DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gc2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	218	Identity:	64/218 - (29%)
Similarity:	114/218 - (52%)	Gaps:	32/218 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTN 315
            |:..:||.|:::.|:||..::|..:|..:|                    ..|.....|.:   :
Zfish   841 ERTEELEIEKQKTEKLLTQMLPPSVAEALK--------------------LGTTVEPEHFE---S 882

  Fly   316 VTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI-SRP 379
            |::.|:|||.||.:|::....::|..||||:..||.:...:...:::.:||.|...||:|: :..
Zfish   883 VSLYFSDIVGFTTISANSEPIEVVDLLNDLYTTFDAVIGNHDVYKVETIGDAYMVASGVPVPNGN 947

  Fly   380 QHATNCVNMGLQMIDAI-----RHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
            :||....||.|.::.|:     ||:.:   :.|.:|||:|||..:.||:||...::.::.|.||.
Zfish   948 RHAAEIANMALDILSAVGTFRMRHMPD---VPVRIRIGLHTGPCVAGVVGLTMPRYCLFGDTVTT 1009

  Fly   440 ANHMESGGVAGRVHITKQTLDFL 462
            |:.|||.|:..|:|:...|:..|
Zfish  1010 ASRMESTGLPYRIHVHSSTVKIL 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	10/37 (27%)
		CYCc	259..467	CDD:214485	61/210 (29%)
		Guanylate_cyc	311..469	CDD:278633	52/158 (33%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..815	CDD:270945
		HNOBA	<824..869	CDD:311573	9/27 (33%)
		CYCc	848..1040	CDD:214485	61/211 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810