DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and AgaP_AGAP001985

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_321074.5	Gene:	AgaP_AGAP001985 / 1281135	VectorBaseID:	AGAP001985	Length:	1009	Species:	Anopheles gambiae

Alignment Length:	659	Identity:	146/659 - (22%)
Similarity:	259/659 - (39%)	Gaps:	153/659 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IVYGQHLV-----QTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDE 161
            ||:|..:|     .:::::|..|:|..|....:    |..|..|..|..:...:......:|...
Mosquito   216 IVFGSDMVVRSIGNSLMVILPDLLSKKITDWFE----LRRPLIAFKFQTILNRTNNIFELVTVQS 276

  Fly   162 LAPLP----MYALFLC-------IHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLF 215
            :...|    ...|.|.       :...|.:...:     ::|...:::..:||     |.:|
Mosquito   277 VKKRPENQRKTELVLSEEEEEEEVERRLRLKGQM-----IYMENWYMIMFLGT-----PVMP--- 328

  Fly   216 GEIVMLASASVSGLYYRIMS--DAAHNRTVDGTRTGIEQRVKLECEREQQ--------------- 263
                .|.|...:|||...:|  |.:.:..:.||:..:|  :||..::|||
Mosquito   329 ----KLTSLISTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLALDQEQQKSKKLEESMRKLDEE 387

  Fly   264 ----EQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIV 324
                ::||..:||..:|..::|.  ....|.|                   :...:|:|||:|:|
Mosquito   388 MRRTDELLYQMIPKQVADRLRRG--ENPIDTC-------------------EMFNSVSILFSDVV 431

  Fly   325 NFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMG 389
            .||.:.|.:|..::|..||.::..||.:.:.|...:::.:||.|..|||.|.....||....:|.
Mosquito   432 TFTEICSRITPMEVVSMLNAMYSIFDTLTERNHVYKVETIGDAYMVVSGAPAKEQNHAEKVCDMA 496

  Fly   390 LQMIDAIRHVRE-ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVH 453
            |.||:||..::: :||.::.:|:|:|:|.|:.|::||:..::.::.|.|..|:.|||...|.|:|
Mosquito   497 LDMIEAITDLKDPSTGTHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDSVNTASRMESTSQAMRIH 561

  Fly   454 ITKQTLDFLGDKFEV-EQGE-----GGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQND 512
            |::.|...|...:.| |:||     .|....|..|::                        |...
Mosquito   562 ISESTKHLLSANYRVSERGEIDVKGKGTMKTYWLDYR------------------------ENRP 602

  Fly   513 PSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASM 577
            |....:|  |||.....::......|.:|..:...||........:|...::..:::|:..
Mosquito   603 PLQLLDE--EIKTPAIEYDPGKDRRVSIPSCMFSQPAHKQSLGGLSSAGLEDRRVYSPVTF---- 661

  Fly   578 SIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANG-GHRGSGDSAASESVAK-SAALSLPA 640
                    ||.|..:.|.:...:|  ..|...:|.::|. ||      |...||:. ..:|....
Mosquito   662 --------EDVARRSIANSPVKLH--AFGPRGRENRSNSTGH------AFMHSVSDVFGSLVNDT 710

  Fly   641 DDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSF 705
            ::.|......:.|||:...|.:.:|...:|.|..                 |::.|...|.....
Mosquito   711 EEFLEDLQHRNSISNTLYSASTPSPCPFSPPAQF-----------------RTKSKSCYQAQFMD 758

  Fly   706 ADRRRSSGA 714
            .|....|||
Mosquito   759 KDHELLSGA 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	43/223 (19%)
		CYCc	259..467	CDD:214485	64/227 (28%)
		Guanylate_cyc	311..469	CDD:278633	54/159 (34%)
		BASP1	510..667	CDD:283191	31/158 (20%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
AgaP_AGAP001985	XP_321074.5	HNOB	2..164	CDD:285002
		HNOBA	201..407	CDD:285003	42/213 (20%)
		CYCc	386..574	CDD:214485	61/208 (29%)
		Guanylate_cyc	420..595	CDD:278633	59/174 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810