DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gcy-35

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001252131.1	Gene:	gcy-35 / 173202	WormBaseID:	WBGene00001555	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	101/450 - (22%)
Similarity:	193/450 - (42%)	Gaps:	96/450 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHL---NDLYTRYRQRLRKSLFRSGL 87
            :.|:||||:::|.|....| ||..:.::|..: .:.|...|:   .||:..:.....|..|.:.:
Worm   192 NANSTQPKSISSKADSQID-LSTGIYEISSSD-FSLAFPYHICFDPDLFVEHFGNFIKKTFPNAM 254

  Fly    88 LTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLG 152
            ..                    :|.:..|..|:...:  ...:.::.....:...|.:.   .||
Worm   255 RQ--------------------ETRVTDLLELVHPEV--PFSYESIKYYKNSLFVFRLK---GLG 294

  Fly   153 TIAAITGDELAPLPM-----------YALFLCIHSMLPISWPVSVVLALFMTAIHI---VYRIGT 203
            .|.....||...:.:           |.|::|       |..|:.|..|....:|:   ....||
Worm   295 DIVHNANDEAKTVLLKGSMVFIDEGKYILYMC-------SVNVTTVRELIERNLHLSDMQRHDGT 352

  Fly   204 SPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRV-KLECEREQQEQLL 267
            .            :::||..:.        ||....|||::.|...:::.. :||.|:::.::||
Worm   353 R------------DVIMLNQSR--------MSQVELNRTLEETTKKLKKMAQELEIEKQKTDELL 397

  Fly   268 LSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSS 332
            ..::||.:|..::              .|:|         :..:...:.|:||.|||.||.:.:.
Worm   398 CELMPASVADSLR--------------SGKA---------MDAKEFADCTLLFTDIVTFTNICAM 439

  Fly   333 LTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIR 397
            .|..|:|..||||:.|||::...:...:::.:||.|..|.|:|.....||...:|:.:.|:...:
Worm   440 CTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESK 504

  Fly   398 HV-REATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITK 456
            .| ...|...:.:|:|:|.|.|:.||:|::..::.::.|.|.:||.|||.|:..::|:::
Worm   505 LVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSE 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	39/239 (16%)
		CYCc	259..467	CDD:214485	55/198 (28%)
		Guanylate_cyc	311..469	CDD:278633	47/146 (32%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gcy-35	NP_001252131.1	HNOB	3..167	CDD:285002
		HNOBA	218..409	CDD:285003	42/243 (17%)
		CYCc	388..579	CDD:214485	55/199 (28%)
		Guanylate_cyc	415..599	CDD:278633	47/149 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910