Protein Alignment Ac76E and Adcy7

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1309
• Identity: 447/1309 - (34%)
• Similarity: 627/1309 - (47%)
• Gaps: 319/1309 - (24%)

  Fly    70 LYTRYR-QRLRKSLFRSGLLTSLLACVVSIIIG----------IVYG-QHLVQTMLLVLAALISG 122
            ||.:|| ..|...|....||.:...|:..|.|.          :|.| ..|:.|:.:.|..|:..
Mouse    21 LYEKYRLTSLHGPLLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYV 85

  Fly   123 SILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDEL---------APLPMYALFLCIHSML 178
            ..|......|:     |.|.:|.:..  ||::  :..|.|         .|..::.:|: ::::|
Mouse    86 ECLVQRWLRAL-----ALLTWACLMV--LGSV--LMWDSLENEAHAWEQVPFFLFVVFV-VYALL 140

  Fly   179 PISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLP------MLFGEIVMLASASVSGLYYR-IMSD 236
            |:|...::|..:..|..|::.....:..:..::.      .|....|:|...:.:|.::: .:.|
Mouse   141 PLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQD 205

  Fly   237 AAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTS 301
            |:.:..:...:. |:.|.||..|:.|||.|||||:||:|:..:|.:|:.::    :..|.:....
Mouse   206 ASRDLFIYTVKC-IQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERL----KEGGDRHYMP 265

  Fly   302 ATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGD 366
            ...||.|:|:||.||:||:||||.||.|:|..:..:||..||:|||:|||||:.|:|:|||||||
Mouse   266 DNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGD 330

  Fly   367 CYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFD 431
            |||||||||:|.|.||.|||.|||.:.:||:.||||||:::.||:|||:|||||||:||||||:|
Mouse   331 CYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYD 395

  Fly   432 VWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPA 496
            |||.||:|||.||:.||.||||||:.||:.|...:|||.|.|..||.||.:..:.:||::.|:
Mouse   396 VWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPR-- 458

  Fly   497 YTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
                        .|..|.|             ||.            ::.|..
Mouse   459 ------------SQQPPPP-------------SHH------------LSKPKG------------ 474

  Fly   562 SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAA 626
                  .|.|...||:.:....|....|                     .|.|:..||
Mouse   475 ------DATLKMRASVRVTRYLESWGAA---------------------RPFAHLNHR------- 505

  Fly   627 SESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPE 691
             |||                |.||:.|||...|            .|.|        |....||:
Mouse   506 -ESV----------------SSSETPISNGRRQ------------KAIP--------LRRHRAPD 533

  Fly   692 RSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADR 756
            ||                    |..:||                 ..:....:|...:|...:.|
Mouse   534 RS--------------------ASPKGR-----------------LEDDCDDEMLSAIEGLSSTR 561

  Fly   757 PFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQP 821
            |..:                           |..:|:.|||....|.|         |..||..|
Mouse   562 PCCS---------------------------KSDDFHTFGPIFLEKGF---------EREYRLVP 590

  Fly   822 DTHFRFDLICAFVLFLSLAVVQLIVIELNLALLG---SLLASFVSLAL-FLYLSNMSVPDVHAST 882
            ....|:|..||.::|:.:.:|.|:|:. .:|.||   .|:|..:.|.| |.:.:..|......||
Mouse   591 IPRARYDFACASLVFVCILLVHLLVMP-RMATLGVSFGLVACLLGLVLSFCFATEFSRCFPSRST 654

  Fly   883 TERNGPGQVVASSRYLR-LAMFVVVNILISSCAVFSVIN--YTVPDGVSKEPSSNQT--ILESNF 942
            .      |.::.|...: |...|:|.:.:.|....::||  .|:..| .::|..|:|  :...|
Mouse   655 L------QAISESVETQPLVRLVLVVLTVGSLLTVAIINMPLTLNPG-PEQPGDNKTSPLAAQN- 711

  Fly   943 SSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLG 1007
                           .:.....:.|.:...|.:...|.|.|||....||.:.:.||::|.:.:..
Mouse   712 ---------------RVGTPCELLPYYTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFN 761

  Fly  1008 YSDLFEMYNDANITHG------------------------------------LPLEIKGFLLLLV 1036
            .|..:.:..::..|:|                                    |.:.:..:|:|..
Mouse   762 LSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFY 826

  Fly  1037 IILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTEL 1101
            ..|:|  |.||.:|..|.|.|||.|.|.|.||.|||..:|::||||:||||||.||:..:.:.:.
Mouse   827 ATLIL--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDW 889

  Fly  1102 YHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIAS 1166
            ||:||.||.|||||:|::|.||.|.||||:||||||||||||.|||:|||||||||:||||||.|
Mouse   890 YHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGS 954

  Fly  1167 TYMCASGLR--PGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGL 1229
            |||.|:||.  .|.|:       .|.:|...| :.:||||::||||.||.|||.||..||||:|:
Mouse   955 TYMAAAGLSAPSGHEN-------QDLERKHVH-IGVLVEFSMALMSKLDGINRHSFNSFRLRVGI 1011

  Fly  1230 NHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVK 1294
            ||||||||||||:|||||||.|||||||||:|.|.:|::|.||.|..||...||.||||||..||
Mouse  1012 NHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVK 1076

  Fly  1295 GKGNLVTYF 1303
            |||.|.|||
Mouse  1077 GKGELRTYF 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	165/425 (39%)
		Guanylate_cyc	310..469	CDD:425528	104/158 (66%)
		Guanylate_cyc	1101..1305	CDD:425528	136/205 (66%)
Adcy7	XP_006530643.1	AcyC	48..456	CDD:441717	167/422 (40%)
		Guanylate_cyc	272..422	CDD:425528	101/149 (68%)
		Adcy_cons_dom	487..594	CDD:461877	41/244 (17%)
		Guanylate_cyc	890..1085	CDD:425528	134/202 (66%)