKMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFG 349

  Fly   348 RFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIG 412
            |||.:.:.....:|..||||||||:|.|.....||...|.|||.||.|||......|..|:||:|
 Worm   350 RFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVG 414

  Fly   413 IHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRD 477
            ||||.|:||::|.::::|||:|:||||||.|||.|||||||:::.|...|...:|:|  ||.:.|
 Worm   415 IHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIE--EGPDYD 477

  Fly   478 AYLADHKVESYLIVPPKPAYTYSVP-RVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLP 541
            ..|......:...|.|:...|:.:. |:.:.:|        ||..:::|.:..|.........|.
 Worm   478 GPLRMQVQGTERRVKPESMKTFFIKGRINDGVE--------EEVMQVQEVESLHSQKSSKKSTLK 534

  Fly   542 VTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDG 606
            ...|       ||:.....||.      |:.:||......|..:..|.:.:|.:.
 Worm   535 QKWA-------EKLKMNHTNSY------PMRAAAREGGGSLRIKLAERNRSTQLL---------- 576

  Fly   607 KNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPT 671
                 ||.      |......|...|||:|...|.:  :.:||.:..:|             |.:
 Worm   577 -----PKE------SNSICIMEDNRKSASLQALATN--NFNGSNTDTNN-------------TYS 615

  Fly   672 AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAG-- 734
            ....||..:..|:..:|:.       |::|       .||||.     :||:..|.|..:..|
 Worm   616 ERGVAGSVSKKSVAGSESN-------SIKG-------SRSSGL-----QLSLQDGNSDLNSVGGL 661

  Fly   735 --HVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGP 797
              .::.:..::.:|::    ..|..|    :.:|...||.....             |:..|:..
 Worm   662 DTAISHHHNAASLTRF----DTDNNF----DQRLAMVIGQGEGG-------------FDKGFWNH 705

  Fly   798 PTELKPFTMWYRNTPREAMYRAQ-PDTHFRF---------------------------------- 827
            ...|..:|:.:.....|..|||. .|:..|:
 Worm   706 HDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITGSTVNKYRY 770

  Fly   828 -----DLICAFVLF-LSLAVVQLIVIELNLALLGSLLASFVSLALFLYL---------------- 870
                 |:|.|.::| :|.||..:.|....|    ||:|.|...|..|.|
 Worm   771 SGVFIDIIVATLIFVISGAVAIMSVRPFPL----SLIAYFPFAAAILILTIVLIGLPLLARKKSF 831

  Fly   871 --SNMSVPDVHASTTERNGPGQVVASSRYL--RLAMFVVVNILI--------SSCAVFSVINYTV 923
              :|..:|                   |:|  .|.:|:.:.:.|        ..||.. ::||.:
 Worm   832 QCANQWMP-------------------RHLIGLLLIFLPIGVAICIMPLCQSGDCANV-ILNYRL 876

  Fly   924 PDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYA------IPIAPVFLYC---------- 972
                   ..|..|||     ::|.:.....:..|....|      :.||.|| ||
 Worm   877 -------AFSYVTIL-----AIFAHCNFSQLAAWPKTTAAVFIGLLHIAGVF-YCEFNLKHLVEE 928

  Fly   973 ---CAISLAAISAFLRSG--FILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFL 1032
               |.::...|.. :|.|  :.:.|.:.....::|                  ..|.||.|...|
 Worm   929 QDTCNVTAIMIPP-IRKGLNYTIALNSTSARTLSQ------------------DFGSPLFIWELL 974

  Fly  1033 LLLVIILVLHT-LDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE 1096
            |.:::.:||.. |:.|.|...|..|....:.:.:.|.::.:|.....||.|::|||...   .|:
 Worm   975 LDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHAVE---SLK 1036

  Fly  1097 RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161
            ..|: |.|::..|.|:||||.|:.:.|:|.  .:.|.|.||:|||:|.|||:||.:|.|:.||||
 Worm  1037 TDTK-YSENHETVGVLFASITNWNDMYEEN--FEGGREFLRVLNEVIGDFDELLDRPDFTHIEKI 1098

  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRE--SFQRFR 1224
            |||...||.||||.|.::....        ..:|| :..:|:||:|:..:|...|.:  :|. |.
 Worm  1099 KTIGPAYMAASGLNPERKKNML--------HPKEH-LYQMVDFALAVQHVLSVFNEDLLNFD-FV 1153

  Fly  1225 LRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRG 1289
            .::|||.|||.|||||..|..||||.:|||:||||.|.||:.|:|.:::|.:.|:.. ||.|.|.
 Worm  1154 CKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDR-YEFEFRD 1217

  Fly  1290 LTYVKG-KGNLVTYFV 1304
            ...||| .|.:.||.:
 Worm  1218 HIEVKGIDGGMDTYLL 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	55/269 (20%)
		CYCc	259..467	CDD:214485	95/226 (42%)
		Guanylate_cyc	311..469	CDD:278633	83/157 (53%)
		BASP1	510..667	CDD:283191	28/156 (18%)
		CYCc	1079..1283	CDD:214485	88/205 (43%)
		Guanylate_cyc	1101..1305	CDD:278633	90/207 (43%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	28/138 (20%)
		CYCc	297..469	CDD:214485	83/171 (49%)
		Guanylate_cyc	317..503	CDD:278633	90/187 (48%)
		SDF	<773..982	CDD:294387	52/264 (20%)
		CYCc	1016..1215	CDD:214485	91/215 (42%)
		Guanylate_cyc	1041..1235	CDD:278633	90/206 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810