DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	473	Identity:	115/473 - (24%)
Similarity:	196/473 - (41%)	Gaps:	116/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQH--LVQTMLLVLAALISGSIL---- 125
            |:||..:...:| ..:|:|.||       :.:|.|:.|..|  :....|.....::.|..:
Mouse   661 LHDLLAQREIKL-DWMFKSSLL-------LDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFVLKVT 717

  Fly   126 -----TALQFPAVLSSPAAA-----LAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPI 180
                 ..|:...||..|.:|     .|..::...||.....:.||      :::|.:.:..::..
Mouse   718 DHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGD------VFSLAIIMQEVVCR 776

  Fly   181 SWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAH------ 239
            |.|.::   |.:|...::.|: .||      |.|...:|.:..|.:..:.......|.|
Mouse   777 STPYAM---LELTPEEVIQRV-RSP------PPLCRPLVSMDQAPMECIQLMTQCWAEHPELRPS 831

  Fly   240 -NRTVD-------GTRTGI--------------------EQRVKLECEREQQEQLLLSVIPAYIA 276
             :.|.|       |.:|.|                    |:..:||.|:::.::||..::|..:|
Mouse   832 MDLTFDLFKSINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVA 896

  Fly   277 AEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKT 341
            ..:|..               .|.....|.|        ||:.|:|||.||.:|:.....::|..
Mouse   897 EALKMG---------------TSVEPEYFEE--------VTLYFSDIVGFTTISAMSEPIEVVDL 938

  Fly   342 LNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQ-HATNCVNMGLQMIDAI-----RHVR 400
            ||||:..||.|...:...:::.:||.|...||||....| ||....||.|.::.|:     ||:.
Mouse   939 LNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMP 1003

  Fly   401 EATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQT---LDFL 462
            |   :.|.:|||:|:|..:.||:||...::.::.|.|..|:.|||.|:..|:|:...|   |..|
Mouse  1004 E---VPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRAL 1065

  Fly   463 GDKFEVE-------QGEG 473
            ...|::|       :|:|
Mouse  1066 DQGFQMECRGRTELKGKG 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	52/271 (19%)
		CYCc	259..467	CDD:214485	65/216 (30%)
		Guanylate_cyc	311..469	CDD:278633	57/166 (34%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	40/207 (19%)
		HNOBA	<854..899	CDD:400168	8/44 (18%)
		CYCc	879..1070	CDD:214485	65/216 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810