DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and gcy-12

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	666	Identity:	149/666 - (22%)
Similarity:	248/666 - (37%)	Gaps:	177/666 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTN 315
            |:.::|:.|:.:.:.||..::|:.:|.              |...||         ::..:....
Worm   984 ERTIELKDEQRRSQHLLQRMLPSSVAE--------------QLLAGQ---------DVIPEAFPP 1025

  Fly   316 VTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQ 380
            |||.|:|||.||.:|...|..::|..||.|:..||.|.:.....:::.:||.|..|||:|..:..
Worm  1026 VTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTM 1090

  Fly   381 --HATNCVNMGLQMIDAIRHV----REATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
              ||.....|.:.::.|:|..    |....:.:  |||:|||..:.||:|....::.::.|.|..
Worm  1091 EYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMI--RIGMHTGPCVAGVVGKTMPRYTLFGDTVNT 1153

  Fly   440 ANHMESGGVAGRVHI---TKQTLDFLGDKFEVEQ-------GEG-------GNRDAYLADHKVES 487
            |:.|||.|.|.|:|.   |::.|..:...|.:|:       |:|       ..|..|.....:|.
Worm  1154 ASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIED 1218

  Fly   488 YLIVP---PKP-----AYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTV 544
            .::||   |:|     ..::.|.|      ::..|..||::.:|.:...:....:..||:.
Worm  1219 KMVVPDIFPRPNLKNRGSSWGVNR------ESSLSLATEKSSQIMKRQSAAMNRNNQDVIY---- 1273

  Fly   545 APPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSE--EEDEADEATAVTEPLMHRDQDGK 607
                              ...||::...::...|.:|:.:  |||...........|..|....|
Worm  1274 ------------------YNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSASLLGSRTSGRK 1320

  Fly   608 NDKEPKANGGHR----GSGDSAASES-------------VAKSAALSLPADDLLSMSGSE-SGIS 654
            .....|.||...    .|..|.||.|             ..:..:.|||..:.|::...| :.::
Worm  1321 KSTASKYNGFSASRMFSSTISNASSSRPSRPSTFDHDTLALRKRSTSLPDGEKLNLEFIETTNLA 1385

  Fly   655 NSGAQAQSSNPASVTPT--AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFAD-------RRR 710
            |:...|..:|.:|:.|.  .|:...|.:|.|    |:|.:|:       ..|:.|       |:|
Worm  1386 NNSVPAIPNNISSLEPVFRKASIIDGYSSQS----ESPSQSQ-------YPSYRDLTTGPHQRKR 1439

  Fly   711 SSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYV----ECWGADRPFANIA--------- 762
            ........||.|:..|::...   .:..|..|..:|..|    .|...| |...:|
Worm  1440 GIATVFPVRKRSLSCGDAVPL---KINENGASGSITTAVSPRSSCRALD-PTMKLAARASSPDEI 1500

  Fly   763 ------ESKLVKNIGLASIAMIESN----------LLPPERKCFNFNFFGPPTEL---------- 801
                  |..|:.|..|     :.||          ..|..|:....:|...|:.|
Worm  1501 IFQEDDEDALIDNDSL-----LTSNGNSKSEDVLRTCPQPRRKNKHSFLRDPSPLAKRFRDASPF 1560

  Fly   802 ---KPFTMWYRNTPRE 814
               |||  |..|...|
Worm  1561 GKKKPF--WNSNKSNE 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	7/37 (19%)
		CYCc	259..467	CDD:214485	60/216 (28%)
		Guanylate_cyc	311..469	CDD:278633	53/166 (32%)
		BASP1	510..667	CDD:283191	32/176 (18%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365
		ANF_receptor	140..519	CDD:279440
		PK_GC-A_B	648..957	CDD:270944
		TyrKc	688..951	CDD:197581
		HNOBA	<967..1012	CDD:285003	7/41 (17%)
		CYCc	991..1183	CDD:214485	60/216 (28%)
		Guanylate_cyc	1018..1206	CDD:278633	56/189 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810