DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gucy2f

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	347	Identity:	93/347 - (26%)
Similarity:	152/347 - (43%)	Gaps:	77/347 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 PDYAPNLPMLFGEIVMLASASVSGL----------YYRIMSDAAHNRTVDGTRTGIEQRVKLECE 259
            ||..|....:|.:..::.....:.:          |...:.|....||.:           ||.|
Zfish   797 PDRRPPFDQIFDQFKLINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEE-----------LEVE 850

  Fly   260 REQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIV 324
            :::.|:||..::|..:|..:|..               ||.....|.:        |||.|:|||
Zfish   851 KQRTEKLLSEMLPPSVAEALKTG---------------ASVEPEYFDQ--------VTIYFSDIV 892

  Fly   325 NFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISR-PQHATNCVNM 388
            .||.:||.....::|..||||:..||.:...:...:::.:||.|...||||... .:||....||
Zfish   893 GFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANM 957

  Fly   389 GLQMIDAI-----RHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGV 448
            .|.::.::     ||:.|   :.|.:|||||:|..:.||:||...::.::.|.|..|:.|||.|:
Zfish   958 SLNILSSVGSFKMRHMPE---VPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1019

  Fly   449 AGRVHI---TKQTLDFLGDKFEVE-------QGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPR 503
            ..|:|:   |.|.|..|.|.::::       :|:|..          |:|.:| .|..:|..:|.
Zfish  1020 PYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIE----------ETYWLV-GKANFTKPLPN 1073

  Fly   504 VVECIEQND--PSPTTEETKEI 523
            ..| |:..|  ....|||.|.:
Zfish  1074 PPE-IKPGDNWQDMMTEEIKSL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	17/93 (18%)
		CYCc	259..467	CDD:214485	68/216 (31%)
		Guanylate_cyc	311..469	CDD:278633	58/166 (35%)
		BASP1	510..667	CDD:283191	5/16 (31%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945	4/18 (22%)
		HNOBA	<825..870	CDD:311573	12/55 (22%)
		CYCc	850..1042	CDD:214485	68/217 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810