DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and AgaP_AGAP010436

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_311511.4	Gene:	AgaP_AGAP010436 / 1272602	VectorBaseID:	AGAP010436	Length:	1250	Species:	Anopheles gambiae

Alignment Length:	1307	Identity:	790/1307 - (60%)
Similarity:	935/1307 - (71%)	Gaps:	132/1307 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALIS 121
            |:...:|:.||:|||||||||||:|||.:||..|:|:|:.||::..::...|....||..|:.:.
Mosquito    25 EDDILSENSHLDDLYTRYRQRLRRSLFITGLGISILSCITSIVLCALHDAILADVALLAGASTVL 89

  Fly   122 GSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSV 186
            ..||.|||||||::||.|||:|||:||.::|.|:...|.:|||||::||.|.:|:||||||||||
Mosquito    90 CGILVALQFPAVMNSPLAALSFAILTTGTIGAISTFVGTQLAPLPLFALILGVHTMLPISWPVSV 154

  Fly   187 VLALFMTAIHIVYRI-GTSPDYAPN-LPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTG 249
            |||:.:..:||.||| ....|:.|. .|.|..|.|.|||||||.|||||||||||...|||||||
Mosquito   155 VLAVLLCIVHIGYRILSQVHDFPPTFFPQLLAETVFLASASVSSLYYRIMSDAAHIDAVDGTRTG 219

  Fly   250 IEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHT 314
            ||||||||||||||||||||||||||||||||||||||||||||||||   :.|||||:|||||.
Mosquito   220 IEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQ---TQTRFHEMHVQRHN 281

  Fly   315 NVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRP 379
            ||:||:||||||||||..|||||||||||:|||||||||||||||||||||||||||||||:|||
Mosquito   282 NVSILYADIVNFTPLSEQLTASDLVKTLNELFGRFDQIAQENQCLRIKILGDCYYCVSGLPVSRP 346

  Fly   380 QHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 444
            .||.||||||||||||||.||||||.|||||||||||||||||||||||||||||||||||||||
Mosquito   347 HHAANCVNMGLQMIDAIRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 411

  Fly   445 SGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIE 509
            ||||||||||||.|||:|||.||||.|.|.:|::||||||:|:|||||||......||.:....:
Mosquito   412 SGGVAGRVHITKATLDYLGDMFEVEPGGGASRESYLADHKIETYLIVPPKVRNLSDVPALYRHYK 476

  Fly   510 Q-----------------------NDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPP---- 547
            .                       ..|||||  ..:|.|.||.|        ||| .:.||
Mosquito   477 GYRKPPTDLGKPATADSHTPTSNIGTPSPTT--MVQITEPDQEH--------LLP-ALEPPKTPK 530

  Fly   548 ----PAIVDE------KMSPTSINSQEAPLHAPL-ASAASMSIKELSEEEDEADEATAVTEPLMH 601
                |...|:      .:||.:|..::..|..|. |:.||.....|......:.:...:..|.::
Mosquito   531 TPRTPKTPDDVRRSHASISPITIPEEQEQLLPPSPANIASGGHGLLPPPSPNSKQTVQINPPTIN 595

  Fly   602 R---DQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSS 663
            .   |.||..|:          :|::...|| .|.:.|:||.:.:
Mosquito   596 EETVDNDGTADE----------TGEADEGES-RKKSCLTLPVEPI-------------------- 629

  Fly   664 NPASVTPTAAAPAGGAASNSLTVAEAPER-SRRKLSVQGLMSFADRRRSSGA-FIEGRKLSIHSG 726
                                .|....||| ..||||||||::||:||:||.: |.:.||:||.:.
Mosquito   630 --------------------TTNGHLPERVGSRKLSVQGLIAFAERRKSSSSIFGDMRKMSISNI 674

  Fly   727 ESFRS-----HAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPE 786
            :..||     ..|.:.|.||||||||||||||||:|||||.:||:.|||||||||||||||||.:
Mosquito   675 DCLRSPMVATPGGPLLRTRPSSKMTKYVECWGADKPFANITDSKMAKNIGLASIAMIESNLLPED 739

  Fly   787 RKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNL 851
            ..|.....:|||.||:|.|||||||.||.::||||:..|||||||:|:|||::.::|:||.:.|:
Mosquito   740 GYCGECKCWGPPKELQPVTMWYRNTARETLFRAQPEPTFRFDLICSFILFLTIGLIQIIVFKSNV 804

  Fly   852 ALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVF 916
            .::|||.|:.|:|.|||||||..:.::  |....||||||:|:||.||||:|::...||:|||:|
Mosquito   805 VVIGSLSATAVALGLFLYLSNYQMSNL--SPPGNNGPGQVIAASRGLRLAIFLITTALIASCAIF 867

  Fly   917 SVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAIS 981
            ||::..:.   .|..|..:.:...:..  |||:|.||: :::.::| |:|||:||.|||||||:|
Mosquito   868 SVVSRKLR---LKLVSGTKYLAHPDIH--FVNNTTEDM-MYDDEFA-PVAPVYLYMCAISLAAVS 925

  Fly   982 AFLRSGFILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDR 1046
            |||::||::|.:.|.:.|..|.:||..|.|||.|  ..:.:..||..:|.|.||:|..|||||||
Mosquito   926 AFLKAGFLVKGMLMAIFVAIQSSVLWTSSLFEAY--GTLGNSWPLGFQGLLFLLLISAVLHTLDR 988

  Fly  1047 QGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERST-ELYHESYSCVA 1110
            ||||.||||||||||||||||||||||||||||||||||||||.|||..||:. ||||||||.||
Mosquito   989 QGEYAARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAVQELYHESYSSVA 1053

  Fly  1111 VMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLR 1175
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.|||||
Mosquito  1054 VMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMIASGLR 1118

  Fly  1176 PGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIG 1240
            ||||:|||     |||||||||||:|||||||||:.||.||||||||||||||||||||||||||
Mosquito  1119 PGKEEGAT-----DEKRTEEHNVVVLVEFAIALMTALDQINRESFQRFRLRIGLNHGPVIAGVIG 1178

  Fly  1241 AQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVK 1305
            |||||||||||||||||||||||||||:|.||||||:||.|||.|:|||..:|||||.|.|||||
Mosquito  1179 AQKPQYDIWSNTVNVASRMDSCGVMGRVQVTENTAKVLMAAGYSCDCRGPIHVKGKGILTTYFVK 1243

  Fly  1306 TPFDGKL 1312
            ||||.::
Mosquito  1244 TPFDERI 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	144/223 (65%)
		CYCc	259..467	CDD:214485	187/207 (90%)
		Guanylate_cyc	311..469	CDD:278633	143/157 (91%)
		BASP1	510..667	CDD:283191	38/197 (19%)
		CYCc	1079..1283	CDD:214485	181/204 (89%)
		Guanylate_cyc	1101..1305	CDD:278633	179/203 (88%)
AgaP_AGAP010436	XP_311511.4	AC_N	<35..259	CDD:292831	144/223 (65%)
		CYCc	229..429	CDD:214485	184/202 (91%)
		Guanylate_cyc	275..457	CDD:278633	158/181 (87%)
		DUF4746	448..>566	CDD:292550	36/128 (28%)
		CYCc	1021..1221	CDD:214485	181/204 (89%)
		Guanylate_cyc	1044..1243	CDD:278633	179/203 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	438	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75133
Inparanoid	1	1.050	1438	1.000	Inparanoid score	I390
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	1	1.000	-	-		oto108953
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1422
TreeFam	1	0.960	-	-
	13	12.940