DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and AgaP_AGAP002233

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_307952.5	Gene:	AgaP_AGAP002233 / 1269328	VectorBaseID:	AGAP002233	Length:	986	Species:	Anopheles gambiae

Alignment Length:	955	Identity:	199/955 - (20%)
Similarity:	327/955 - (34%)	Gaps:	313/955 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSL--------- 82
            |:..|.|.:.||:|  :..|.....||....:|...|:|  |.|.....:..|.:|
Mosquito   115 GDLVQLKEIPSSSA--SHELKTKAMDLLVMAHGLRHENI--NPLIGWLNEPSRTALVFEHCSRGS 175

  Fly    83 ---------------FRSGLLTSLLA--------------------CVVSI--IIGIV-YGQ-HL 108
                           ||..|||.|:.                    |||..  ::.|. ||. ..
Mosquito   176 LQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHASPLRVHGSLSSRNCVVDARWVLKITDYGMLSF 240

  Fly   109 VQTMLLVLAALISGSIL----TALQ----FPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPL 165
            .:...:..|...:..:|    .||:    :|...:.||...||.|:.     ....:.|:.
Mosquito   241 YEAQGIAPAPRNAKELLWTAPEALRDSRTYPKAGTQPADVYAFGIIM-----QEVVVRGEP---- 296

  Fly   166 PMYALFLCIHSMLP------ISWPVSVVL------ALFMTAIHIVYRI-GTSPDYAPNLPMLFGE 217
                  .|:.|:.|      |..|..::.      |....||:|:.:. ..:|:..|:...:...
Mosquito   297 ------YCMLSLTPDEIIAKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAENPEMRPDFATICER 355

  Fly   218 IVMLASASVSGLYYRIMSDAAHNRTVDGTRT----------GIEQRVK-----LECEREQQEQLL 267
            ...|                .|.|.|:...|          .:|:.::     |:.||::.||||
Mosquito   356 FKQL----------------NHGRKVNFVDTMFQMLEKYSNNLEELIRERTELLDIERKKTEQLL 404

  Fly   268 LSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSS 332
            ..::|:.:|.::|..:.::                       .:....|||.|:|||.||.:::.
Mosquito   405 NRMLPSSVAEKLKLGLAVE-----------------------PEEFAEVTIYFSDIVGFTTIAAH 446

  Fly   333 LTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIR 397
            .|...:|..||||:..||.........:::.:||.|..|||||:..|.||.....|.|.::....
Mosquito   447 CTPVQVVDLLNDLYTCFDATINAYNVYKVETIGDAYMVVSGLPVRTPDHAEQIATMALDLLSQSG 511

  Fly   398 H--VREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLD 460
            |  ||...|:.:.:|||:|||....||:||...::.::.|.|..|:.|||.|.:.|:|:::||.:
Mosquito   512 HFKVRHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQQTCN 576

  Fly   461 FL--GDKFEVE-------QGEGGNRDAYLADHKVESYLI---------VPPKPAYTYSVPRVVEC 507
            .|  ...:.:|       :|:|          |:.:|.:         :||.|.....|..:...
Mosquito   577 LLEKAGGYVIEPRGPIEIKGKG----------KMHTYWLLGKKGFDKALPPPPPIGLDVAILKHS 631

  Fly   508 IEQN--------DPSPTTEETKEIKETDQSHE---ATDVADVLLPVTVAPPP------------- 548
            :.|:        :.:.....|........||.   |.:..||.:.:|...||
Mosquito   632 LFQSQQDHGAKINNASIQSNTCSTANHSSSHSPSVAGESIDVKVEITPPVPPSLDPGQQQQQPGQ 696

  Fly   549 ---AIVDEKMSPTSINS--------------QEAPLHAPLA------------------------ 572
               |::....|..|.:|              :.:||.:|.|
Mosquito   697 DTAAVLSTSFSIESSSSNNTFTLNLGEFGQPKASPLPSPQARKLSEVIADGSFLSAGATFDRLNP 761

  Fly   573 --SAASMS-------IKE-------------LSEEEDEADEAT------------------AVTE 597
              |:||.|       |:|             ||..|:...:.|                  ..|.
Mosquito   762 SPSSASASSTRLFKRIEELIDLSSPYNYYKCLSPSENNLSQCTESRYGSYQLRSDSCSSKPGSTR 826

  Fly   598 PLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQS 662
            .|..:....|:|..| ::||| |....:|..::...:::|:..:.|..| |:.:.|.:
Mosquito   827 FLRRQFSLDKDDVGP-SSGGH-GVATLSAKATLDTISSISVDREQLARM-GTLTSIPS------- 881

  Fly   663 SNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFI----------- 716
               .|.|.:|..|.||....||    |..|.:.....|.|....:...|..:||
Mosquito   882 ---ISSTNSATLPGGGQKQRSL----AMHRQQSASVAQDLEKIEEIPLSPQSFIINHTGGGGGGG 939

  Fly   717 ---EGRKLSIHS-----GESFRSHAGHVTRNRPSSKMTKYVECWG 753
               .....|:.|     |.|||:.|..........::...||..|
Mosquito   940 GGGSSSTSSLQSEVNERGRSFRNGASTAPNGHSGKELRLSVEALG 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	54/305 (18%)
		CYCc	259..467	CDD:214485	65/211 (31%)
		Guanylate_cyc	311..469	CDD:278633	56/161 (35%)
		BASP1	510..667	CDD:283191	43/261 (16%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
AgaP_AGAP002233	XP_307952.5	PKc_like	115..362	CDD:304357	51/281 (18%)
		HNOBA	<373..416	CDD:285003	10/42 (24%)
		CYCc	395..587	CDD:214485	65/214 (30%)
		Guanylate_cyc	422..607	CDD:278633	61/217 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810