DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy9

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	1466	Identity:	386/1466 - (26%)
Similarity:	610/1466 - (41%)	Gaps:	384/1466 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NHNAETA--KTGNGTNATANLIVKADGNATQPK----AMTSSAARMNDA--------------LS 47
            :|:.|.:  .:|:..:....:..|...:.|.||    :::||.:...|:              ..
Mouse    12 HHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRVGGGGRLRRQ 76

  Fly    48 ASLADLSEQE---------NGTTAEDIHLNDLYTRYRQRLRKSLFRSG---LLTSL--------- 91
            ..|..|.|:.         :....|:..|...:.:.::|.|.:||..|   ||.|:
Mouse    77 KKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSK 141

  Fly    92 -------LACVVSIIIGI-------VYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALA 142
                   ..|.:.:.:|.       :|.:|...|.|          .||.|.|...|     |..
Mouse   142 VIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSL----------ALTLLVFALTL-----AAQ 191

  Fly   143 FAIVTTFSLG-------TIAAITGDE-LAPLPMYALFLCIHSMLPISWPVSVVLALFMTAIHIV- 198
            |.:.|..| |       |:.|...|. |:.:..:::.:.:..:|.....:.:.|:||:..::.|
Mouse   192 FQVWTPLS-GRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVL 255

  Fly   199 -----YRIGTSPDY-APNLPMLFGEIVMLASASVS----GLYYRIMSDAAHNRTVDGTRTGIEQR 253
                 |.......| :|....|..|::..|...|.    |::..:||......|.......|...
Mouse   256 FETFGYHFRNEDCYPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHG 320

  Fly   254 VKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMAD-ACQRAGGQASTSATR------------- 304
            ..||.|:..:|:::.||:|..||.:     ::|..| ..:.:..:.:||:.:
Mouse   321 KDLEVEKALKERMIHSVMPRIIADD-----LMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPI 380

  Fly   305 -FHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCY 368
             |....:|:...|:|||||||.||.:|::.:|..||..|||||||||::.::.:|.:|..|||||
Mouse   381 AFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCY 445

  Fly   369 YCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVW 433
            |||:|.|..|..||..|:.|||.||.||....:.....|:||:|:|||.||||:||:|:::||||
Mouse   446 YCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVW 510

  Fly   434 SDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYT 498
            |:||.|||.||..||||:|||::.|..:|.|::|:|.|
Mouse   511 SNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG--------------------------- 548

  Fly   499 YSVPRVVECIEQNDPSPTTEETKEIK-------ETDQSHEATDVADVLLPVTVAPPPAIVDEK-- 554
                ||:|.:.|   |...::.|.:|       ...:||  ...|:.||...     .::|:.
Mouse   549 ----RVIERLGQ---SVVADQLKGLKTYLISGQRAKESH--CSCAEALLSGF-----EVIDDSRE 599

  Fly   555 ---------MSPTSIN--SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKN 608
                     .||.|::  :|.......|.:..|..|....:.|..|:..|.         |:|..
Mouse   600 SSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTV---------QNGCQ 655

  Fly   609 DKEPKANGGHRGSGDSAASESVAKS--AALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPT 671
            | |||            .|..|..|  ..||:|   ||:.....||..||..|....:|
Mouse   656 D-EPK------------TSTKVTSSWLLFLSVP---LLAHPPKASGGPNSKTQNGLLSP------ 698

  Fly   672 AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHV 736
               ||....:||.|                  |..:..:..|.:         :|.|....|...
Mouse   699 ---PAEEKLTNSQT------------------SLCEILQEKGRW---------AGVSLDQSALLP 733

  Fly   737 TRNRPSSKMTKYVECWGADRPFAN-IAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTE 800
            .|.:...:.|        |..|.: |.|..|:|:.           ...|....|:.||.....|
Mouse   734 LRFKNIREKT--------DAHFVDVIKEDSLMKDY-----------FFKPPINQFSLNFLDQELE 779

  Fly   801 LKPFTMWYRNTPREAMYRAQPDTHFR-------FDLICAFVLFLSLAV---------------VQ 843
            ..     ||.:.:|.:.:..|...|.       .|:..:..:||.|::               ..
Mouse   780 RS-----YRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAA 839

  Fly   844 LIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLR------LAM 902
            |.|...:|.|  .:|:..||:.:..:|.:                  |:..:::|.      |..
Mouse   840 LAVFGADLLL--EVLSLIVSIRMVFFLED------------------VMTCTKWLLEWIAGWLPR 884

  Fly   903 FVVVNILIS--SCAVFSVINYTVPDGVSKEPSSNQTILESNFS-SVFVNSTLEDVQLWEIDYAIP 964
            ..:..||:|  :.||:|.|.               :..|:|.. ::|..|            |:.
Mouse   885 HCIGAILVSLPALAVYSHIT---------------SEFETNIHVTMFTGS------------AVL 922

  Fly   965 IAPVFLYCCAISLAAISAFLRSGFI----LKLIAMLVAVIAQVTVLGYSDLFEMYN--------D 1017
            :|.|. ||   :...:|:::||...    ..|:.:|...:.|.:.:..|.|....|        :
Mouse   923 VAVVH-YC---NFCQLSSWMRSSLATIVGAGLLLLLHISLCQDSSIVMSPLDSAQNFSAQRNPCN 983

  Fly  1018 ANITH---------GLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMR 1073
            :::..         |..|.:..|||||::..    |:|:.|...|..:....:..:.:.::::||
Mouse   984 SSVLQDGRRPASLIGKELILTFFLLLLLVWF----LNREFEVSYRLHYHGDVEADLHRTKIQSMR 1044

  Fly  1074 GINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRL 1138
            .....||.||:|.|||...    :.::.|.:::....|:||||.|:.|||:|.  .:.|.||.|:
Mouse  1045 DQADWLLRNIIPYHVAEQL----KVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKECYRV 1103

  Fly  1139 LNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGK-EDGATSRSFADEKRTEEHNVVILV 1202
            |||:|.|||:||.||.::.|||||||.:|||.||||...: ::|.         ..:|| :.||.
Mouse  1104 LNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGG---------HPQEH-LRILF 1158

  Fly  1203 EFAIALMSILDSINRES-FQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMG 1266
            |||..:|.::|..|... :..|:||:|.||||:.|||||..|..||||.:|||:|||||:.||..
Mouse  1159 EFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1223

  Fly  1267 RLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTY 1302
            |:|.:|.:.::|...||:.:.||...|||||.:.||
Mouse  1224 RIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	56/266 (21%)
		CYCc	259..467	CDD:214485	95/222 (43%)
		Guanylate_cyc	311..469	CDD:278633	84/157 (54%)
		BASP1	510..667	CDD:283191	40/178 (22%)
		CYCc	1079..1283	CDD:214485	91/205 (44%)
		Guanylate_cyc	1101..1305	CDD:278633	94/204 (46%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	25/141 (18%)
		Guanylate_cyc	385..573	CDD:306677	93/221 (42%)
		Guanylate_cyc	1069..1260	CDD:306677	94/203 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810