DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and AgaP_AGAP000090

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_311062.5	Gene:	AgaP_AGAP000090 / 1272181	VectorBaseID:	AGAP000090	Length:	1641	Species:	Anopheles gambiae

Alignment Length:	1647	Identity:	407/1647 - (24%)
Similarity:	638/1647 - (38%)	Gaps:	520/1647 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 FRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTAL---------QFPAVLSSPA 138
            ||..|...||..:|.::..:..|.....|:|.|...||....|..|         ....:|||..
Mosquito    80 FRFALFYILLCSLVWLLYFLFDGGPTSFTLLTVSIGLIFLFALAGLWVTRTDLYRAHTHLLSSCC 144

  Fly   139 AALAFAIVTTFSLGTIAAITGDELAPLPMYA----LFLCIHSMLPI----------SWPVSVVLA 189
            |.|    :..||| .:..:|.:.|:||..::    :.:.|::::|:          ::.|...:.
Mosquito   145 AVL----LCLFSL-CLLLLTREALSPLGHFSICIEIVMLIYTIIPLPLWLCCTITMAYSVCFEVL 204

  Fly   190 LFMTAIHIVY--RIGTSPDYAP-------NLPMLFGEIVML-----ASASVSGLYYRIMSDAAHN 240
            .|:...|..|  |.|..|..:|       ...:|..|||::     ....:.|:...||:.....
Mosquito   205 SFLHQTHYDYNSRPGGQPTVSPLAAGITTAARLLAEEIVLIRVLIQLCVHLIGIQILIMTVVRMR 269

  Fly   241 RTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMA---------DACQRAGG 296
            .|.......:..|.:||.|::.:|:::.|::|..:|     .::||.:         |.....||
Mosquito   270 GTFMKVGQNLLVRRQLEMEKQLKEKMIHSMMPPKVA-----DLLLKESGSVPKGTSFDQYPAPGG 329

  Fly   297 QASTSA---TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358
            :.:|.:   :.|...|:.|..||:|||||||.||.:||:.||..||:.|||||.|||.:...|.|
Mosquito   330 RRTTPSDLKSLFRPFHMNRMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCLVNGC 394

  Fly   359 LRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVL 423
            .:|..||||||||||.|..||.||..||.|||.||::||.........:.||:|:|||.||||::
Mosquito   395 EKISTLGDCYYCVSGCPEPRPDHAICCVEMGLGMIESIRVFDAQRNEGIKMRVGVHTGTVLCGIV 459

  Fly   424 GLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGE--GGNRDAYLADHKVE 486
            |.::.:|||||:||||||.|||.|...:||::::|..||||.:.:|:||  .|:|..::...:::
Mosquito   460 GTKRVKFDVWSNDVTLANRMESSGKPDQVHVSEETCGFLGDSYIIEEGEEVDGHRTYFVLGKRLD 524

  Fly   487 SYLIVPPKPAYTYSVPRVVECIEQNDPSP--------TTEETKEIKETDQSHEATDVADV---LL 540
            ....: .:...:..:|..:..:..:.|||        |:||..|  .:..|..||:::.:   :.
Mosquito   525 LVGSI-TEGLSSIGLPVDLNLLGASSPSPLDELRDYATSEEHPE--SSCLSRSATNLSSIQPAVP 586

  Fly   541 PVTVAPPPAIVDEKMSPTS-----------------------------INSQEAPLHAP------ 570
            |.:.|.|........||.|                             :|:...|...|
Mosquito   587 PASPAGPVFFSSLHASPVSTPRPRIASLTKMTKFLRSAVSKGDGGGRLLNAGRTPPAPPPVVEKP 651

  Fly   571 --LASAASMSIKELSEEEDEADE------------------------ATAVTEPLMHRDQDGK-- 607
              :.|..|:|....|:::|:.|:                        |.:...|.....|:..
Mosquito   652 KIIISTKSISNGFDSDDDDDDDDRGGGGGCNEDDELVRMGAGAGRGRARSPASPRQSMTQEAPPT 716

  Fly   608 -----NDKEPKANGGHRGSGDSAASESV----------------AKSAALSLPADDLLSMSGSES 651
                 |::..:..||..|.|.......|                :||....:|..:.:..|.|.|
Mosquito   717 TLAMLNERRKQEGGGEAGVGQRKPPGKVLKVGAPEPDCGRICDSSKSCDDDVPCIERMGSSSSNS 781

  Fly   652 G-----------------------------ISNSGAQAQSSNPASVTPTAAAPAGGAASNSL--- 684
            .                             ::|.|..|.   |||..|||:.....|.|...
Mosquito   782 ASNNQNITNGCYQHVPIVIVTPRPSCHTLDVANGGTPAP---PASGAPTASGSCSAARSRDCGKG 843

  Fly   685 -TVAEAPERSR------------------------------------------------------ 694
             ||.|.|..|:
Mosquito   844 PTVGENPHASQGSVFDEIIDVRSYISQSRSDISPFARTGSYRSQADRSSIIHEIALSAGAPGGSN 908

  Fly   695 ---------------------------------------RKLSVQG--LMSFADRRRSSGAFIEG 718
                                                   |.|...|  |...|..|:.||.....
Mosquito   909 SGTFGRPRSSTITTTHHHTCSEAHQHVRHGSVVVCPSSSRLLGADGASLSPSATSRKDSGIRSNS 973

  Fly   719 RK---------------LSIH-------------SGESFRSHAGHVTRNRPSSKMTKYVE----- 750
            |:               ||:|             ||....|.||....::|:..|.....
Mosquito   974 RRSSIQHQLMLMSQTVALSVHRVSGYFTSSQSSLSGAIVTSAAGVPRAHKPNGSMRAGTIATAAN 1038

  Fly   751 ----------------CWGADRPFAN---IAESKLVKNIGLASIAMIESN--------LLPPERK 788
                            |.|...|..:   ....:|.|...|..|..:..|        :.||
Mosquito  1039 SGGAGAAAAAAPGSRCCMGLKEPHPDPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPP--- 1100

  Fly   789 CFNFNFFGPPTELKPFTMWYRNTPREAMYR----------------------AQPDTHFRFDLIC 831
                        |.|.::.:::.|.|..:|                      |.|..:...|::.
Mosquito  1101 ------------LLPISLRFKSRPMEQEFRSKAHRFGSEGGDLLEGGSPPTLATPKYNTYIDMLV 1153

  Fly   832 AFVLFLSLAVVQLIVIELNLALLGS--LLASF-VSLALFLYLSNMSV-----------PDVHAST 882
            :||::|:.:.        :|.||..  .|.|: |.:.:|::.|.:.:           ......|
Mosquito  1154 SFVVYLATST--------SLFLLSPSVYLESYKVWVCIFVFFSTVQLFALFICTKQVCRRTRKPT 1210

  Fly   883 TERNGPGQVVASSRY---LRLAM----FVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILES 940
            ..|:.|  |...|.|   |:||.    :.:...::.|..|.|::                    |
Mosquito  1211 VRRSRP--VATRSCYDCLLQLASAWYPWHICGGILMSLPVISIL--------------------S 1253

  Fly   941 NFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAI--------------SLAAI--SAF--LRSG 987
            ||:.:.|..    .:::|..|..     .:|.|.:              ::|.|  :||  :..|
Mosquito  1254 NFAMMDVTK----FRVFEFHYGF-----LMYICIVHFCNFTQLNWWMRNAMACITSAAFVGIAVG 1309

  Fly   988 FILKLIAMLVAVIAQVTVLG-----------------------YSDLFEMYNDANITHGLPLEIK 1029
            .:::|.|:.||..|....||                       :...|:.:|:..:      ||
Mosquito  1310 HMVELQALEVATAAAAATLGANGTALLAAGGGGGDGAGGNEMLHRAQFDWFNNYRV------EI- 1367

  Fly  1030 GFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLH 1094
             ::.||::::::..|:|:.|...|..|...|....::..|:.|:....:||.||:|.|||...
Mosquito  1368 -YVDLLLLLVLVWFLNREFEIGYRLSFHGSAVANQDKIRVQNMKNQADMLLHNIIPKHVAEQL-- 1429

  Fly  1095 LERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIE 1159
              ::|..|.|::..:.::||||.|:.|.|||:.:.  |.|.||:|||:|.|||:||.:|:|..:|
Mosquito  1430 --KNTAKYSENHHNIGIIFASIVNFNEMYDESYLG--GKEYLRVLNELIGDFDELLARPEFRCVE 1490

  Fly  1160 KIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFR 1224
            |||||.||:|.||||.|      :||.     .|.|| :..|::||:|:..:::|.||:..: |.
Mosquito  1491 KIKTIGSTFMAASGLDP------SSRG-----ETYEH-LYTLLDFALAMQQVVESFNRDLLE-FN 1542

  Fly  1225 L--RIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECEC 1287
            |  |:|.|.|.|.|||||..|..||||.:.|||||||||.||.||:|...:...:| ...|:.|.
Mosquito  1543 LIMRVGYNFGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGVAGRVQVGADCIPVL-GERYDFEP 1606

  Fly  1288 RGLTYVKGKGNLVTYFV--KTP 1307
            ||..|||||.::..|.:  |.|
Mosquito  1607 RGKVYVKGKDHMEVYLLVGKKP 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	54/251 (22%)
		CYCc	259..467	CDD:214485	99/219 (45%)
		Guanylate_cyc	311..469	CDD:278633	86/157 (55%)
		BASP1	510..667	CDD:283191	44/280 (16%)
		CYCc	1079..1283	CDD:214485	93/205 (45%)
		Guanylate_cyc	1101..1305	CDD:278633	94/207 (45%)
AgaP_AGAP000090	XP_311062.5	CYCc	287..494	CDD:214485	94/211 (45%)
		Guanylate_cyc	346..520	CDD:278633	91/173 (53%)
		CYCc	1409..1604	CDD:214485	95/214 (44%)
		Guanylate_cyc	1435..1625	CDD:278633	94/205 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810