DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy8

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	1300	Identity:	397/1300 - (30%)
Similarity:	595/1300 - (45%)	Gaps:	357/1300 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRY--RQRLRKSLFRSGL--LTSLLACVV-------------SIIIGIVYGQHLVQTMLL 114
            |..||.||  .||.:..:..:.|  ||.|...|:             .|::|...|..:|...|:
Mouse   164 LERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALV 228

  Fly   115 VLAALISGSILTALQFPAVLSSPAAALAFAIVTT--FSLGTIAAITGDELAPLPMYALF--LCIH 175
            |:..  ..:..|.||:..|::       :..:||  .:.|....:.||.:.    |.||  ...:
Mouse   229 VVRK--DNTSHTYLQYSGVVT-------WVAMTTQILAAGLGYGLLGDGIG----YVLFTLFATY 280

  Fly   176 SMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPM-----LFGEIVMLASASVSGLYYRIMS 235
            ||||:....:::..|..:.:.:..::     ..|.|.:     :..::|:....:.:|::...:|
Mouse   281 SMLPLPLTWAILAGLGTSLLQVTLQV-----LIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLS 340

  Fly   236 DAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQAST 300
            |.|..:....||..:|.|::||.|.::||:|:|||:|.::..|:...:.....:..|.
Mouse   341 DRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQH------- 398

  Fly   301 SATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILG 365
               :||.:::.|:.||:|||||:..||.||::|:|.:||:.||:||.|||::|.|:.||||||||
Mouse   399 ---QFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILG 460

  Fly   366 DCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQF 430
            ||||||||||..|..||..||.|||.||..||.||..|..:||||||||:|:|||||||||||||
Mouse   461 DCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQF 525

  Fly   431 DVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKP 495
            ||||.||.:||.:||||:.||:||:|.|||.|...:.||:|.|..|:.:|..|.:|:|||..|:.
Mouse   526 DVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEE 590

  Fly   496 AYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSI 560
            :        :.|:                                      |..||.|.:|.:
Mouse   591 S--------LLCL--------------------------------------PEDIVKESVSCS-- 607

  Fly   561 NSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSA 625
                                      |..:.....||                      ||...
Mouse   608 --------------------------DRRNSGATFTE----------------------GSWSP- 623

  Fly   626 ASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAP 690
                       .||.|:::       |..|:.| |.:.|..::.|...|.|       |.|...|
Mouse   624 -----------ELPFDNIV-------GKQNTLA-ALTRNSINLLPNHLAQA-------LHVQSGP 662

  Fly   691 ERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGAD 755
            |...:::.                    ..:.:.||:..|..
Mouse   663 EEINKRIE--------------------HTIDLRSGDKLRRE----------------------- 684

  Fly   756 RPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQ 820
                                                        .:|||::.::::..|..|...
Mouse   685 --------------------------------------------HIKPFSLMFKDSSLEHKYSQM 705

  Fly   821 PDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGS--LLASFVSLALFLYLSNMSVPDVHASTT 883
            .|..|:.:|:|||::.|.:..:|        :||.|  |:...:..::.:.|.:..|
Mouse   706 RDEVFKSNLVCAFIVLLFITAIQ--------SLLPSSRLMPMTIQFSILIMLHSALV-------- 754

  Fly   884 ERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESN---FSSV 945
                  .:..:..|..|.:     ||..:|...                 |:|.|..|   |:|:
Mouse   755 ------LITTAEDYKCLPL-----ILRKTCCWI-----------------NETYLARNVIIFASI 791

  Fly   946 FVN--STLEDVQLW-EIDYAIPI-------APVFLYCCA----------ISLAAISAFLRSGFIL 990
            .:|  ..:.:: || :.|.:||:       :.||...|:          :::...:.|||...:|
Mouse   792 LINFLGAVLNI-LWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVL 855

  Fly   991 KLIAML--VAVIAQVTVLGYSDLFEMYNDANITHG----LPLEIKGFLLLLVIILVLHTLDRQGE 1049
            ||..:|  :|:.|.:|...|:.||..|:  |:.|.    |..:....||:.:.:|.:....:|.|
Mouse   856 KLAVLLIMIAIYALLTETIYAGLFLSYD--NLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLE 918

  Fly  1050 YVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLER-STELYHESYSCVAVMF 1113
            |.||.||||:.:.|.|..|::.:|..|:.:|.||||:|||.|||..:| :.|||.:||..|.|||
Mouse   919 YTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMF 983

  Fly  1114 ASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGK 1178
            ||||.:.:||.:|::|.||:||||||||||.|||:||.:.:|..|||||||.||||..|||.|.|
Mouse   984 ASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEK 1048

  Fly  1179 EDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQK 1243
            :.       .::|   ..::..|.:|::||...:..||:.||..|.||||::||.|:||||||:|
Mouse  1049 QQ-------CEDK---WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKK 1103

  Fly  1244 PQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKG----KGNLVTYFV 1304
            ||||||..|||:||||||.||.||:|..|.|..||...|:..:.||..||||    :|.:.|||:
Mouse  1104 PQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	57/247 (23%)
		CYCc	259..467	CDD:214485	113/207 (55%)
		Guanylate_cyc	311..469	CDD:278633	101/157 (64%)
		BASP1	510..667	CDD:283191	18/156 (12%)
		CYCc	1079..1283	CDD:214485	111/204 (54%)
		Guanylate_cyc	1101..1305	CDD:278633	109/207 (53%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180		7/15 (47%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118
		AC_N	<159..398	CDD:292831	57/251 (23%)
		CYCc	364..562	CDD:214485	113/207 (55%)
		Guanylate_cyc	403..587	CDD:278633	112/183 (61%)
		DUF1053	615..709	CDD:283888	28/229 (12%)
		CYCc	942..1146	CDD:214485	114/213 (54%)
		Guanylate_cyc	971..1170	CDD:278633	109/207 (53%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		32/61 (52%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710