Protein Alignment Ac76E and acy-3

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1204
• Identity: 216/1204 - (17%)
• Similarity: 391/1204 - (32%)
• Gaps: 456/1204 - (37%)

  Fly    91 LLACVVSIIIGIVYGQHLVQTMLLVLAALISGSIL---TALQFPAVLS-SPAAALAFAIVTTFSL 151
            ||...|:||.      |:::...:....:::|.:|   .|...|...| .||....|::.|.||
 Worm    55 LLLSTVTIIF------HILRPARIAAFQILAGIVLLLDVAFALPGYESLFPALLAVFSLYTFFS- 112

  Fly   152 GTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVV----LALFMTAIHIVYRIGTSPDYAPNLP 212
                         ||.||:       |..|..:|:|    ..||:..:|      |:.
 Worm   113 -------------LPFYAI-------LATSTLISIVQTCSFLLFVEPLH------TNE------- 144

  Fly   213 MLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAA 277
             |...||:....:.:|:|....:|..........|...|.....|.:..:..:||.|.:|.::..
 Worm   145 -LLAIIVVHIWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNKLLSSFLPYHLIN 208

  Fly   278 EVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTL 342
            :.:..|.|...                  .|:.:.::.|::.:..:|.|..:.:..::.|..:.|
 Worm   209 QARHQITLYKP------------------HLYNETYSQVSVAYGRLVGFESVLAQCSSIDAARVL 255

  Fly   343 NDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINV 407
            .:|..|.:::|..|.|.|:...|....|  .:|....||||......:::...|...|:|||.:|
 Worm   256 KELDSRIERLAASNGCTRVASEGITAVC--SIPGIDSQHATKLCRFSMELETLINSFRDATGADV 318

  Fly   408 DMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGD--KFEVEQ 470
            .:.|||.:|.|..||:|:.||.:||.......|..|:|......|:::.:|..|||.  :||:|:
 Worm   319 SVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGSTGEFELEK 383

  Fly   471 GEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDV 535
            ...|        .|:..:|                       |||.
 Worm   384 CPIG--------WKLYGHL-----------------------PSPE------------------- 398

  Fly   536 ADVLLPVT-----VAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAV 595
               |.||.     |..|.|:.....|..::|.               ::|.:
 Worm   399 ---LFPVNKRFSLVTVPQAVNRVLQSIVAMNP---------------TLKTM------------- 432

  Fly   596 TEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQA 660
                      |.|.|       .:|
 Worm   433 ----------GTNKK-------RKG---------------------------------------- 440

  Fly   661 QSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHS 725
                                          |:|:.|..:|                  :|...||
 Worm   441 ------------------------------EKSQEKFDMQ------------------KKKVEHS 457

  Fly   726 GESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCF 790
                                                                             
 Worm   458 ----------------------------------------------------------------- 457

  Fly   791 NFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIE---LNLA 852
                    |.:...:..:||...||.|..:.|..|...|..:....:...:..::|:.   .:||
 Worm   458 --------TIISTLSQRFRNPGLEAEYHKETDHWFIPSLAISIFFLVVYGIYHMLVMPRLITSLA 514

  Fly   853 LLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFS 917
            |:...|.....:.|.||:...   ...:....|...|..|:         .:::.:::..|.:
 Worm   515 LIVGALTVMFFILLMLYIDYF---HTFSQFITRTSAGHAVS---------IILIIVILFVCGI-- 565

  Fly   918 VINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISA 982
            |..::.|     :|::.....:::||:.       ...:|.|..|     ||:...::.||
 Worm   566 VNTFSCP-----QPNAPDVCQKAHFSTY-------SFAMWTITTA-----VFVRFPSVYLA---- 609

  Fly   983 FLRSGFILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGL-----------------PLEIKG 1030
                  ||.:|::|                        |:||                 .|::..
 Worm   610 ------ILLIISLL------------------------TYGLQIYVTRPDEFGPREFMTELDLSC 644

  Fly  1031 FLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHL 1095
            ||:.||.::.||:  |:.|.:.|.|||...|...|....:.:..:|..:|.|::|||||...  :
 Worm   645 FLISLVSMVFLHS--RRCERLLRLDFLAVVKGIEETSMKDKLINLNNQMLLNLVPAHVAPGV--I 705

  Fly  1096 ERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEK 1160
            :::.:::|.|:..|.:.:.::..: :...|..:|.        ||.:...||:.:  ..:.|:||
 Worm   706 QKAGDVWHHSHQSVGIAYIAVSGF-DLEGEAGING--------LNYVFSHFDQAI--ANYKGVEK 759

  Fly  1161 IKTIASTYMCASGLRPGKEDGA-----TSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESF 1220
            :|:....|:.|.||.|   |.|     |..:..:...|..|.::.:.:||:.
 Worm   760 VKSANRFYIVAVGLLP---DAAQNVNETPWTIGELMSTLAHFIISISQFAME------------- 808

  Fly  1221 QRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVN 1254
            ..|.::||::.|..:|.|....:|:|:|:..|::
 Worm   809 NEFHVQIGVDCGSTLAFVANTDQPRYEIFGETLD 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	91/388 (23%)
		Guanylate_cyc	310..469	CDD:425528	46/160 (29%)
		Guanylate_cyc	1101..1305	CDD:425528	35/159 (22%)
acy-3	NP_497765.4	AcyC	6..380	CDD:441717	89/385 (23%)
		Nucleotidyl_cyc_III	221..382	CDD:448371	47/162 (29%)
		CYCc	696..873	CDD:214485	40/176 (23%)