DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and AgaP_AGAP009087

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_319835.4	Gene:	AgaP_AGAP009087 / 1280041	VectorBaseID:	AGAP009087	Length:	924	Species:	Anopheles gambiae

Alignment Length:	518	Identity:	98/518 - (18%)
Similarity:	164/518 - (31%)	Gaps:	192/518 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 TASDLVK-TLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIR 397
            ||:|.:| ||........|..|: :.:.:.:   |:...|.||.....:....|..|.:.|..:.
Mosquito   437 TANDYMKYTLLSAHRELKQRGQQ-EAVNVTL---CHIARSRLPTEAMSYLPQTVASGRKFILRVA 497

  Fly   398 HVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFL 462
            .|.|::.:.:.     |...||                       :..|..|.::.        |
Mosquito   498 TVGESSAVLIK-----HNRCVL-----------------------LNKGSPARKLG--------L 526

  Fly   463 GDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAY-TYSVPRVVECIEQNDPSPTTEE-----TK 521
            ...|.|...:...::..|.|  .:.||::..:..: ..::..|.|.|.:       ||     .|
Mosquito   527 SANFPVTVPDPEVQEVVLTD--ADEYLVLGNRKLWEVITMETVAEEIRK-------EENILLAAK 582

  Fly   522 EIKETDQSHEA---------------TDVADVL---LPVTVAPPPAIV----------------- 551
            .:::..||:.|               ||| |.|   |..|:...|.::
Mosquito   583 RVQDIAQSYGAEENLSVMIVRFNNLGTDV-DFLMRELRQTIRKKPTLIQGGTGVISGFCKCGCCC 646

  Fly   552 ----------------------DEKMSPT-----SINSQEAPLHAPLASAASMSIKELSEEEDEA 589
                                  .::.||:     :..|:...||....|..|...|| .|..||:
Mosquito   647 ETNNSCCHSAAAVQFVRHPSGRSDRSSPSGQSDQTSGSETVTLHGLPRSKVSDEEKE-REGMDES 710

  Fly   590 DEATAV-------------TEPLMHRD-----------------QDGKNDKEPKANGGHRGSGDS 624
            |.|.:.             |:.|..::                 .:|.::....::|....||.|
Mosquito   711 DSAMSEEQFKCWEYMLEQNTQLLFDKELNTISRGFVGKRTGVTATNGTSESGTNSSGSSGSSGAS 775

  Fly   625 AASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSS---NPASVTPTAAAPAGG------AA 680
            ..::...|:.:.|.|.   |:...|:||:::|.|...|.   ..|..||..:...|.      |:
Mosquito   776 NLTKLQLKNLSTSSPQ---LAQLESDSGLNSSLASGYSGTMMTTARATPFLSKQFGSTRSFHPAS 837

  Fly   681 SNSL-------TVAEAPERSRRKL----------SVQGLM---------SFADRRRSSGAFIE 717
            |.|.       |.|..|    |.:          |:|.||         |..||..|:|..:|
Mosquito   838 SQSYFKPIQYSTPATRP----RPINTGPNAAYFGSLQRLMPYNLEFDGASVQDRYGSNGNVLE 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485	23/133 (17%)
		Guanylate_cyc	311..469	CDD:278633	24/135 (18%)
		BASP1	510..667	CDD:283191	45/256 (18%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
AgaP_AGAP009087	XP_319835.4	leucine-rich repeat	20..50	CDD:275380
		leucine-rich repeat	51..82	CDD:275380
		LRR_8	59..116	CDD:290566
		LRR_4	81..121	CDD:289563
		leucine-rich repeat	83..105	CDD:275380
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	131..152	CDD:275380
		LRR_8	154..235	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		LRR_RI	<171..335	CDD:238064
		leucine-rich repeat	178..200	CDD:275380
		leucine-rich repeat	201..224	CDD:275380
		LRR_8	223..282	CDD:290566
		leucine-rich repeat	225..248	CDD:275380
		leucine-rich repeat	249..271	CDD:275380
		LRR_8	271..326	CDD:290566
		leucine-rich repeat	272..293	CDD:275380
		leucine-rich repeat	294..320	CDD:275380
		PP2Cc	398..602	CDD:214625	38/213 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900