Protein Alignment Ac76E and AgaP_AGAP002262

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_307919.5
• Gene: AgaP_AGAP002262 / 1269297
• VectorBaseID: AGAP002262
• Length: 1384
• Species: Anopheles gambiae
• Alignment Length: 1392
• Identity: 408/1392 - (29%)
• Similarity: 641/1392 - (46%)
• Gaps: 314/1392 - (22%)

  Fly    11 TGNGTNATANLIVKADGNATQPKA-MTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRY 74
            :|:|:||          :.|||.. .|.||.:..:.:...|.  ....|...|..:..:.|...:
Mosquito    63 SGSGSNA----------SHTQPHTNNTYSAFKRGNVVKGILC--PSMTNSFRAPSLERSYLTYSH 115

  Fly    75 RQRLRKSLFRSGLLTSLLACVV-SIIIGIVYGQHL-VQTMLLVLAALISGSILTALQFPAVLSSP 137
            ||| :|||....::..:|..|: |:.||...|..: ...:...:..:||..::..|....:.::
Mosquito   116 RQR-QKSLILVNVVDLVLKVVLASVWIGFNSGMTIKPHEVTWSVCCIISNFLICVLGSWRLFAN- 178

  Fly   138 AAALAFAIVTTFSLGTIAAITGD-----ELAPLPMYALFLCI--HSM--LPISWPVSVVLALFMT 193
             ..|.:|.|.|:.|..:....|:     |...|..|.||:..  ::|  ||:.|   .::|..||
Mosquito   179 -NYLHWAAVCTWLLLNLQGFLGEGLGFAEREYLIWYVLFIIFVPYAMLPLPLKW---CMIAGSMT 239

  Fly   194 AI-HIVYRIGTS-----PDYAPN--LPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGI 250
            || |:|.   ||     .|..|:  :..:...:::..:.:.:|:|.:.::|.........|...:
Mosquito   240 AICHLVV---TSLNKFLHDKDPSCIVRQMIANLLLYLAINFAGMYTKYLTDRGQRLAFIETHKAM 301

  Fly   251 EQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTN 315
            |.:.:.|.|.::.::||.|::|.::..::::. |.|..:..|        ..|:|.:|::....|
Mosquito   302 EHKRESEKEYQRTQRLLDSILPMFVNNDIRKE-MYKSPEQAQ--------VDTQFKKLYIYHMDN 357

  Fly   316 VTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI---- 376
            |:||||||..||.|:|..:|..|||.|||||.|||:||::|.|||||:|||||||||....
Mosquito   358 VSILFADIKGFTELASKTSAQQLVKILNDLFARFDKIAEDNHCLRIKLLGDCYYCVSMFDSQSWK 422

  Fly   377 SRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLAN 441
            |||.||...|..||.||.||:.||..|.:.:|||||||:|:|:|||||.:||.|||||:||.:||
Mosquito   423 SRPDHAVCSVETGLHMIKAIKDVRCQTNVELDMRIGIHSGSVMCGVLGEKKWHFDVWSNDVVIAN 487

  Fly   442 HMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVE 506
            |||||||.|||||::.||..|.|.:|||.|.||:||::|....::::||...:|..    ||
Mosquito   488 HMESGGVPGRVHISEATLKCLNDTYEVEPGNGGSRDSHLKMMNIKTFLIKRTEPLR----PR--- 545

  Fly   507 CIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPL 571
                                                                             
Mosquito   546 ----------------------------------------------------------------- 545

  Fly   572 ASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAAL 636
                                     :.||.|....:.:||..|
Mosquito   546 -------------------------KRLMDRQSTVQFEKETAA---------------------- 563

  Fly   637 SLPADDLLSMSGSESGI-SNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQ 700
                     |...||.. .:|...:.:||..:.|.|.|..:||      :|.:....:....:..
Mosquito   564 ---------MRAGESRFRKDSKTPSITSNSTNTTGTTATCSGG------SVVQHNHNNNNNNTTS 613

  Fly   701 GLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAES- 764
            ...:...:|.|        |.:||..|:       .|...|........||.|.    .|.|||
Mosquito   614 SNNNHITKRTS--------KSTIHEDET-------TTDWIPEIPFKNLNECGGG----VNAAESF 659

  Fly   765 KLVKNIGLASI--------AMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQP 821
            :..|:.....:        .||:.::.....|.....:      |..:|:.::::.:|..:....
Mosquito   660 RDKKHTDREDVFTSTEEVDEMIDQSIQINSNKQIRQEY------LYTWTLKFKDSSQEGTFCQLR 718

  Fly   822 DTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERN 886
            :..||.:::|.||:::.:.:.|.::|.....|:.:|     |:..||    ::|..:.....|.:
Mosquito   719 EDMFRSNMLCVFVVWIFIVLCQAVIIPRCTILIVAL-----SITTFL----LTVGCILVMAEEFS 774

  Fly   887 G-PGQVVASSRYL-----RLAMFVVVNILISS---------CAVFSVINYTVPDGVSKEPS---- 932
            | |..:..||..|     |..:||.:.|::.|         |.:..|  ..|||..:..||
Mosquito   775 GLPKFLQQSSSTLVHDRSRRTIFVCLTIILMSIASSMGLMMCDLEEV--DAVPDRSTVSPSYSYY 837

  Fly   933 ------------------------------SNQTILESNFSSVFVNST-LEDVQLWEIDYAIPIA 966
                                          :|:|:.|::     .|:| |...:|.:.|......
Mosquito   838 WQAGGQLNVNSTAITLLRRAVGDALELGALTNRTVSETD-----ANTTELVTDELLDHDETTSTP 897

  Fly   967 PVFLYCC----------AISLAAISAFLRSGFILK---LIAMLVAVIAQVTVLGYSDLFEMYNDA 1018
            |:....|          .:.|.:::..|:..:::|   .||| ||..:.:.:|.:..:|:.|:..
Mosquito   898 PILHPSCVHPEYVVFTWVLCLISLATALKLYYLVKTFMAIAM-VACYSFLILLVFEKVFDSYDLQ 961

  Fly  1019 NI-THGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLEN 1082
            .| ..|:||..:..:||.|.:.::....|..|..:|.||:||.:.:.|...:.:.|.:|.:|::|
Mosquito   962 YIQASGMPLAAQMMILLGVFLTMVTYHARLVEVTSRLDFIWKEQAEKELSNMRSNRHLNDLLIKN 1026

  Fly  1083 ILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFD 1147
            |||.||||::|..||:.|||.:.:....||||||||:|:||.| |: :.|..|:|:|||||.|||
Mosquito  1027 ILPDHVATYYLSEERTDELYAKMHELCGVMFASIPNFKDFYSE-DI-ENGKACIRILNEIISDFD 1089

  Fly  1148 KLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSIL 1212
            .||.:|:|..:|||||:.:|||.||.|      .:|.:|..||:  :|..|..|||||:|:...|
Mosquito  1090 SLLEEPRFETVEKIKTVGATYMAASNL------CSTKKSHVDER--DEEAVCDLVEFALAMRQKL 1146

  Fly  1213 DSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKI 1277
            ..:|:::|..|:||:|::.||:::|||||:||.||||.|||||||||||.|...::|..:.||.:
Mosquito  1147 QEVNKDAFNTFQLRVGISSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWKVQVPDYTAAL 1211

  Fly  1278 LMTAGYECECRGLTYVKGKGNLVTYFV 1304
            |.|.||.|..||...|||||.::||:|
Mosquito  1212 LQTKGYTCVQRGEVNVKGKGLMLTYWV 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	55/240 (23%)
		CYCc	259..467	CDD:214485	108/211 (51%)
		Guanylate_cyc	311..469	CDD:278633	98/161 (61%)
		BASP1	510..667	CDD:283191	12/157 (8%)
		CYCc	1079..1283	CDD:214485	103/203 (51%)
		Guanylate_cyc	1101..1305	CDD:278633	103/204 (50%)
AgaP_AGAP002262	XP_307919.5	AC_N	<82..334	CDD:292831	57/263 (22%)
		CYCc	309..513	CDD:214485	108/212 (51%)
		Guanylate_cyc	350..516	CDD:278633	100/165 (61%)
		DUF1053	631..721	CDD:283888	17/106 (16%)
		CYCc	1020..1218	CDD:214485	105/207 (51%)
		Guanylate_cyc	1045..1240	CDD:278633	103/204 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820