DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Gucy2f

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_446283.1	Gene:	Gucy2f / 116556	RGDID:	620439	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	125/509 - (24%)
Similarity:	210/509 - (41%)	Gaps:	147/509 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLA-------------------CVVS--IIIGIV-YGQHLV 109
            |.|:.|:...:| ..:|:|.||..|:.                   |||.  .::.:. ||.:.:
  Rat   631 LEDILTQDDVKL-DWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNNI 694

  Fly   110 QTMLLVLAALISGSIL--TALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFL 172
            ..||.:.....|...|  ||   |.:|.:|..         ..||:.|   ||      :|:..:
  Rat   695 LEMLRLSEEEPSEEELLWTA---PELLRAPGG---------IRLGSFA---GD------VYSFAI 738

  Fly   173 CIHSMLPISWPVSVVLALFMTAIHI---------VYRIGTSPDYAPNLPMLFGEIVMLASASVSG 228
            .:..::....|..:   :.::|..:         |||...||::||      .|.:.|..
  Rat   739 IMQEVMVRGAPFCM---MDLSAKEVIDRLKMPPPVYRPVVSPEFAP------PECLQLMK----- 789

  Fly   229 LYYRIMSDAAHNR-TVD-----------GTRTGI--------------------EQRVKLECERE 261
               :..::||..| |.|           |.:|.|                    |:..:||.|::
  Rat   790 ---QCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQ 851

  Fly   262 QQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNF 326
            :.|:||..::|..:|..:|:...::                       .:....||:.|:|||.|
  Rat   852 KTEKLLTQMLPPSVAESLKKGCTVE-----------------------PEGFDLVTLYFSDIVGF 893

  Fly   327 TPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLP-ISRPQHATNCVNMGL 390
            |.:|:.....::|..||||:..||.|...:...:::.:||.|...|||| .:..:||....||.|
  Rat   894 TTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSL 958

  Fly   391 QMIDAI-----RHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAG 450
            .::.::     ||:.|   :.|.:|||:|||.|:.||:||...::.::.|.|..|:.|||.|:..
  Rat   959 DILSSVGTFKMRHMPE---VPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1020

  Fly   451 RVHITKQT---LDFLGDKFEVE-------QGEGGNRDAYLADHK-VESYLIVPP 493
            |:|::..|   |..|.:.:|||       :|:|.....:|...| ....|.|||
  Rat  1021 RIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPP 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/286 (20%)
		CYCc	259..467	CDD:214485	63/216 (29%)
		Guanylate_cyc	311..469	CDD:278633	57/166 (34%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF_like	54..435	CDD:107366
		ANF_receptor	75..412	CDD:279440
		PKc_like	545..815	CDD:304357	45/222 (20%)
		TyrKc	565..809	CDD:197581	45/216 (21%)
		HNOBA	<824..869	CDD:285003	9/44 (20%)
		CYCc	848..1040	CDD:214485	63/217 (29%)
		Guanylate_cyc	875..1062	CDD:278633	62/212 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810