DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy7

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	1309	Identity:	447/1309 - (34%)
Similarity:	627/1309 - (47%)	Gaps:	319/1309 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LYTRYR-QRLRKSLFRSGLLTSLLACVVSIIIG----------IVYG-QHLVQTMLLVLAALISG 122
            ||.:|| ..|...|....||.:...|:..|.|.          :|.| ..|:.|:.:.|..|:..
Mouse    21 LYEKYRLTSLHGPLLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYV 85

  Fly   123 SILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDEL---------APLPMYALFLCIHSML 178
            ..|......|:     |.|.:|.:..  ||::  :..|.|         .|..::.:|: ::::|
Mouse    86 ECLVQRWLRAL-----ALLTWACLMV--LGSV--LMWDSLENEAHAWEQVPFFLFVVFV-VYALL 140

  Fly   179 PISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLP------MLFGEIVMLASASVSGLYYR-IMSD 236
            |:|...::|..:..|..|::.....:..:..::.      .|....|:|...:.:|.::: .:.|
Mouse   141 PLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQD 205

  Fly   237 AAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTS 301
            |:.:..:...:. |:.|.||..|:.|||.|||||:||:|:..:|.:|:.::    :..|.:....
Mouse   206 ASRDLFIYTVKC-IQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERL----KEGGDRHYMP 265

  Fly   302 ATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGD 366
            ...||.|:|:||.||:||:||||.||.|:|..:..:||..||:|||:|||||:.|:|:|||||||
Mouse   266 DNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGD 330

  Fly   367 CYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFD 431
            |||||||||:|.|.||.|||.|||.:.:||:.||||||:::.||:|||:|||||||:||||||:|
Mouse   331 CYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYD 395

  Fly   432 VWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPA 496
            |||.||:|||.||:.||.||||||:.||:.|...:|||.|.|..||.||.:..:.:||::.|:
Mouse   396 VWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPR-- 458

  Fly   497 YTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
                        .|..|.|             ||.            ::.|..
Mouse   459 ------------SQQPPPP-------------SHH------------LSKPKG------------ 474

  Fly   562 SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAA 626
                  .|.|...||:.:....|....|                     .|.|:..||
Mouse   475 ------DATLKMRASVRVTRYLESWGAA---------------------RPFAHLNHR------- 505

  Fly   627 SESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPE 691
             |||                |.||:.|||...|            .|.|        |....||:
Mouse   506 -ESV----------------SSSETPISNGRRQ------------KAIP--------LRRHRAPD 533

  Fly   692 RSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADR 756
            ||                    |..:||                 ..:....:|...:|...:.|
Mouse   534 RS--------------------ASPKGR-----------------LEDDCDDEMLSAIEGLSSTR 561

  Fly   757 PFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQP 821
            |..:                           |..:|:.|||....|.|         |..||..|
Mouse   562 PCCS---------------------------KSDDFHTFGPIFLEKGF---------EREYRLVP 590

  Fly   822 DTHFRFDLICAFVLFLSLAVVQLIVIELNLALLG---SLLASFVSLAL-FLYLSNMSVPDVHAST 882
            ....|:|..||.::|:.:.:|.|:|:. .:|.||   .|:|..:.|.| |.:.:..|......||
Mouse   591 IPRARYDFACASLVFVCILLVHLLVMP-RMATLGVSFGLVACLLGLVLSFCFATEFSRCFPSRST 654

  Fly   883 TERNGPGQVVASSRYLR-LAMFVVVNILISSCAVFSVIN--YTVPDGVSKEPSSNQT--ILESNF 942
            .      |.::.|...: |...|:|.:.:.|....::||  .|:..| .::|..|:|  :...|
Mouse   655 L------QAISESVETQPLVRLVLVVLTVGSLLTVAIINMPLTLNPG-PEQPGDNKTSPLAAQN- 711

  Fly   943 SSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLG 1007
                           .:.....:.|.:...|.:...|.|.|||....||.:.:.||::|.:.:..
Mouse   712 ---------------RVGTPCELLPYYTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFN 761

  Fly  1008 YSDLFEMYNDANITHG------------------------------------LPLEIKGFLLLLV 1036
            .|..:.:..::..|:|                                    |.:.:..:|:|..
Mouse   762 LSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFY 826

  Fly  1037 IILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTEL 1101
            ..|:|  |.||.:|..|.|.|||.|.|.|.||.|||..:|::||||:||||||.||:..:.:.:.
Mouse   827 ATLIL--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDW 889

  Fly  1102 YHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIAS 1166
            ||:||.||.|||||:|::|.||.|.||||:||||||||||||.|||:|||||||||:||||||.|
Mouse   890 YHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGS 954

  Fly  1167 TYMCASGLR--PGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGL 1229
            |||.|:||.  .|.|:       .|.:|...| :.:||||::||||.||.|||.||..||||:|:
Mouse   955 TYMAAAGLSAPSGHEN-------QDLERKHVH-IGVLVEFSMALMSKLDGINRHSFNSFRLRVGI 1011

  Fly  1230 NHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVK 1294
            ||||||||||||:|||||||.|||||||||:|.|.:|::|.||.|..||...||.||||||..||
Mouse  1012 NHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVK 1076

  Fly  1295 GKGNLVTYF 1303
            |||.|.|||
Mouse  1077 GKGELRTYF 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/246 (24%)
		CYCc	259..467	CDD:214485	121/207 (58%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	26/156 (17%)
		CYCc	1079..1283	CDD:214485	131/205 (64%)
		Guanylate_cyc	1101..1305	CDD:278633	136/205 (66%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	42/186 (23%)
		Guanylate_cyc	272..422	CDD:306677	101/149 (68%)
		DUF1053	487..593	CDD:399378	41/243 (17%)
		Guanylate_cyc	890..1085	CDD:306677	134/202 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1757
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	729	1.000	Inparanoid score	I615
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46595
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830