DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and AgaP_AGAP012161

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_320372.4	Gene:	AgaP_AGAP012161 / 1280524	VectorBaseID:	AGAP012161	Length:	1199	Species:	Anopheles gambiae

Alignment Length:	530	Identity:	123/530 - (23%)
Similarity:	200/530 - (37%)	Gaps:	130/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLY 230
            |:...|.|:...|...|                   ...|:..|:...:...:.:|.......::
Mosquito   767 PLETSFDCVRDCLKECW-------------------AERPEDRPDFKTIRNRLRVLRKGMRPNIF 812

  Fly   231 YRIMSDAAHNRTVDGTRTGIEQRV-KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRA 294
            ..:|  |...:..:.....:::|. :|:.|:::.|.|||.::|..:|.::||.
Mosquito   813 DNMM--AMMEKYANNLEQLVDERTDQLQEEKKKTEALLLEMLPRPVAEQLKRG------------ 863

  Fly   295 GGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCL 359
                       |::..:.:..|||.|:|||.||.:|:..|...:|..||||:..||.|.......
Mosquito   864 -----------HKVEAESYDLVTIYFSDIVGFTSMSAESTPLQVVDFLNDLYTCFDSIIGHYDVY 917

  Fly   360 RIKILGDCYYCVSGLPISRPQ-HATNCVNMGLQMIDAIRH--VREATGINVDMRIGIHTGNVLCG 421
            :::.:||.|..||||||.... ||....:|.||:::|:..  ||......:.:|||||:|.|..|
Mosquito   918 KVETIGDAYMVVSGLPIRNGLIHAAEIASMSLQLLEAVAEFKVRHRPNDRLYLRIGIHSGPVCAG 982

  Fly   422 VLGLRKWQFDVWSDDVTLANHMESGGVAGRVHI---TKQTLDFLGD-KFEVE-----QGEGGNRD 477
            |:||:..::.::.|.|..|:.|||.|...::|.   ||:.||.||. :|:..     :|:|..|.
Mosquito   983 VVGLKMPRYCLFGDTVNTASRMESTGQPLKIHCSLQTKEILDSLGGYQFQERGLVPMKGKGDQRT 1047

  Fly   478 AYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPV 542
            .:|..                            .||......|||..|...|........:|..|
Mosquito  1048 FWLVG----------------------------EDPDARARRTKERTERRGSRALNKYLGMLKSV 1084

  Fly   543 TVAPPPAIVDEKMSPTSI----------NSQEAPLHAPLASAASMSIKELSEEEDEADEA--TAV 595
            |..|.   |...:...|:          :|.|:|.....||.|.     |.:.....|:|  ..:
Mosquito  1085 TNLPG---VRSSLKSRSLGLPRGSLPRSSSLESPKRLRFASGAM-----LEQHRYHRDDALMEVI 1141

  Fly   596 TEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQA 660
            ::..:.|.....:|          |:.|..||....:......|||.               |..
Mosquito  1142 SDSSIRRSDYSISD----------GAEDITASCPCIEHLGTDPPADP---------------AYL 1181

  Fly   661 QSSNPASVTP 670
            .::.|...||
Mosquito  1182 LTNGPTVTTP 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	21/123 (17%)
		CYCc	259..467	CDD:214485	71/214 (33%)
		Guanylate_cyc	311..469	CDD:278633	62/164 (38%)
		BASP1	510..667	CDD:283191	33/168 (20%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
AgaP_AGAP012161	XP_320372.4	ANF_receptor	2..372	CDD:279440
		Periplasmic_Binding_Protein_Type_1	3..397	CDD:299141
		PK_GC-A_B	523..806	CDD:270944	8/57 (14%)
		TyrKc	550..800	CDD:197581	7/51 (14%)
		HNOBA	<815..860	CDD:285003	11/46 (24%)
		CYCc	839..1033	CDD:214485	72/216 (33%)
		Guanylate_cyc	866..1052	CDD:278633	66/185 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810